국립순천대학교약학대학·약학과

학력

• 학 사 : 전북대학교 자연과학대학 화학과
• 석 사 : 전북대학교 자연과학대학 유기합성
• 박 사 : 서울대학교 자연과학대학 화학부 의약화학

주요경력

• 순천대학교 약학대학 약학과 교수(2020)
• 순천대학교 약학대학장(2017)
• (재)순천천연물의약소재개발센터장(2017)
• 순천대학교 약학대학 약학과 부교수(2015)
• 순천대학교 약학과장(2014)
• (재)순천천연물의약소재개발센터 사무국장(2013)
• 순천대학교 생명약학연구소장(2012)
• 순천대학교 약학대학 약학과 조교수(2011)
• 싱가포르 생명과학연구소 의약개발 선임연구원(2010)
• 싱가포르 화학과, Post-Doc(2009)
• JW Pharmaceutical 중앙연구소 신약개발팀장(2008)
• 미국 시애틀 화학유전체학 PNRI연구소 연구원(2004)
• 일본 로슈 분자의학연구소 연구원(1997)
• JW Pharmaceutical 중앙연구소 연구원(1995)

논문

• Assessing the photocatalytic activity of europium doped TiO2 using liquid phase plasma process on acetylsalicylic acid, Jung SC et al, Catalysis Today, 2020, in press
• The photocatalytic destruction of cimetidine using microwave-assisted TiO2 photocatalysts hybrid system, Park YK et al, J. Hazard Mater, 2020, 391, 122568
• Degradation behaviors of naproxen by a hybrid TiO2 photocatalyst system with process components, Jung SC et al, Sci Total Environ, 2020, 708, 135216
• Fabrication of Yb-doped TiO2 using liquid phase plasma process and its photocatalytic degradation activity of naproxen, Bang HJ et al, J. Mater Sci, 2020, 55(23), 1-11
• Assessment of Degradation Behavior for Acetylsalicylic Acid Using a Plasma in Liquid Process, Bang HJ et al, Catalysts, 2019, 9(11), 965
• A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2, Kim JJ et al, J. Am. Chem. Soc. 2019, 141(37), 14673?14686
• Differences in the Molecular Signatures of Mucosal-Associated Invariant T Cells and Conventional T Cells, Park D et al, Sci Rep., 2019, 9(1), 7094
• Physciosporin Suppresses the Proliferation, Motility and Tumourigenesis of Colorectal Cancer Cells, Isa Tas et al, Phytomedicine, 2019, 56, 10-20
• Antimicrobial Activity of Divaricatic Acid Isolated From the Lichen Evernia mesomorpha Against Methicillin-Resistant Staphylococcus aureus, Oh JM et al, molecules, 2018, 23(12), 3068
• Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer, Yi Yang et al, Sci Rep., 2018, 8(1), 16234
• Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Yi Yang et al, molecules, 2018, 23(11), 2968
• Mitochondria are physiologically maintained at close to 50 ˚C, Dominique Chr?tien et al, PLoS Biol, 2018, 16(1), e2003992
• Glycoprotein 90K Promotes E-Cadherin Degradation in a Cell Density-Dependent Manner via Dissociation of E-Cadherin-p120-Catenin Complex, Park SY et al, Int J Mol Sci, 2017, 18(12), 2601
• ENOblock, a unique small molecule inhibitor of h4e non-glycolytic functions of enolase, alleviates h4e symptoms of type 2 diabetes, Haaglim Cho et al. Scientific Reports, 2017, 7:44186
• Development of background-free tame fluorescent probes for intracellular live cell imaging, Samira Husen Alamudi et al. NATURE COMMUNICATIONS, 2016
• Inhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility, Yi Yang et al. PLOS one, 2016, 11(1):e0146575
• Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility, Yi Yang et al , PLOS one, 2015
• Mitochondria-targeted fluorescent h4ermometer monitors intracellular temperature gradient, Satoshi Arai et al , Chem. Commun. 2015, 51, 8044-8047.
• Diversity-Oriented Approach for Chemical Biology, Jun-Seok Lee et al, The Chemical Record. 2015, 15, 495-510
• Chemical Targeting of GAPDH Moonlighting Function in Cancer Cells Reveals Its Role in Tubulin Regulation, Da-Woon Jung et al , Chemistry & Biology. 2014, 21, 1533-1545,
• Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development, Yun, S. W. et al , Acc. Chem. Res. 2014, 47, 1277-1286.
• Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene ex-pression analyses, Park, S. J. et al , Stem Cell Res. 2014, 12, 730-741.
• A fluorescent probe for imaging symmetric and asymmetric cell division in neurospher formation, Yun, S. W. et al , Chem. Commun. 2014, 50, 7492-7494.
• Inhibition of tau aggregation by a rosamine derivative h4at blocks tau intermolecular disulfide cross-linking, Haque, M. M. et al , Amyloid 2014, 21, 185-190.
• Visualization and isolation of Langerhans islets by fluorescent probe PiY, Kang, N. Y. et al , Angew. Chem., Int. Ed. Engl. 2013, 52, 8557-8560
• A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes, Jung, D. W. et al , ACS Chem. Biol. 2013, 8, 1271-1282.
• Combinatorial solid-phase synh4esis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and h4eir application to efficient biofuel production, Kim, J. Y. et al , ACS Comb. Sci. 2012, 14, 395-398.
• A fluorescent screening platform for h4e rapid evaluation of chemicals in cellular reprogramming, Vendrell, M. et al , Stem Cell Res. 2012, 9, 185-191.
• Solid phase combinatorial synh4esis of a xanh4one library using click chemistry and its application to an embryonic stem cell probe, Ghosh, K. K.; Hyung-Ho Ha.; Kang, N. Y.; Chandran, Y.; Chang, Y. T. Chem. Commun. 2011, 47, 7488-7490.
• Embryonic and induced pluripotent stem cell staining and sorting using live cell fluorescence imaging probe CDy1, Kang, N. Y.; Yun, S. W.; Hyung-Ho Ha.; Park, S. J.; Chang, Y. T. Nat. Protoc. 2011, 6, 1044-1052.
• Diversity-driven chemical probe development for biomolecules: beyond hypoh4esis-driven approach, Kang, N. Y.; Hyung-Ho Ha.; Yun, S. W.; Yu, Y. H.; Chang, Y. T. Chem. Soc. Rev. 2011, 40, 3613-3626.
• Fluorescent labeling of membrane proteins on h4e surface of living cells by a self-catalytic glutah4ione S-transferase omega 1 tag, Lee, J. J.; Son, J.; Hyung-Ho Ha.; Chang, Y. T. Mol. Biosyst. 2011, 7, 1270-1276.
• The binding of fluorophores to proteins depends on h4e cellular environment, Kim, Y. K.; Lee, J. S.; Bi, X.; Hyung-Ho Ha; Ng, S. H.; Ahn, Y. H.; Lee, J. J.; Wagner, B. K.; Clemons, P. A.; Chang, Y. T. Angew. Chem., Int. Ed. Engl. 2011, 50, 2761-2763.
• Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects, Jung, D. W.; Hyung-Ho Ha.; Zheng, X.; Chang, Y. T.; Williams, D. R. Mol. Biosyst. 2011, 7, 346-358.
• A fluorescent rosamine compound selectively stains pluripotent stem cells, Im, C. N.; Kang, N. Y.; Hyung-Ho Ha.; Bi, X.; Lee, J. J.; Park, S. J.; Lee, S. Y.; Vendrell, M.; Kim, Y. K.; Lee, J. S.; Li, J.; Ahn, Y. H.; Feng, B.; Ng, H. H.; Yun, S. W.; Chang, Y. T. Angew. Chem., Int. Ed. Engl., 2010, 49, 7497-7500. (pdf) (SI) Highlighted at "Fluorescence meh4od detects stem cells, C&En News 2010, 88(38), p25"
• Control of Muscle Differentiation by a Mitochondria-Targeted Fluorophore. Yun Kyung Kim, Hyung-Ho Ha, Jun-Seok Lee, Xuezhi Bi, Young-Hoon Ahn, Siti Hajar, Jae-Jung Lee and Young-Tae Chang. J. Am. Chem. Soc. 2010, 132, 576.
• Discovery of Novel Zebrafish Neural Tracers by Organism-based Screening of Rosamine Library. Jun Li, Hyung-Ho Ha, Lin Guo, David Coomber, and Young-Tae Chang. Chem. Commun. 2010, 46, 2932-2934.
• Novel Heterocycle-substituted Pyrimidines as Inhibitors of NF-kB Transcription Regulation Related to TNF-a Cytokine Release. Hyung-Ho Ha, Jee Seon Kim and B. Moon Kim, Bioorg. Med. Chem. Lett. 2008, 18.653

학력

• 학 사 : 부산대학교
• 석 사 : 부산대학교
• 박 사 : 미국 오레곤 주립대학

주요경력

• 한국소비자원 위해정보평가위원회 위원
• 제6대 순천대학교 약학대학장
• 순천대학교 약학대학 교수
• 한국의약품안전관리원 의약품부작용위원회 위원
• 순천대학교 학생부처장
• 농촌진흥청 농약안전성심의위원회 위원
• 건강보험심사평가원 진료심사평가위원회 비상근심사위원
• 순천대학교 약학대학 부교수
• 순천대학교 약학대학 조교수
• 식품의약품안전청 의약품심사부 소화계약품과 심사관
• 영남대학교 의과대학 연구교수
• 미국 컴언웰스대학교 의과대학 Post-Doc.
• 미국 오레곤건강과학대학교 독성학센터 Post-Doc.

논문

• Nguyen HD, Kim MS. Roles of Curcumin on Cognitive Impairment Induced by a Mixture of Heavy Metals. Neurotox Res. 2022 Oct 5. doi: 10.1007/s12640-022-00583-7. Online ahead of print.
• Nguyen HD, Kim MS. The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships : The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships. Biol Trace Elem Res. 2022 Jul 7. doi: 10.1007/s12011-022-03343-y. Online ahead of print.
• Nguyen HD, Jo WH, Hoang NHM, Kim MS. Curcumin-Attenuated TREM-1/DAP12/NLRP3/Caspase-1/IL1B, TLR4/NF-κB Pathways, and Tau Hyperphosphorylation Induced by 1,2-Diacetyl Benzene: An in Vitro and in Silico Study. Neurotox Res. 2022 Oct;40(5):1272-1291.
• Nguyen HD, Kim MS. Effects of heavy metals on cardiovascular diseases in pre and post-menopausal women: from big data to molecular mechanism involved.Environ Sci Pollut Res Int. 2022  Nov;29(51):77635-77655.
• Nguyen HD, Jo WH, Hoang NHM, Kim MS. In silico identification of the potential molecular mechanisms involved in protective effects of prolactin on motor and memory deficits induced by 1,2-Diacetylbenzene in young and old rats. Neurotoxicology. 2022 Dec;93:45-59.
• Nguyen HD, Oh H, Kim MS. The effects of chemical mixtures on lipid profiles in the Korean adult population: threshold and molecular mechanisms for dyslipidemia involved. Environ Sci Pollut Res Int. 2022 Jun;29(26):39182-39208.
  
