Lichens, natural unionsof fungi and green algae (and/or cyanobacteria) living in symbiosis, play significant roles in ecosystem function. In nature, lichens are well-known producers of natural products exhibiting a variety of biological activities, such as antibiotic, antiviral, antioxidant, anti-inflammatory and anticancer. However, the application of lichen natural products to pharmaceutical and agricultural industries has been limited, owing to lack of their mass production technology. To overcome this, we are analyzing genomic, transcriptomic andmetabolomic data derived from various lichen species forc ategorization and identification of genes responsible for the biosynthesis of lichen natural products. Our ultimate goal is toestablish a synthetic biology platform for gene cluster refactoring in order to produce a variety of lichen natural products.