• Nguyen HD, Kim MS. The protective effects of curcumin on depression: Genes, transcription factors, and microRNAs involved. J Affect Disord. 2022 Dec 15;319:526-537.
• Duc Nguyen H, Hoang NMH, Jo WH, Ham JR, Lee MK, Kim MS. Associations among the TREM-1 Pathway, Tau Hyperphosphorylation, Prolactin ex-pression, and Metformin in Diabetes Mice. Neuroimmunomodulation. 2022 Feb 7:1-10.
• Nguyen HD, Oh H, Kim MS. Higher intakes of fruits, vegetables, and multiple individual nutrients is associated with a lower risk of metabolic syndrome among adults with comorbidities. Nutr Res. 2022 Mar;99:1-12.
• Nguyen HD, Kim MS. Effects of chemical mixtures on liver function biomarkers in the Korean adult population: thresholds and molecular mechanisms for non-alcoholic fatty liver disease involved. Environ Sci Pollut Res Int. 2022 Nov;29(52):78555-78587.
• Nguyen HD, Kim MS. Exposure to a mixture of heavy metals induces cognitive impairment: Genes and microRNAs involved. Toxicology. 2022 Mar 25;471:153164.
• Yun S, Nguyen HD, Park JS, Oh C, Kim MS. The association between the metabolic syndrome and iron status in pre- and postmenopausal women: Korean National Health and Nutrition Examination Survey (KNHANES) in 2012. Br J Nutr. (2022). 127(4):630-640.
• Nguyen HD, Kim MS. The role of mixed B vitamin intakes on cognitive performance: Modeling, genes and miRNAs involved. J Psychiatr Res. 2022 Aug;152:38-56.
• Duc Nguyen H, Oh H, Yu BP, Hoang NMH, Jo WH, Young Chung H, Kim MS. Associations between Prolactin, Diabetes, and Cognitive Impairment: A Literature Review. Neuroendocrinology.  2022;112(9):856-873.
• Duc Nguyen H, Pal Yu B, Hoang NHM, Jo WH, Young Chung H, Kim MS. Prolactin and Its Altered Action in Alzheimer's Disease and Parkinson's Disease  Neuroendocrinology. 2022;112(5):427-445.
• Nguyen HD, Kim MS. Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases. Environ Pollut. 2022 Sep 15;309:119780.
• Nguyen HD, Oh H, Kim MS. Mixtures modeling identifies vitamin B1 and B3 intakes associated with depression. J Affect Disord. 2022 Mar 15;301:68-80.
• Nguyen HD, Oh H, Jo WH, Hoang NHM, Kim MS. Mixtures modeling identifies heavy metals and pyrethroid insecticide metabolites associated with obesity. Environ Sci Pollut Res Int. 2022 Mar;29(14):20379-20397.
• Duc HN, Oh H, Kim MS. The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50 Years of Age.Biol Trace Elem Res. 2022 Aug;200(8):3554-3571.
• Duc Nguyen H, Hoang NMH, Ko M, Seo D, Kim S, Jo WH, Bae JW, Kim MS. Association between Serum Prolactin Levels and Neurodegenerative Diseases: Systematic Review and Meta-Analysis.Neuroimmunomodulation. 2022;29(2):85-96.
• Nguyen HD, Oh H,Kim MS. An increased intake of nutrients, fruits, and green vegetables was negatively related to the risk of arthritis and osteoarthritis development in the aging population.Nutr Res. 2022 Mar;99:51-65.
• Nguyen HD, Oh H, Hoang NHM, Jo WH, Kim MS. Environmental science and pollution research role of heavy metal concentrations and vitamin intake from food in depression: anationalcross-sectional study (2009-2017). Environ Sci Pollut Res Int. 2022 Jan;29(3):4574-4586.
• Nguyen HD, Kim MS. The protective effects of curcumin on metabolic syndrome and its components: In-silico analysis for genes, transcription factors, and microRNAs involved. Arch Biochem Biophys. 2022 Sep 30;727:109326.
• Nguyen HD, Oh H, Kim MS. Higher intakes of nutrients are linked with a lower risk of cardiovascular diseases, type 2 diabetes mellitus, arthritis, and depression among Korean adults. Nutr Res. 2022 Apr;100:19-32.
• Nguyen HD, Oh H, Kim MS. An increased intake of thiamine diminishes the risk of metabolic syndrome in the Korean population with various comorbidities. Diabetes Metab Syndr. 2022 Mar;16(3):102443.
• Nguyen HD, Oh H, Kim MS. The association between curry-rice consumption and hypertension, type 2 diabetes, and depression: The findings from KNHANES 2012-2016. Diabetes Metab Syndr. 2022 Jan;16(1):102378
• Duc Nguyen H, Hee Jo W, Hong Minh Hoang N, Kim MS. Anti-inflammatory effects of B vitamins protect against tau hyperphosphorylation and cognitive impairment induced by 1,2 diacetyl benzene: An in vitro and in silico study.Int Immunopharmacol. 2022 Jul;108:108736.
• Duc Nguyen H, Oh H, Kim MS. Association between exposure to chemical mixtures in relation to serum total IgE among adults 19-86 years old. Int Immunopharmacol. 2022 Jan;102:108428
• Nguyen HD, Jo WH, Hoang NHM, Yu BP, Chung HY, Kim MS. 1,2-Diacetylbenzene impaired hippocampal memory by activating proinflammatory cytokines and upregulating the prolactin pathway: An in vivo and in vitro study. Int Immunopharmacol. 2022 Jul;108:108901.
• Nguyen HD, Jo WH, Hoang NHM, Yu BP, Chung HY, Kim MS. Corrigendum to "1,2-diacetylbenzene impaired hippocampal memory by activating proinflammatory cytokines and upregulating the prolactin pathway: An in vivo and in vitro study" [Int. Immunopharmacol. 108 (2022) 108901]. Int Immunopharmacol. 2022 Oct;111:109156.
• Nguyen HD, Oh H, Kim MS. Action plans for depression management in South Korea: Evidence-based on depression survey data in 2009-2019 and during the COVID-19 pandemic. Health Policy Technol. 2021 Dec;10(4):100575.
• Nguyen HD, Oh H, Hoang NHM, Kim MS. Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population.Sci Rep. 2021 Jul 19;11(1):14664.
• Oh H, Nguyen HD, Yoon IM, Ahn BR, Kim MS. Antidiabetic effect of gemigliptin: a systematic review and meta-analysis of randomized controlled trials with Bayesian inference through a quality management system. Sci Rep. 2021 Oct 22;11(1):20938.
• Nguyen HD, Kim MS. Effects of heavy metal, vitamin, and curry consumption on metabolic syndrome during menopause: a Korean community-based cross-sectional study.  Menopause. 2021 Jul 19;28(8):949-959.
• Hoang NMH, Kim S, Nguyen HD, Kim M, Kim J, Kim BC, Park D, Lee S, Yu BP, Chung HY, Kim MS. Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene. Biomol Ther (Seoul). (2021). 1;29(4):399-409.
• Nguyen HD, Oh H, Kim MS. Effects of heavy metals on hypertension during menopause: a Korean community-based cross-sectional study. Menopause. (2021). 28(12):1400-1409.
• Oh H, Nguyen HD, Yoon IM, Kim MS. Efficacy and Tolerability of Evogliptin in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis with Bayesian Inference Through a Quality-management System. Clin Ther. (2021). ;43(8):1336-1355.
• Duc HN, Oh H, Kim MS. Effects of Antioxidant Vitamins, Curry Consumption, and Heavy Metal Levels on Metabolic Syndrome with Comorbidities: A Korean Community-Based Cross-Sectional Study. Antioxidants (Basel). 2021 May 19;10(5):808.
• Duc HN, Oh H, Yoon IM, Kim MS. Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: anationalcross-sectional study.  J Nutr Sci. 2021 Apr 27;10:e31. doi: 10.1017/jns.2021.23. eCollection 2021.
• 권무길, 박신혜, 김민선. 농축 누에 번데기 오일의 주름개선 효과. 한국미용학회지,  (2019). 제25권, 제6호 p1-7.
• 강병훈, 김민선, 박영철. 임신마우스에 기도 점적투여를 통한 가습기살균제 CMIT/MIT의 사산에 대한 영향. 한국환경보건학회지. 2018. 10; 44(5):468-479.
• M. Kim, K-S, Seo, K.W. Yun. Antimicrobial and Antioxidant Activity of Saposhnikovia divaricata, Peucedanum japonicum, and Glehnia littoralis. Indian Journal of Pharmaceutical Sciences. 2018. May-June; 80(3): 560-565.
• Choi JW, Oh C, Shim SY, Jeong S, Kim HS, Kim MS. Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean. Tohoku J Exp Med. 2018 Mar;244(3):219-229.
• Lee Y, Kim MS, Lee J. Neuroprotective strategies to prevent and treat Parkinson's disease based on its pathophysiological mechanism. Arch Pharm Res. 2017 Oct;40(10):1117-1128.
• Kang SW, Kim SJ, Kim MS. Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice. Toxicol Lett. 2017 Sep 5;279:53-59.
• Lee B, Moon KM, Kim SJ, Kim SH, Kim DH, An HJ, Jeong JW, Kim YR, Son S, Kim MJ, Chung KW, Lee EK, Chun P, Ha YM, Kim MS, Mo SH, Moon HR, Chung HY. (Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice. Oxid Med Cell Longev. 2016;2016:2761463.
• Yoo HD, Nam SJ, Chin YW, Kim MS. Misassigned natural products and their revised structures. Arch Pharm Res. Arch Pharm Res. 2016 Feb;39(2):143-53
• Sung B, Park S, Ha YM, Kim DH, Park CH, Jung KJ, Kim MS, Kim YJ, Kim MK, Moon JO, Yokozawa T, Kim ND, Yu BP, Chung HY. Salicylideneamino-2-thiophenol modulates nuclear factor-κB through redox regulation during the aging process. (2015) Geriatr Gerontol Int. 15(2):211-9
• Kim H¹, Yang I, Patil RS, Kang S, Lee J, Choi H, Kim MS, Nam SJ, Kang H.  Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp. (2014)  J Nat Prod. 77(12):2716-9
• Nugroho A, Rhim TJ, Choi MY, Choi JS, Kim YC, Kim MS, Park HJ. Simultaneous analysis and peroxynitrite-scavenging activity of galloylated flavonoid glycosides and ellagic acid in Euphorbia supina. (2014). Arch Pharm Res. 37(7):890-8.
• Jung HA¹, Jung HJ, Jeong HY, Kwon HJ, Kim MS, Choi JS. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes (2014) Arch Pharm Res. 37(6):713-20.
• Ji ST, Kim MS, Park HR, Lee E, Lee Y, Jang YJ, Kim HS, Lee J. Diallyl disulfide impairs hippocampal neurogenesis in the young adult brain. (2013). Toxicol Lett. 221(1):31-8.
• Kim DH, Chung JH, Yoon JS, Ha YM, Bae S, Lee EK, Jung KJ, Kim MS, Kim YJ, Kim MK, Chung HY. (2013). Ginsenoside Rd inhibits the ex-pressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver. J Ginseng Res. 37(1):54-63.
• Lee Y, Oh SB, Park HR, Kim HS, Kim MS, Lee J. Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption. (2013). Neurosci Lett. 535:134-9.
• Kim HJ, Lee EK, Park MH, Ha YM, Jung KJ, Kim MS, Kim MK, Yu BP, Chung HY. Ferulate protects the epithelial barrier by maintaining tight junction protein ex-pression and preventing apoptosis in tert-butyl hydroperoxide-induced Caco-2 cells. (2013). Phytother Res. 27(3):362-7
• Kim MS, Park HR, Chung HY, Kim HS, Yu BP, Yang HS, Lee J. Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Chem Biol Interact. 2011;194(2-3):139-47.
• Kong KH, Kim HK, Song KS, Woo YS, Choi WS, Park HR, Park M, Kim ME, Kim MS, Ryu JS, Kim HS, Lee J. Capsaicin impairs proliferation of neural progenitor cells and hippocampal neurogenesis in young mice. J Toxicol Environ Health A. 2010;73(21-22):1490-501.
• Park HR, Kim MS, Kim SJ, Park M, Kong KH, Kim HS, Kwack SJ, Kang TS, Kim SH, Kim HS, Lee J. Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis. Toxicol Lett. 1;193(1):86-93. 2010 .
• Hong SE, Heo HS, Kim DH, Kim MS, Kim CH, Lee J, Yoo MA, Yu BP, Leeuwenburgh C, Chung HY. Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome. Age (Dordr).;32(1):15-30.  2010 .
• Park M, Park HR, Kim SJ, Kim MS, Kong KH, Kim HS, Gong EJ, Kim ME, Kim HS, Lee BM, Lee J. Risk assessment for the combinational effects of food color additives: neural progenitor cells and hippocampal neurogenesis. J Toxicol Environ Health A. 72(21-22):1412-23. 2009.
• Kim TH, Lee YJ, Lee E, Kim MS, Kwack SJ, Kim KB, Chung KK, Kang TS, Han SY, Lee J, Lee BM, Kim HS. Effects of gestational exposure to decabromodiphenyl ether on reproductive parameters, thyroid hormone levels, and neuronal development in Sprague-Dawley rats offspring. J Toxicol Environ Health A. 72(21-22):1296-303. 2009. 
• Park MJ, Lee EK, Heo HS, Kim MS, Sung B, Kim MK, Lee J, Kim ND, Anton S, Choi JS, Yu BP, Chung HY. The anti-inflammatory effect of kaempferol in aged kidney tissues: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinase pathways. J Med Food. 12(2):351-8. 2009
• Son TG, Park HR, Kim SJ, Kim K, Kim MS, Ishigami A, Handa S, Maruyama N, Chung HY, Lee J. Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis. J Neurosci Res. 87(13):2890-7. 2009.
• Kim MS, Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, Kim SH, Lee J. Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. Toxicology. 16;260(1-3):97-103. 2009.
• Son TG, Kim SJ, Kim K, Kim MS, Chung HY, Lee J. Cytoprotective roles of senescence marker protein 30 against intracellular calcium elevation and oxidative stress. Arch Pharm Res 31:872-7. 2008
• Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol Chem. 283:14497-505. 2008
• Kim MS, Kim MK, Kim KS, Chung JH, Kim SJ, Kim JH, Kim JR, Lee J, Yu BP, Chung HY. Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress.Toxicology 243:216-23, 2008.
• Kim, K. S., Kim, M. S., Seu, Y. B., Chung, H.Y., Kim, J.H., Kim, J.R.  Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells. Aging Cell. 6:535-45, 2007.
• Kim MK, Kim KS, Chung JH, Kim JH, Kim JR, Chung HY, Kim MS. Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells.  J Toxicol Environ Health A 70:1336-43, 2007
• Kim DH, Kim CH, Kim MS, Kim JY, Jung KJ, Chung JH, An WG, Lee JW, Yu BP, Chung HY. Suppression of age-related inflammatory NF-kB activation by cinnamaldehyde. Biogerontology  8: 545-554, 2007
• Zou Y, Yoon S, Jung KJ, Kim CH, Son TG, Kim MS, Kim YJ, Lee J, Yu BP, Chung HY. Upregulation of aortic adhesion molecules during aging.  J Gerontol A Biol Sci Med Sci. 61: 232-244, 2006
• No, JK, Kim MS, Kim YJ, Bae SJ, Choi JS, Chung HY. Inhibition of tyrosinase by protocatechuic aldehyde. Am J Chin Med. 32, 97-103, 2004.
• Kim AR, Zou YN, Park TH, Shim KH, Kim MS, Kim ND, Kim JD, Bae SJ, Choi JS, Chung HY. Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity. Phytother Res. 18, 1-7. 2004.
• Soung DY, Choi HR, Kim JY, No JK, Lee JH, Kim MS, Rhee SH, Park JS, Kim MJ, Yang R, Chung HY. Peroxynitrite scavenging activity of indole derivatives: interaction of indoles with peroxynitrite. J Med Food. Spring;7(1):84-9. 2004.
• Kim, M-S., Hashemi, S.B., Spencer, P.S., and Sabri, M.I. Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. Toxicol. Appl. Pharmacol. 183, 55-65. 2002.
• Spencer, P.S., Kim, M.S., and Sabri, M.I. Aromatic as well as aliphatic hydrocarbon solvent axonopathy. Int. J. Hyg. Environ. Health 20, 131-136. 2002.
• Zhan, C-G, Dixon, D.A, Kim, M-S., Sabri, M.I., and Spencer, P.S. Theoretical   determination of chromophores in the chromogenic effects of aromatic neurotoxicants. J. Am. Chem. Soc. 124(11), 2744-2752. 2002.
• Kim, M-S., Sabri, M.I., Miller, V., Kayton, R., and Spencer, P.S. 1,2-Diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic organic solvent, induces proximal axonopathy. Toxicol. Appl. Pharmacol. 177, 121-131. 2001.
• Kim, M.S., Kayton, R., Mu?iz, J., Austin, D.R., Spencer, P.S. and Sabri, M.I. 1,2-Diacetylbenzene neurotoxicity:  A model to study the role of Schwann cells in maintenance of axonal integrity in toxic states.  Microsc. Microanal. 5 (Suppl. 2),  1218-1219. 1999.
• Kim, M.S., Park, H.J., and Choi, J.S. Study on the constituent of Catalpa ovata -isolation of 6’-feruloyl sucrose. Pusan Bull. Pharm. Sci. 26, 14-18. 1992.
• Young, H.S., Kim, M.S., Park, H.J., Chung, H.Y., and Choi, J.S. Phytochemical study on Catalpa ovata. Arch. Pharm. Res. 15, 322-327. 1992.
• Young, H.S., Kim, M.S., Chung, H.Y., Choi, J.S., and Kim, B.W. Separation of active chemical components against sarcoma 180 from stembark of Catalpa ovata. J. Rep. Korean Cancer Assoc., 24, 807-812. 1992.
• Bae, J.M., Kim, M.S., Park, H.J., Young, H.S., Park, K.Y., Moon, S.H., and Choi, J.S. Antimutagenic principle of Artemisia imayomogi kit. and its action mechanism. J. Rep. Korean Cancer Assoc., 24, 73-76. 1992.
• Kim, M.S., Bae, J.M., Park, H.J., Chung, H.Y., Choi, J.S., and Park, G.Y. Separation of antimutagenic substance from stembark of Catalpa ovata. Environ. Mutag. Carcinog. 12, 147-155. 1992.

학력

• 학 사 : 전남대학교 약학대학 약학과
• 석 사 : 전남대학교 약학대학(병태생리학)
• 박 사 : 전남대학교 약학대학(병태생리학)

주요경력

• Guest Editor of SI on IJMS #1-1, #1-2, #1-3, #2
• EBM of Scientific Reports, Oncology Letters, International Journal of Molecular Sciences (IJMS)
• 한국연구재단 국책연구본부 전문위원
• 식품의약품안전처 건강기능식품심의위원회 위원
• 약학회지 편집간사
• 대한약학회 학술간사/학술부위원장/홍보위원장
• 미국암학회(AACR) 정회원
• 한국분자세포생물학회 뉴스지편집위원
• 대한약리학회 학술위원/대외협력위원/재무부위원장
• 한국독성학회/한국환경성돌연변이발암원학회 전남지부장
• 순천대학교 교수회 제20기 교수평의회 평의원
• 순천대학교 생명약학연구소장
• (재)순천천연물의약소재개발연구센터 사무국장
• 순천대학교 약학대학 약학과 전임강사, 조교수, 부교수, 교수(2011-현재)
• 전남대학교 의과대학 약리학교실 박사후연구원(2010-2011)

논문

• 논문 바로가기

학력

• 학 사 : 서울대학교
• 석 사 : 서울대학교
• 박 사 : University of Michigan, Ann Arbor (2007)

주요경력

• LG화학 기술연구원 바이오텍연구소 연구원
• University of Michigan, Ann Arbor 박사 후 연구원
• NAL Pharmaceuticals, Manager, Technology Development

논문

• P. Maharjan, K.H. Cho, A. Maharjan, M.C. Shin, C. Moon, and K.A. Min. “Pharmaceutical challenges and perspectives in developing ophthalmic drug formulations.” J. Pharm. Investigation. 49: 215-228, 2019
• E. Oh, U. Kim, B.J. Lee, and C. Moon. “Multivariate Statistical Optimization of Tablet Formulations Incorporating High Doses of a Dry Herbal Extract.” Pharmaceutics, 11: 79. 2019
• T. Park, K.A. Min, H. Cheong, C. Moon, and M.C. Shin. “Genetic engineering and characterisation of chlorotoxin-fused gelonin for enhanced glioblastoma therapy.” J Drug Targeting, e-Published. 2018
• H. Song, C. Moon, B.J. Lee, and E. Oh. “Mesoporous Pravastatin Solid Dispersion Granules Incorporable Into Orally Disintegrating Tablets.” J Pharm Sci. 107: 1886-1895, 2018
• T. V. Nguyen, M. C. Shin, K. A. Min, Y. Huang. E. Oh and C. Moon. “Cell-penetrating peptide-based non-invasive topical delivery systems.” J. Pharm. Investigation. 48: 77-87, 2018
• H. Wang, C. Moon, M.C.Shin,, Y. Wang, H. He, V.C. Yang, and Y. Huang. “Heparin-regulated prodrug-type macromolecular theranostic systems for cancer therapy.” Nanotheranostics. 1: 114-130, 2017
• M. C. Shin, K. A. Min, H. Cheong, C. Moon, Y. Huang, H. He, and V. C. Yang. “Tandem-multimeric F3-gelonin fusion toxins for enhanced anti-cancer activity for prostate cancer treatment.” Int J Pharm. 524: 101-110, 2017
• C. Moon and E. Oh. "Rationale and strategies for formulation development of oral fixed dose combination drug products." J. Pharm. Investigation. 46: 615-631, 2016
• S. Kim, B. Gupta, C. Moon, E. Oh, J. Jeong, C. S. Yong, and J. O. Kim. "Employing an optimized spray-drying process to produce ezetimibe tablets with an improved dissolution profile” J. Pharm. Investigation. 46: 583-592, 2016
• T. Lin, E. Liu, H. He, M. C. Shin, C. Moon, V. C. Yang, and Y. Huang. “Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides”. Acta Pharm. Sin. B. 6: 352-358, 2016
• M. C. Shin, K. A. Min, H. Cheong, C. Moon, Y. Huang, H. He, and V. C. Yang. “Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity” Pharm. Res. 33: 2218-2228, 2016
• D. J. Jang, C. Moon, E. Oh, Improved tumor targeting and antitumor activity of camptothecin loaded solid lipid nanoparticles by preinjection of blank solid lipid nanoparticles. Biomed Pharmacother. 80:162-172, 2016
• D. H. Truong, T. H. Tran, T. Ramasamy, J. Y. Choi, H. H. Lee, C. Moon, H. G. Choi, C. S. Yong, and J. O. Kim. “Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib.” AAPS PharmSciTech 17: 466-473, 2016
• Y. Yang, S. Y. Park, T. T. Nguyen, Y. H. Yu, T. V. Nguyen, E. G. Sun, J. Udeni, M. H. Jeong, I. Pereira, C. Moon, H. H. Ha, K. K. Kim, J. S. Hur, H. Kim, “Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility.” PLoS One. 10: e0137889, 2015
• J. Tan, H. Cheong, Y. S. Park, H. Kim, M. Zhang, C. Moon*, and Y. Huang*. “Cell-penetrating peptide-mediated topical delivery of biomacromolecular drugs.” Curr Pharm Biotechnol. 15:231-239, 2014
• M. C. Shin, J. Zhang, K. A. Min, K. Lee, C. Moon, J. P Balthasar, and V. C. Yang. “Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy.” J Control Release. 194:197-210, 2014
• T. T. Nguyen, S. Yoon, Y. Yang, H. B. Lee, S. Oh, M. H. Jeong, J. J. Kim, S. T. Yee, F. Cri?an, C. Moon, K. Y. Lee, K. K. Kim, J. S. Hur, and H. Kim, “Lichen secondary metabolites in Flavocetraria cucullata exhibit anti-cancer effects on human cancer cells through the induction of apoptosis and suppression of tumorigenic potentials.” PLoS One. 9: e111575, 2014
• K. H. Kim, S. A. Cho, J. Y. Lim, C. Moon, and S. H. Jeong “Preparation of microcapsules with the evaluation of physicochemical properties and molecular interaction” Arch. Pharm. Res. 37: 1570-1577, 2014
• D. H. Truong, T. H. Tran, T. Ramasamy, J. Y. Choi, H. H. Lee, C. Moon, H. G. Choi, C. S. Yong, and J. O. Kim. "Development of Solid Self-Emulsifying Formulation for Improving h4e Oral Bioavailability of Erlotinib." AAPS PharmSciTech. E-published (2015-8-4)
• J. Tan, H. Cheong, Y. S. Park, H. Kim, M. Zhang, C. Moon, and Y. Huang. "Cell-penetrating peptide-mediated topical delivery of biomacromolecular drugs." Curr Pharm Biotechnol. 15:231-239, 2014
• M. C. Shin, J. Zhang,,K. A. Min, K. Lee, C. Moon, J. P Balh4asar, and V. C. Yang. "Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer h4erapy." J Control Release. 194:197-210, 2014
• K. H. Kim, S. A. Cho, J. Y. Lim, C. Moon, and S. H. Jeong "Preparation of microcapsules wih4 h4e evaluation of physicochemical properties and molecular interaction" Arch. Pharm. Res. 37: 1570-1577, 2014
• A. E. David, J. Gong, B. Chertok, R.C. Domszy, C. Moon, Y. S. Park, N. S. Wang, A. J. Yang, and V. C. Yang, "Immobilized h4ermolysin for highly efficient production of low molecular weight protamine - an attractive cell - penetrating peptide for macromolecular drug delivery applications. "J. Biomed. Mater. Res. A. 100A: 211-219, 2012
• R. K. Subedi, J. P. Ryoo, C. Moon, and H. K. Choi, "Influence of formulation variables in transdermal drug delivery system containing zolmitriptan" Int. J. Pharm. 419:209-214, 2011
• Y. Huang, Y. S. Park, C. Moon, A. E. David, H. S. Chung, and V. C. Yang, "Synh4etic skin-permeable antigens enabling transcutaneous immunization" Angew. Chem. Int. Ed. 49:2724-2727, 2010
• Y. M. Kwon, H. S. Chung, C. Moon, J. Yockman, Y. J. Park, S. D. Gitlin, A. E. David, and V. C. Yang, "L-Asparaginase encapsulated intact eryh4rocytes for treatment of acute lymphoblastic leukemia (ALL)" J. Controlled Release 139(3):182-189, 2009
• C. Moon, Y. M. Kwon, W. K. Lee, Y. J. Park, L. C. Chang, and V. C. Yang, "A novel polyrotaxane-based intracellular delivery system for camptoh4ecin: In vitro feasibility evaluation" J. Biomed. Mater. Res A. 84: 238-246, 2008
• C. Moon, Y. M. Kwon, W. K. Lee, Y. J. Park, and V. C. Yang, "In vitro assessment of a novel polyrotaxane-based drug delivery system integrated wih4 a cell-penetrating peptide." J. Control. Release 124:43-50, 2007
• Y. J. Park, L. C. Chang, J. F. Liang, C. Moon, C. P. Chung, and V. C. Yang, "Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: in vitro and in vivo study." FASEBJ. 19(11):1555-1557, 2005

특허

• E. Oh, C. Moon, and V.T. Nguyen, “Once-daily fixed-dose combination bilayer tablet comprising cilostazol and angiotensin receptor blockers and manufacturing method.” Patent No. KR101920309B1 (18-11-14)
• E. Oh, D.Q. Nguyen, and C. Moon, “Once-daily fixed-dose combination capsule formulations comprising sustained release cilostazol and immediate release statin minitablets and preparation method thereof.” Patent No. KR101920307B1 (18-11-14)
• E. Oh, D.Q. Nguyen, and C. Moon, “Formulation composition of once-daily fixed-dose combination bilayer tablets of cilostazol and clopidogrel and manufacturing method thereof.” Patent No. KR101843396B1 (18-03-23)

학력

• 학 사 : 수원대학교
• 석 사 : 성균관대학교
• 박 사 : 성균관대학교

주요경력

• 서울의과학연구소 유전성대사질환연구팀 연구원 및 팀장 (1997.2-2000.12)
• 성균관대학교 경기의약연구센터 선임연구원 (2002.10-2003.4).
• 성균관대학교 약학대학 연구부교수 (2004.8-2006.8)
• 아주대학교 의과대학 신경재생줄기세포연구소 연구부교수 (2006.9-2010.8)
• 아주대학병원 유전질환전문센터 참여교수 (2007.1-2012.2)
• 아주대학교 BK21 분자과학기술사업단 참여교수 (2008.9-2010.8)
• 교육과학기술부 국가기술수준평가 전문위원 (2010.5-2010.7)
• 아주대학교 분자과학기술학과 연구교수 (2010.8-2012.2)
• ㈜한국의약연구소 생물학적동등성시험 심사위원 (2010.11-2013.2)
• ㈜바이오토피아 미생물대사 연구 자문위원 (2011.9-2013.2)
• 한국유전학연구소-김숙자 소아청소년병원 연구자문위원 (2015.9-2018.8)
• 국립환경과학원-환경시험 검사기관 정도관리 기술위원회 위원 (2015.7-현재)
• 기초연구실지원사업-환경성호흡기질환 통합오믹스연구실 단장 (2015.9-2020.08)
• 순천대학교 생명약학연구소 연구소장 (2017.3-2019.2)
• 순천대학교 공동실험실습관 관장 (2019.5-2021.5)
• 순천대학교 약학대학 조교수, 부교수, 교수 (2012.2-현재)
• 순천대학교 약학대학 약학과 학과장 (2018.12-2019.7)
• 순천대학교 약학대학장 (2023.1-현재)

논문

• Lee H-S, Seo C, Hwang Y-H, Shin T-H, Park H-J, Kim Y, Ji M, Min J, Choi S, Kim H, Park A-K, Yee S-T, Lee G, Paik M-J (2019) Metabolomic approaches to polyamines including acetylated derivatives in lung tissue of mice with asthma. Metabolomics. 15(8) 1-9. (교신저자)
• Shin T-H, Seo C, Lee D-Y, Ji M, Manavalan B, Basith S, Chakkarapani S-K, Kang S-H, Lee G, Paik M-J, Park C-B (2019) Silica-coated magnetic nanoparticles induce glucose metabolic dysfunction in vitro via the generation of reactive oxygen species. Archives of Toxicology. 1-12. (공동교신저자)
• Kim H-A, Lee H-S, Shin T-H, Jung J-Y, Baek W-Y, Park H-J, G Lee, Paik M-J, Suh C-H (2018) Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever. Lupus (2018) 27, 930?938. (공동교신저자)
• Seo C, Na M, Jang J, Park M, Choi B, Lee S, Paik M-J (2018) Monitoring of altered amino acid metabolic pattern in rat urine following intraperitoneal injection with γ-hydroxybutyric acid. Metabolomics. 14(111) 1-8. (공동교신저자)
• Seo C, Hwang Y-H, Lee H-S, Kim Y, Shin T-H, Lee G, Son Y-J, Kim H, Yee S-T, Park A-K, Paik M-J (2017) Metabolomic study for monitoring of biomarkers in mouse plasma with asthma by gas chromatography-mass spectrometry. Journal of Chromatography B. 1063, 156-162. (공동교신저자)
• Seo C, Park M, Choi B, Lee S, Paik M-J (2016) Metabolomic analysis of urinary organic acids following intraperitoneal injection with γ-hydroxybutyric acid in rats. Metabolomics. 12 (190) 1-9. (공동교신저자)
• Shin T-H, Phukan G, Shim J-S, Nguyen D-T, Kim Y, Oh-Lee J-D, Lee H-S, Paik M-J, Lee G (2016) Restoration of Polyamine Metabolic Patterns in In Vivo and In Vitro Model of Ischemic Stroke following Human Mesenchymal Stem Cell Treatment. Stem Cells International. 2016, 1-11. (공동교신저자)
• Seo C, Hwang Y-H, Kim Y, Joo B-S, Yee S-T, Kim C-M, Paik M-J (2016) Metabolomic study of aging in mouse plasma by gas chromatography-mass spectrometry. Journal of Chromatography B. 1025, 1-6. (공동교신저자)
• Paik M-J, Kim H-S, Lee Y-S, Choi H-D, Pack J-K, Kim N, Ahn Y-H (2016) Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal. Amino Acids. 48 (1), 213-217. (공동교신저자)
• Hur H, Paik M-J, Xuan Y, Nguyen D-T, Ham I-H, Yun J, Cho Y-K, Lee G, Han S-U (2014) Quantitative measurement of organic acids in tissues from gastric cancer patients indicates increased glucose metabolism in gastric cancer. PLOS one, 9, 1-9. (공동 제1저자)
• Paik M-J, Kim D-K, Nguyen D-T, Lee G, Rhee C-S, Yoon I-Y, Kim J-W (2014) Correlation of daytime sleepiness with urine metabolites in patients with obstructive sleep apnea. 18(3) 517-523. (공동교신저자)
• Paik M-J, Kang J-S, Huang B-S, Carey J-R, Lee W (2013) Development and application of chiral crown ethers as selectors for chiral separation in high-performance liquid chromatography and nuclear magnetic resonance spectroscopy. Journal of Chromatography A. 1274, 1-5. (제1저자)
• Shim W-Y, Paik M-J, Nguyen D-T, Lee J-K, Lee Y, Ho Kim J-H, Shin E-H, Kang J-S, Jung H-S, Choi S, Park S, Shim J-S, Lee G (2012) Analysis of changes in gene ex-pression and metabolic profiles induced by silica-coated magnetic nanoparticles. ACS Nano, 6(9), 7665-7680. (공동 제1저자)
• Paik M-J, Kim H-S, Lee Y-S, Choi H-D, Pack J-K, Kim N, Ahn Y-H (2015) Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal. Amino Acids. In press
• Seo C, Yoon J, Rhee Y, Kim J-J, Name S-J, Lee W, Lee G, Yee S-T, Paik M-J (2015) Simultaneous analysis of seven 2-hydroxy fatty acids as tert-butyldimeh4ylsilyl derivatives in plasma by gas chromatography-mass spectrometry Biomedical Chromatography, 29, 156-160.
• Hur H, Paik M-J, Xuan Y, Nguyen D-T, Ham I-H, Yun J, Cho Y-K, Lee G, Han S-U (2014) Quantitative measurement of organic acids in tissues from gastric cancer patients indicates increased glucose metabolism in gastric cancer. PLOS one, 9, 1-9.
• Paik M-J, Kim D-K, Nguyen D-T, Lee G, Rhee C-S, Yoon I-Y, Kim J-W (2014) Correlation of daytime sleepiness wih4 urine metabolites in patients wih4 obstructive sleep apnea. Sleep Breah4, 18, 517-523.
• Paik M-J, Kang J-S, Huang B-S, Carey J-R, Lee W (2013) Development and application of chiral crown eh4ers as selectors for chiral separation in high-performance liquid chromatography and nuclear magnetic resonance spectroscopy. Journal of Chromatography A. 1274, 1-5.
• Nguyen D-T, Lee G, Paik M-J (2013) Keto acid profiling analysis as eh4oxime/tert-butyldimeh4ylsilyl derivatives by gas chromatography-mass spectrometry. Journal of Chromatography B, 913-914, 48-54.
• Shim W-Y+, Paik M-J+, Nguyen D-T, Lee J-K, Lee Y, Ho Kim J-H, Shin E-H, Kang J-S, Jung H-S, Choi S, Park S, Shim J-S, Lee G (2012) Analysis of changes in gene ex-pression and metabolic profiles induced by silica-coated magnetic nanoparticles. ACS Nano, 6(9), 7665-7680
• Nguyen D-T, Kim K-R, Lee G, and M-J Paik (2012) Chiral separation of N-meh4yl-DL-aspartic acid in rat brain tissue as N-eh4oxycarbonylated (S)-(+)-2-octylesterderivatives by GC-MS, Biomedical Chromatography, in press.
• Paik M-J, Shin J-Y, Lee G, and Ahn Y-H (2011)Monitoring of altered free fatty acid metabolic patterns in rat plasma following hemorrhagic stroke. Analytical Letters, 44, 1323-1332.
• Yu J, Han K-S. Lee G, Paik M-J, and Kim K-R (2010) Enantiomeric composition analysis of pranoprofen in equine plasma and urine by chiral liquid chromatography-tandem mass spectrometry in selected reaction monitoring mode, Journal of Chromatography B, 878, 3249-3254.
• Paik M-J, Ahn Y-H, Lee P-H, Kang H, Park C-B, Choi S, and Lee G (2010) Polyamine Patterns in h4e cerebrospinal fluid of patients wih4 Parkinson's disease and multiple system atrophy, Clinica Chimica Acta, 41, 1532-1535.
• Kim J-W, Lee G, Moon S-M, Park M-J, Hong S-K, Ahn Y-H, Kim K-R, and Paik M-J(2010) Metabolomic screening and star pattern recognition by urinary amino acid profile analysis from bladder cancer patients, Metabolomics, 6, 202-206.
• Paik M-J, Kim H, Lee J, Brand J, and Kim K-R (2009) Separation of triacylglycerols and free fatty acids in microalgal lipids by solid-phase extraction for separate fatty acid profiling analysis by gas chromatography, Journal of Chromatography A, 1216, 5917-5923.
• Paik M-J, Kuon D, Cho J, and Kim K-R (2009) Altered urinary polyamine patterns of cancer patients under acupuncture h4erapy, Amino Acids, 37, 407-413.
• Paik M-J, Li W-Y, Ahn Y-H, Lee P-H, Choi S, Kim K-R, Kim Y-M, Bang O-Y, and Lee G (2009) The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats, Clinica Chimica Acta, 402, 25-30.
• Yu J, Lee G, Jeong Y, Ahn Y-H, Hu M-B, Kim S-J, Kim K-R, and Paik M-J (2009) Enantiomeric Composition tests of ketoprofen in equine plasma and urine as diastereomeric (S)-(-)-1-phenyleh4ylamides by achiral GC-MS, Chromatographia, 69, 59-63.
• Paik M-J, Lee J, and Kim K-R (2008) N-Eh4oxycarbony-lation combined wih4 (S)-1- phenyleh4ylamidation for enantioseparation of amino acids by achiral gas chromato-graphy and gas chromatography?mass spectrometry, Journal of Chromatography A, 1214, 151?156.

학력

• 학 사 : 서울대학교
• 석 사 : 숙명여자대학교
• 박 사 : 성균관대학교

주요경력

• 서울대학교병원 인턴 약사
• 서울대학교병원 임상의학연구소 임상연구약사
• 서울대학교병원 약제부 조제과, 소아조제과, 주사조제계 주임약사
• ㈜ 한국얀센 메디칼부
• 보령제약㈜ 중앙연구소 수석연구원

논문

• Ghim J.-L., Paik S.H., Md. Hasanuzzaman, Chi Y.H., Choi H.G., Kim D.-H. Shin J.-G. 2015. Absolute Bioavailability and Pharmacokinetics of h4e Angiotensin II Receptor Antagonist Fimasartan in Healh4y subjects. J. Clin. Pharmacol. DOI: 10.1002/jcph.618.
• Kim T.H., Shin S., Landersdorfer C.B., Chi Y.H., Paik S.H., Myung J., Yadav R., Horkovics-Kovats S., Bulitta J.B., Shin B.S. 2015. Population Pharmacokinetic Modeling of h4e Enterohepatic Recirculation of Fimasartan in Rat, Dog and Human. AAPS Journal 17(5), 1210-1223.
• Kim T.H., Kim M.K., Kim M.G., Shin B.S., Kim K.-B., Lee J.B., Paik S.H., Yoo S.D. 2015. Simultaneous determination of phenoxyeh4anol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS wih4 polarity switching: application to ADME studies. Talanta 144, 29-38.
• Lee J.-Y., Choi Y.J., Oh S.J., Chi Y.H., Paik S.H., Lee K.H., Jung J.-K., Ryu C.S., Kim K.-B., Kim D.-H., Yoon Y.-R., Kim S.K. 2015. Characterization of fimasartan metabolites in human liver microsomes and human plasma. Xenobiotica, Published online: 11 Jun 2015. DOI:10.3109/00498254.2015.1047429
• Jeong E.-S., Kim Y.-W., Kim H.-J., Shin H.-J., Shin J.-G., Kim K.H., Chi Y.H., Paik S.H., Kim D.-H. 2015. Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3. Xenobiotica 45(1), 10-18.
• Kim, T.H., Shin, S., Bashir, M., Chi, Y.H., Paik, S.H., Lee, J.H., Choi, H.J., Choi, J.H., Yoo, S.D., Bulitta, J.B., 2014. Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats. Xenobiotica , 1-13.
• Chi, Y.H., Lee, J.H., Kim, J.H., Tan, H.K., Kim, S.L., Lee, J.Y., Rim, H.K., Paik, S.H., Lee, K.T., 2013. Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist. Biol. Pharm. Bull. 36(7), 1208-1215.
• Choi, M.J., Kwon, G.H., Han, N.S., Yoo, B.W., Kim, J.H., Paik, S.H., Chi, Y.H., Lee, K., Lee, J.Y., 2013. Development of 3D-QSAR CoMSIA models for 5-(biphenyl-2-yl)-1 H-tetrazole derivatives as angiotensin II receptor type 1 (AT 1) antagonists. Bioorg. Med. Chem. Lett. 23, 4540-4546.
• Ryu S., Shin J.-S., Cho Y.-W., Kim H.K., Paik S.H., Lee J.H., Chi Y.H., Kim J.H., Kim J.H., Lee K.-T. 2013. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synh4ase ex-pressions via nuclear factor-kappa b and activator protein-1 inactivation. Biol. Pharm. Bull. 36(3), 467-474.
• Choi, H., Choi, J., Lee, J.Y., Kim, J.H., Kim, J.H., Lee, J.K., Kim, G.I., Park, Y., Chi, Y.H., Paik, S.H., 2013. Synh4esis and evaluation of nicotinamide derivative as anti-angiogenic agents. Bioorg. Med. Chem. Lett. 23, 2083-2088.
• Kim, J.H., Lee, J.H., Paik, S.H., Kim, J.H., Chi, Y.H., 2012. Fimasartan, a novel angiotensin II receptor antagonist. Arch. Pharm. Res. 35, 1123-1126.
• Choi, H., Yoo, M., Choi, J., Lee, J.Y., Kim, J.H., Kim, J.H., Lee, J.K., Kim, G.I., Park, Y., Chi, Y.H., Paik S.H., Lee J.H., Lee K.-T., 2011. BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endoh4elial cells. Bioorg. Med. Chem. Lett. 21, 6236-6241.
• Chi, Y.H., Lee, H., Paik, S.H., Lee, J.H., Yoo, B.W., Kim, J.H., Tan, H.K., Kim, S.L., 2011. Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in h4e fasted and fed states in healh4y subjects. American Journal of Cardiovascular Drugs 11, 335-346.
• Shin, B.S., Kim, T.H., Paik, S.H., Chi, Y.H., Lee, J.H., Tan, H.K., Choi, Y., Kim, M., Yoo, S.D., 2011. Simultaneous determination of fimasartan, a novel antihypertensive agent, and its active metabolite in rat plasma by liquid chromatography-tandem mass spectrometry. Biomedical Chromatography 25, 1208-1214.

학력

• 학 사 : 동덕여자대학교 약학과 (2000) (전체 수석 입학)
• 석 사 : 숙명여자대학교 약학과 (2003)
• 박 사 : 영국 University of Nottingham 약학과 (2007) (전액 장학생)

주요경력

• 서울여자대학교 화학과 연구원 (2002)
• 독일 University of Hamburg-Eppendorf 교환대학원생 (한국연구재단 장학생) (2002)
• 일본 Tokyo Women's Medical University 박사 후 연구원 (2006-2007)
• 한국화학시험연구원 사업기획팀 4급 대리 (2007-2008)
• 대구한의대학교 한약재 약리학과 전임강사, 조교수 (2008-2011)
• 대구한의대학교 한약재 약리학과 학과장 (2010-2011)
• 국립순천대학교 약학과 조교수, 부교수, 정교수 (2011-현재)

논문

• Hong, C. E. and Lyu, S. Y. Mistletoe lectin induces apoptosis and modulates cell cycle in YD38 oral squamous cell carcinoma cells. BIOCELL. (2024, accepted)
• Hong, C. E. and Lyu, S. Y. Anticancer Mechanisms of Viscum album var. coloratum: A Study on B16BL6 and B16F10 Melanoma Cells. BIOCELL. (2024, accepted)
• Lyu, S. Y., Meshesha, S. M., and Hong, C. E. Synergistic Effects of Mistletoe Lectin and Cisplatin on Triple-Negative Breast Cancer Cells: Insights from 2D and 3D In Vitro Models. International Journal of Molecular Sciences. (2024, accepted)
• Hong, C. E. and Lyu, S. Y. Modulation of Breast Cancer Cell Apoptosis and Macrophage Polarization by Mistletoe Lectin in 2D and 3D Models. International Journal of Molecular Sciences. 25, 8459 (2024)
• Lim, W. T., Hong, C. E., and Lyu, S. Y. Investigating the Potential of Stellaria alsine var. undulata as a Cosmeceutical Ingredient. J. Korean Soc. Food Sci. Nutr. 53(3), 255-264 (2024)
• Lim, W. T., Hong, C. E., and Lyu, S. Y. The Antioxidant, Anti-aging, Immunomodulatory, and Whitening Effects of Moringa oleifera. J. Korean Soc. Food Sci. Nutr. 53(2), 138-148 (2024)
• Hong, C. E. and Lyu, S. Y. Inhibitory Effect of Mistletoe Ointment on DNCB-Induced Atopic Dermatitis in BALB/c Mice. Scientia Pharmaceutica. 92, 3 (2024)
• Hong, C. E. and Lyu, S. Y. Effect of Diospyros kaki extracts on atopic dermatitis-related cytokines. Food and Life. 2023(3), 77-84 (2023)
• Hong, C. E. and Lyu, S. Y. Anti-Atopic Dermatitis Effects of Acanthopanax divaricatus var. albeofructus Extracts. J. Korean Soc. Food Sci. Nutr. 52(12), 1233-1240 (2023)
• Lim, W. T., Hong, C. E., and Lyu, S. Y. Immuno-Modulatory Effects of Korean Mistletoe in MDA-MB-231 Breast Cancer Cells and THP-1 Macrophages. Scientia Pharmaceutica. 91, 48 (2023)
• Hong, C. E. and Lyu, S. Y. Anti-oxidant, Anti-aging, and Whitening Effects of Viscum album var. coloratum In vitro. 대한화장품학회지. 48(4), 295-302 (2022)
• Hong, C. E., Lim W. T., and Lyu, S. Y. Anti-inflammatory Activity of Viscum album var. coloratum In vitro. 대한화장품학회지. 48(3), 265-273 (2022)
• Hong, C. E. and Lyu, S. Y. Identification of Anti-oxidant, Anti-aging, and Whitening Effects of Diospyros kaki Extracts. 대한화장품학회지. 48(3), 275-285 (2022)
• Hong, C. E., and Lyu, S. Y. Effects of Three Korean Ginseng Extracts on Atopic Dermatitis-Related Cytokines, and Antioxidant and Anti-aging Activities. 생약학회지. 50(2), 102-111 (2019)
• Hong, C. E., and Lyu, S. Y. Anti-inflammatory and Antioxidant Effects of Ziziphus jujuba extracts. 생약학회지. 50(2), 86-95 (2019)
• Park, J. J., Hong, C. E., and Lyu, S. Y. Anti-oxidant and anti-inflammatory effects of Viscum album coloratum. Nat. Prod. Sci. (accepted) (2019)
• Hong, C. E., Han, S. Y., Kim, H. K., and Lyu, S. Y. Increased Th1 cytokine secretion by chiisanogenin and chiisanoside isolated from Acanthopanax chiisanensis. Yakhak Hoeji. 61, 344-349 (2017)
• Han, S. Y., Hong, C. E., Kim, H. K., and Lyu, S. Y. Anti-cancer effects of enteric-coated polymers containing mistletoe lectin in murine melanoma cells in vitro and in vivo. Mol. Cell Biochem. 408, 73-87 (2015)
• Hong, C. E., Park, A. K, and Lyu, S. Y. Synergistic anticancer effects of mistletoe lectin and doxorubicin in breast cancer cells. Mol. Cell Biochem. 394, 225-235 (2014)
• Hong, C. E. and Lyu, S. Y. Evaluation of the mutagenic properties of two lignans from Acanthopanax koreanum Nakai. Toxicol. Res. 29(4), 279-283 (2013)
• Oh, J., Hwang, I. H., Hong, C. E., Lyu, S. Y., and Na, M. K. Inhibition of fatty acid synthase by ginkgolic acids from the Leaves of Ginko biloba and their cytotoxic activity. J. Enzym. Inhib. Med. Ch. 28(3), 565-568 (2013)
• Lyu, S. Y., Choi, J. H., Lee, H. J., Park, W. B., and Kim, G.. J. Korean mistletoe lectin promotes proliferation and invasion of trophoblast through the regulation of the Akt signaling. Reprod. Toxicol. 39, 33-39 (2013)
• Lyu, S. Y., Shin, A. H., Hahn, D. R., and Park, W. B. Antioxidant activity of cyanidins isolated from Acanthopanax divaricatus var. albeofructus fruits in U937 macrophages. Food Sci. Biotech. 21(5), 1445-1450 (2012)
• Choi, J. H., Lyu, S. Y., Lee, H. J., Jung, J. E., Park, W. B., and Kim, G. J. Korean mistletoe lectin regulates self-renewel of the placenta-derived mesenchymal stem cells via autophagic mechanisms. Cell Prolif. 45(5), 420-429 (2012)
• Lyu, S. Y. and Park, W. B. Photoprotective potential of anthocyanins isolated from Acanthopanax divaricatus var. albeofructus fruits against UV irradiation in human dermal fibroblast cells. Biomol. Ther. 20(2), 201-206 (2012)
• Hong, C. E. and Lyu, S. Y. The anti-mutagenic Effect of Mistletoe Lectin (Viscum album L. var. coloratum agglutinin). Phytother. Res. 26, 787-790 (2011)
• Lyu, S. Y. and Park, W. B. Gene network analysis on the effect of Viscum album coloratum in T cell stimulated with anti-CD3/CD28 antibodies. Arch. Pharm. Res. 34(10), 1735-1749 (2011)
• Hong, C. E., Cho, M. C., Jang, H. A., and Lyu, S. Y. Mutagenicity and Anti- Mutagenicity of Acanthopanax divaricatus var. albeofructus. J. Toxicol. Sci. 36(5), 661-668 (2011)
• Hong, C. E., Ji, S. T., and Lyu, S. Y. Absence of mutagenic effects of three Nigerian medicinal plants, Bidens pilosa, Cleistopholis paterns, and Tetrapleura tetraptera. Trop. J. Pharm. Res. 10(2), 153-159 (2011)
• Hong, C. E and Lyu, S. Y. Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes. Immune Network 11(1), 42-49 (2011)
• Hong, C. E. and Lyu, S. Y. Genotoxicity study on five medicinal plants in Nigeria. J. Toxicol. Sci. 36(1), 87-93 (2011)
• Lyu, S. Y. and Park, W. B. Effect of Korean mistletoe lectin on gene ex-pression profile in human T lymphocytes: A microarray study. Biomol. Ther. 18(4), 411-419 (2010)
• Lyu, S. Y. and Park, W. B. Mistletoe Lectin Transport by M cells in Follicle Associated Epithelium (FAE) and IL-12 Secretion in Dendritic cells situated below FAE in vitro. Arch. Pharm. Res. 33(9), 1433-1441 (2010)
• Lyu, S. Y. and Park, W. B. Modulation of IL-12 and IFN-γ Secretions by Eleutheroside E, Tortoside A, and Syringaresinol from Acanthopanax koreanum Nakai. Biomol. Ther. 18(2), 211-218 (2010)
• Lyu, S. Y. and Park, W. B. Mistletoe lectin modulates intestinal epithelial cell-derived cytokines and B cell IgA secretion. Arch. Pharm. Res. 32(3), 443-51 (2009)
• Lyu, S. Y., and Park, W. B. Transport of Mistletoe lectin by M cells in human intestinal follicle-associated epithelium (FAE) in vitro. Arch. Pharm. Res. 31(12), 1613-1621 (2008)
• Lyu, S. Y., and Park, W. B. Th1/Th2 cytokine modulation in human PBMC by Acanthopanax divaricatus var. albeofructus. Food Sci. Biotech. 17(3), 631-636 (2008)
• Lyu, S. Y., Noh, B., and Park, W. B. Modulation of Th1/Th2 cytokine secretion in human peripheral blood mononuclear cells by water extract of Acanthopanax divaricatus var. albeofructus fruits. (Yakhak Hoeji. 52(1), 27-32 (2008)
• Lyu, S. Y., and Park, W. B. Effects of Korean Mistletoe Lectin (Viscum album coloratum) on proliferation and cytokine ex-pression in human peripheral blood mononuclear cells and T-lymphocytes. Arch. Pharm. Res. 30(10), 1252-1264 (2007)
• Shin, A. H., Lyu, S. Y., Noh. B., Kim, J. I., Kim, O. K., and Park, W. B. Antioxidative activity of extracts of Acanthopanax divaricatus var. albeofructus leaves in human dermal fibroblast irradiated UVA. Yakhak Hoeji. 51(4), 229-234 (2007)
• Khil, L. Y., Kim, W., Lyu, S. Y., Park, W. B., Jun, H. S., and Yoon, J. W. Mechanisms Involved in Korean Mistletoe Lectin-Induced Apoptosis of Colon Cancer Cells. World J. Gastroenterol. 13(2), 2811-2818 (2007)
• Lyu, S. Y. and W. B. Park. Mistletoe Lectin Modulates Proliferation and Cytokine ex-pressions in Murine Splenocytes. J. Biochem. Mol. Biol. 39(6), 662-670 (2006)
• Lyu, S. Y., Kim, J. Y., Noh, B. N., and Park, W. B. Antioxidative Activity of Water Extract of Different Parts of Acanthopanax divaricatus var. albeofructus. Yakhak Hoeji. 50(3), 191-198 (2006)
• Lyu, S. Y., Rhim, J. Y., and Park, W. B. Antiherpetic Activities of Flavonoids against Herpes Simplex Virus Type 1 (HSV-1) and Type 2 (HSV-2) in vitro. Arch. Pharm. Res. 28(11), 1293-1301 (2005)
• Lyu, S. Y., Moon. Y. S., and Park, W. B. Tyrosinase Inhibitory and Antioxidant Activities of Korean Mistletoe (Viscum album var. coloratum) Extract and Its Fractions. J. Food Sci. Nutr. 10(3), 244-250 (2005)
• Lyu, S. Y., and Park, W. B. Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. Arch. Pharm. Res. 28(5), 573-581 (2005)
• Lyu, S. Y., Kwon, Y. J., Joo, H. J., and Park, W. B. Preparation of alginate/chitosan microcapsules and enteric coated granules of mistletoe lectin. Arch. Pharm. Res. 27(1), 118-126 (2004)
• Choi, S. H., Lyu, S. Y., and Park, W. B. Mistletoe lectin-induced apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt. Arch. Pharm. Res. 27(1), 68-76 (2004)
• Lyu, S. Y., Moon, Y. S., Kwon, Y. J., Joo, H. J., and Park, W. B. Inhibition of porcine pancreatic elastase by Korean mistletoe (Viscum album var. coloratum) fractions. Nat. Prod. Sci. 9(4), 278-285 (2003)
• Lyu, S. Y., Rhim, J. Y., Moon, Y. S., Jung, S. H., Lee, K. Y., and Park, W. B. Antitumor activities of extract of Viscum album var. coloratum modified with Viscum album var. coloratum agglutinin. Nat. Prod. Sci. 8(4), 155-161 (2002)
• Rhim, J. Y., Moon, Y. S., Jung, S. H., Lee, K. Y., Lyu, S. Y., Shim, C. H., and Park, W. B. Antimicrobial activities of combined extract of Aloe vera with propolis against oral pathogens. J. Korean Soc. Food Sci. Nutr. 31(5), 899-904 (2002)
• Lyu, S. Y., Rhim, J. Y., Park, Y. H., Suh, K. B., and Park, W. B. Changes of lectin activity of kidney beans by heating and fermentation. . J. Korean Soc. Food Sci. Nutr. 31(1), 1-6 (2002)
• Lyu, S. Y., Choi, S. H., and Park, W. B. Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch. Pharm. Res. 25(1), 93-101 (2002)
• Park, W. B., Lyu, S. Y., Kim, J. H., Choi, S. H., Chung, H. K., Ahn, S. H., Hong, S. Y., Yoon, T. J., and Choi, M. J. Inhibition of tumor growth and metastasis by Korean mistletoe lectin is associated with apoptosis and antiangiogenesis. Cancer. Biother. Radio. 16(5), 439-447 (2001)
• Lyu, S. Y., Park, W. B., Choi, K. H., and Kim, W. H. Involvement of caspase-3 in apoptosis induced by Viscum album var. coloratum agglutinin in HL-60 cells. Biosci. Biotech. Biochem. 65(3), 534-541 (2001)
• Lyu, S. Y., Park, S. M., Choung, B. Y., and Park, W. B. Comparative study of Korean (Viscum album var. coloratum) and European mistletoes (Viscum album). Arch. Pharm. Res. 23(6), 592-598 (2000)
• Park, W. B., Choung, B. Y., Park, S. M., Kim, H. S., and Lyu, S. Y. Effects of drying process of mistletoes on cytotoxicities against cultures HL-60 and Molt-4 cells. Food Sci. and Biotechnol. 8(6), 391-396 (1999)

학력

• 학 사 : 경희대학교
• 석 사 : 서울대학교
• 박 사 : 서울대학교

주요경력

• 국립순천대학교 공동실험실습관 관장 (2023.04-현재)
• 국립순천대학교 약학대학 교수 (2023.03-현재)
• 국립순천대학교 바이오메디컬글로벌사업단 단장 (2021.08-현재)
• 국립순천대학교 약학대학 부교수 (2018.03-2023.02)
• 국립순천대학교 약학대학 학과장 (2022.01-2022.12)
• 국립순천대학교 약학대학 조교수 (2014.02-2018.02)
• 서울대학교 약학대학 연수연구원 (2013.09-2014.02)
• 서울대학교 종합약학연구소 Post-Doc (2012.09-2013.08)


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• 국가 천연물산업 표준화 기반 구축 사업 기획위원 (2021.06-현재)
• 지역산업진흥계획 바이오헬스케어산업 기획위원 (2021)
• 지역특화산업육성사업 기술닥터 (2020.10-현재)
• 지역수요맞춤형 R&D 기획연구(지역의 미래를 여는 과학기술) 기획위원 (2020)
• 전남생물산업진흥원 장비심의위원회 자문위원 (2020.01-현재)
• 순천 천연물 바이오산업 육성 연구용역 기획위원 (2019)
• 국제규격 천연물의약품원료 대량생산시설 운영위원 (2019.01-현재)
• 전남뷰티산업 기획위원 (2016.09-2017.12)
• 바이오상용기술고도화플랫폼 실증시험지원사업단 전문평가위원 (2015.05-2019.12)

논문

• Han S, Lim SL, Kim H, Choi H, Lee MY, Shim SY, Le DD, Ha IJ, Lee M, Lee SG. Ethyl acetate fraction of Osmanthus fragrans var. aurantiacus and its triterpenoids suppress proliferation and survival of colorectal cancer cells by inhibiting NF-κB and COX2. Journal of Ethnopharmacology 2024 (교신저자)
• Le DD, Yu S, Dang T, Lee M. Molecular Networking and Bioassay-Guided Preparation and Separation of Active Extract and Constituents from Vicia tenuifolia Roth. Antioxidants, 2023 Oct 18;12(10):1876 (교신저자)
• Yang MH, Lee M, Deivasigamani A, Le DD, Mohan CD, Hui KM, Sethi G, Ahn KS. Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model. Cancers. 2023 Sep 22;15(19):4681 (제1저자)
• Kim CK, Yu S, Lee M. Molecular networking-guided isolation strategy of a new C-glycosyl flavone rotamer from Stellaria alsine and evaluation of anti-inflammatory and antioxidant activities. Metabolomics. 2023 Sep 5;19(9):79 (교신저자)
• Le DD, Min KH, Lee M. Antioxidant and Anti-Inflammatory Capacities of Fractions and Constituents from Vicia tetrasperma. Antioxidants. 2023 May 4;12(5):1044 (교신저자)
• Kim CK, Yu J, Lee M. Molecular Networking-Guided Isolation of a Phenolic Constituent from Prunus mume Seed and Its Antioxidant and Anti-Inflammatory Activities. Foods. 2023 Mar 8;12(6):1146 (교신저자)
• Le DD, Han S, Yu J, Ahn J, Kim CK, Lee M. Iridoid derivatives from Vitex rotundifolia L. f. with their anti-inflammatory activity. Phytochemistry. 2023 Jun;210:113649 (교신저자)
• Jung YY, Ha IJ, Lee M, Ahn KS. Skin Improvement with Antioxidant Effect of Yuja (Citrus junos) Peel Fractions: Wrinkles, Moisturizing, and Whitening. Antioxidants. 2023, 12, 51. (교신저자)
• Yang MH, Ha IJ, Ahn J, Kim CK, Lee M, Ahn KS. Potential function of loliolide as a novel blocker of epithelial-mesenchymal transition in colorectal and breast cancer cells. Cell Signal. 2023 May;105:110610. (교신저자)
• Le D, Han S, Min KH, Lee M. Anti-Inflammatory Activity of Compounds Derived from Vitex rotundifolia. Metabolites. 2023 Feb 9;13(2):249. (교신저자)
• Le D, Ahn J, Han S, Lee SG, Lee M, Ha IJ. Phytochemical analysis and quality assessment of Podocarpus macrophyllus by UHPLC-DAD-ESI-MS and UHPLC-MS/MS MRM methods. Nat Prod Res. 2023 Feb 19:1-6. (교신저자)
• Choi KS, Shin TS, Ahn G, Kim SH, Chun J, Lee M, Kim DH, Choi HG, Lee KD, Shim SY. Bioactivity-Guided Fraction from Viscera of Abalone, Haliotis discus hannai Suppresses Cellular Basophils Activation and Anaphylaxis in mice. J Microbiol Biotechnol. 2024, Feb 28;34(2):379-386 (공동저자)
• Kim CK, Ahn J, Yu J, Le D, Han S, Lee M. Analysis of Antioxidant Constituents from Ilex rotunda and Evaluation of Their Blood-Brain Barrier Permeability. Antioxidants. 2022 Oct 6;11(10):1989. (교신저자)
• Kim CK, Yu J, Le D, Han S, Yu S, Lee M. Anti-inflammatory activity of caffeic acid derivatives from Ilex rotunda. Int Immunopharmacol. 2022 Dec 24;115:109610. (교신저자)
• Pham HT, Doan TP, Kim HW, Kim TW, Park SY, Kim H, Lee M, Kim KH, Oh WK, Lim YW, Kang KB. Cyclohumulanoid Sesquiterpenes Induced by the Noncompetitive Coculture of Phellinus orientoasiaticus and Xylodon flaviporus. J Nat Prod. 2022 Mar 25;85(3):511-518. (공동저자)
• Lee KD, Sun HJ, Lee M, Chun J, Shin TS, Choi KS, Shim SY. Ethanolic Extract of Pancake Mixture Powder Supplemented with Helianthus tuberosus Enhances Antidiabetic Effects via Inhibiting Inflammatory Mediator NO Production. Microbiol. Biotechnol. Lett. 2022, 50(2): 1?7. (공동저자)
• Le D, Han S, Ahn J, Yu J, Kim CK, Lee M. Analysis of Antioxidant Phytochemicals and Anti-Inflammatory Effect from Vitex rotundifolia L.f. Antioxidants (Basel). 2022 Feb 24;11(3):454. (교신저자)
• Le D, Lee YE, Lee M. Triterpenoids from the leaves of Osmanthus fragrans var. aurantiacus with their anti-melanogenesis and anti-tyrosinase activities. Nat Prod Res. 2022 Feb 8:1-7. (교신저자)
• Song HY, Jeong DE, Lee M. Bioactivity-Guided Extract Optimization of Osmanthus fragrans var. aurantiacus Leaves and Anti-Inflammatory Activities of Phillyrin. Plants 2021 Jul 28;10(8):1545. (교신저자)
• Kim C, Le D, Lee M. Diterpenoids Isolated from Podocarpus macrophyllus Inhibited the Inflammatory Mediators in LPS-Induced HT-29 and RAW 264.7 Cells. Molecules. 2021 Jul 17;26(14):4326. (교신저자)
• Shim SY, Lee M. Fermented product extract with Lentinus edodes attenuate the inflammatory mediators releases and free radical production. Natural Product Sciences. 27(2): 115-121 (2021) (교신저자)
• Shim SY, Lee YE, Lee M. Antioxidant Compounds, Kirenol and Methyl ent-16α, 17-dihydroxy-kauran-19-oate Bioactivity-Guided Isolated from Siegesbeckia glabrescens Attenuates MITF-Mediated Melanogenesis via Inhibition of Intracellular ROS Production. Molecules. 2021 Mar 30;26(7):1940. (교신저자)
• Tram LH, Van Thong N, Thuy LT, Anh NT, Minh NH, Minh TT, Thi Hong Phuong N, Ha TT, Nguyet Nguyen TM, Le DD, Hiep ND, Park JT, Thi To Chinh T, Thu Huong T, Lee M. Secondary metabolites from Valeriana jatamansi with their anti-inflammatory activity. Nat Prod Res. 2022 Sep;36(18):4620-4629. (공동저자)
• Shin J, Song HY, Lee M. Sudachinoid- and Ichangensin-Type Limonoids from Citrus junos Downregulate Pro-Inflammatory Cytokines. Int J Mol Sci. 2020 Sep 22;21(18):6963. (교신저자)
• Jeong DE, Shim SY, Lee M. Anti-inflammatory activity of phenylpropyl triterpenoids from Osmanthus fragrans var. aurantiacus leaves. Int Immunopharmacol. 2020 Sep;86:106576. (교신저자)
• Shim SY, Lee YE, Song HY, Lee M. p-Hydroxybenzoic Acid β-d-Glucosyl Ester and Cimidahurinine with Antimelanogenesis and Antioxidant Effects from Pyracantha angustifolia via Bioactivity-Guided Fractionation. Antioxidants (Basel). 2020 Mar 21;9(3):258. (교신저자)
• Lee M, Shim SY. Inhibitory Effects of Eriodictyol-7-O-β-d-glucuronide and 5,7-Dihydroxy-4-chromene Isolated from Chrysanthemum zawadskii var. latilobum in FcεRI-Mediated Human Basophilic KU812F Cell Activation. Molecules. 2020 Feb 23;25(4):994. (1저자)
• Shim SY, Kim JH, Kho KH, Lee M. Anti-inflammatory and anti-oxidative activities of lemon myrtle (Backhousia citriodora) leaf extract. Toxicol Rep. 2020 Jan 27;7:277-281. (교신저자)
• Kang KB, Woo S, Ernst M, van der Hooft JJJ, Nothias LF, da Silva RR, Dorrestein PC, Sung SH, Lee M. Assessing specialized metabolite diversity of Alnus species by a digitized LC-MS/MS data analysis workflow. Phytochemistry. 2020 May;173:112292. (교신저자)
• Jo A, Een Kim C, Lee M. Serratane triterpenoids isolated from Lycopodium clavatum by bioactivity-guided fractionation attenuate the production of inflammatory mediators. Bioorg Chem. 2020 Mar;96:103632. (교신저자)
• Jo A, Shin JH, Song HY, Lee YE, Jeong DE, Oh SH, Mun MJ, Lee M. Simultaneous determination of the flavonoids and limonoids in Citrus junos seed shells using a UPLC?DAD-ESI/MS. Natural Product Sciences. 26(1): 64-70 (2020) (교신저자)

학력

• 학 사 : 성균관대학교
• 석 사 : 성균관대학교
• 박 사 : 서울대학교

주요경력

• 순천대학교 약학대학장
• (사)대한약학회 부회장, 이사, 호남지부장
• 교육부(한국교육개발원) 대학구조개혁평가 후속 점검위원
• 순천대학교 기획부처장
• 순천대학교 생명약학연구소장
• 순천천연물의약소재개발연구센터 사무국장
• 순천대학교 약학대학 조교수, 부교수, 학과장
• 미국 NIH(NIDDK) Biotechnology Lab. Post-Doc.
• 울산대학교 의과대학 (서울아산병원) 연구교수
• ㈜종근당(바이오) 종합연구소 생물공학실 책임연구원(과장)

논문

• Lee Y, Jeong MH, Kim KJ, Baek SH, Hur JS, Son YJ. The extract of Ramalina litoralis inhibits osteoclast differentiation. Biotechnology and Bioprocess Engineering. 23:634-640. 2018
• Kim KJ, Jeong MH, Lee Y, Hwang SJ, Shin HB, Hur JS, Son YJ. Effect of usnic acid on osteoclatogenic activity. J. Clin. Med. 2018
• Hwang HG, Kim DH, Lee J, Mo Y, Lee SH, Lee Y, Hyeon JW, Cheon YP, Choi EK, Kim SY, Lee YS, Son YJ, Ryou C. High-Level Production of High-Purity Human and Murine Recombinant Prion Proteins Functionally Compatible to In Vitro Seeding Assay. J. Microbiol. Biotechnol. 28(10) 2018
• Kim KJ, Lee Y, Hwang HG, Sung SH, Lee M, Son YJ. Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1. J. Clin. Med. 2018
• Lee Y, Kim JE, Kim KJ, Cho SS, Son YJ. Optimized Extract from Corylopsis coreana Uyeki (Hamamelidaceae) Flos Inhibits Osteoclast Differentiation. Evid. Based Complement Alternat. Med. 2018
• Lee Y, Hwang YH, Kim KJ, Park AK, Paik MJ, Kim SH, Lee SU, Yee ST, Son YJ. Proteomic and transcriptomic analysis of lung tissue in OVA-challenged mice. Arch. Pharm. Res. 41(1):87-100. 2018
• Kim KJ, Lee YJ, Hwang YH, Kang KY, Yee ST, Son YJ. In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation. J. Clin. Med. 2017
• Hwang HG, Kim KJ, Lee SH, Kim CK, Min CK, Yun JM, Lee SU, Son YJ. Recombinant Glargine Insulin Production Process Using Escherichia coli. J. Microbiol. Biotechnol. 26(10):1781-1789. 2016
• Yeon JT, Kim H, Kim KJ, Lee J, Won DH, Nam SJ, Kim SH, Kang H, Son YJ. Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity. J. Nat. Prod. 79(7):1730-6. 2016
• Kim KJ, Leutou AS, Yeon JT, Choi SW, Kim SH, Yee ST, Choi KH, Nam SJ, Son YJ. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. Int. J. Endocrinol. 2015: 132436
• Kim KJ, Yeon JT, Choi SW, Moon SH, Ryu BJ, Yu R, Rark SJ, Kim SH, Son YJ. Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts. Bone 81:208-216. 2015
• Kim CK, Lee SB, Son YJ. Large-Scale Refolding and Enzyme Reaction of Human Preproinsulin for Production of Human Insulin. J. Microbiol. Biotechnol. 2015
• Yeon JT, Choi SW, Ryu BJ, Kim KJ, Lee JY, Byun BJ, Son YJ, Kim SH. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. J. Nat. Prod. 78(4):776-82. 2015
• Park SJ, Lee SH, Kim KJ, Kim SG, Kim H, Choe H, Lee SY, Yun JM, Cho JY, Chun J, Choi KS, Son YJ. Soluble ex-pression and purification of receptor activator of nuclear factor-kappa B ligand using Escherichia coli. J. Microbiol. Biotechnol. 25(2):274-9. 2015
• Yeon JT, Ryu BJ, Choi SW, Heo JC, Kim KJ, Son YJ, Kim SH. Natural polyamines inhibit h4e migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pah4ways. Amino Acids 46(11):2605-14. 2014
• Kim H, Kim KJ, Yeon JT, Kim SH, Won DH, Choi H, Nam SJ, Son YJ, Kang H. Placotylene A, an inhibitor of h4e receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp. Mar. Drugs 12(4):2054-65. 2014
• Yeon JT, Kim KJ, Choi SW, Moon SH, Park YS, Ryu BJ, Oh J, Kim MS, Erkhembaatar M, Son YJ, Kim SH. Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. PLoS One 9(2):e88974. 2014
• Druz A, Son YJ, Betenbaugh M, Shiloach J. Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metab. Eng. 16:87-94. 2013
• Min CK, Lee JW, Kim CK, Kim SH, Lee SY, Lee SM, Son YJ. Insulin related compounds and identification. J. Chromatogr. B 908:105-12. 2012
• Son YJ, Phue JN, Trinh LB, Lee SJ, Shiloach J. The role of Cra in regulating acetate excretion and osmotic tolerance in E.coli K-12 and E.coli B at high density growh4. Microbial Cell Factories. 10(52). 2011.
• Min CK, Son YJ, Kim CK, Park SJ, Lee JW. Increased ex-pression, folding and enzyme reaction rate of recombinant human insulin by selecting appropriate leader peptide. Journal of Biotechnology. 151(4):350-356. 2011
• Son YJ, Bae JY, Chong SH, Lee HS, Mo SH, Kim TY, Choe H. High cell density culture and purification of recombinant EC-SOD in Escherichia coli. Applied Biochemistry and Biotechnology. 162(6):1585-1598. 2010
• Son YJ, Kim CK, Kim YB, Kweon DH, Park YC, Seo JH. Effects of citraconylation on enzymatic modification of human proinsulin using trypsin and carboxypeptidase B. Biotechnology Progress. 25(4):1064-1070. 2009
• Lee HS, Son YJ, Chong SH, Bae JY, Leem CH, Jang YH, Choe H. Computational analysis of h4e quaternary structural changes induced by point mutations in human UDP-glucose dehydrogenase. Archives of Biochemistry and Biophysics. 486(1):35-43. 2009
• Son YJ, Kim CK, Choi BT, Park YC, Seo JH. Effects of β-mercaptoeh4anol and hydrogen peroxide on enzymatic conversion of human proinsulin to insulin. Journal of Microbiology and Biotechnology. 18(5):983-989. 2008
• Son YJ, Rha CS, Park YC, Shin SY, Lee YS, Seo JH. Production of cyclodextrins in ultrafiltration membrane reactor containing cyclodextrin glycosyl- transferase from Bacillus macerans. Journal of Microbiology and Biotechnology. 18(4):725-729. 2008
• Son YJ, Park KH, Lee SY, Oh SJ, Kim CK, Choi BT, Park YC, Seo JH. Effects of temperature shift strategies on human preproinsulin production in h4e fed-batch fermentation of recombinant Escherichia coli. Biotechnology and Bioprocess Engineering. 12(5):556-561. 2007

학력

• 학 사 : 동국대학교
• 석 사 : 동국대학교
• 박 사 : 서울대학교

주요경력

• 씨트리 신약개발연구소 선임연구원
• 서울대학교 종합약학연구소 선임연구원
• University of California, Los Angeles 박사후연구원

논문

• Kim, K.; Kim, S. J.; Han, Y. T.; Hong, S. J.; An, H.; Chang, D. J.; Ki, T.; Lim, B.; Lee, J.; Surh, Y. J.; Suh, Y. G. Identification of small molecule inhibitors of h4e STAT3 signaling pah4way: Insights into h4eir structural features and mode of action. Bioorg. Med. Chem. Lett. 2015, In Press.
• Lee, S.; An, H.; Chang, D. J.; Jang, J.; Kim, K.; Shim, J.; Lee, J.; Suh, Y. G. Total Synh4esis of (-)-deguelin via iterative pyran-ring formation. Chem. Comm. 2015, 51, 9026.
• Jo, D. H.; An, H.; Chang, D. J.; Baek, Y. Y.; Cho, C. S.; Jun, H. O.; Park, S. J.; Kim, J. H.; Lee, H. Y.; Kim, K. W.; Lee, J.; Park, H. J.; Kim, Y. M.; Suh, Y. G.; Kim, J. H. Hypoxia-Mediated Retinal Neovascularization and Vascular Leakage in Diabetic Retina is Suppressed by HIF-1α Destabilization by SH-1242 and SH-1280, Novel Hsp90 Inhibitor. J. Mol. Med. 2014, 92, 1083.
• Chang, D. J.; Kim, W. J. Discovery of structurally simplified analogs of colchicine as an immunosuppressant. Bioorg. Med. Chem. Lett. 2014, 24, 3121.
• Chang, D. J.; An, H.; Kim, K. S.; Park, J. W.; Kim, N. J.; Han, Y. T.; Yun, H.; Lee, S.; Lee, G.; Lee, S.; Cha, J. H.; Park, J. H.; Lee, S. C.; Kim, J. H.; Lee, H. Y; Kim, K. W.; Suh, Y. G. Design, Synh4esis and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein (HSP) 90 Inhibitors Targeting Proliferation and Angiogenesis. J. Med. Chem. 2012, 55, 10863.
• Chang, D. J.;Lee, S.; Jang, J.; Kim, S. O.; Kim, W. J.; Suh, Y. G. Part II. Development of Novel Colchicine-Derived Immunosuppressant wih4 Improved Pharmacokinetic Properties.Bioorg. Med. Chem.Lett. 2012, 22, 6750.
• Han, Y. T.; Choi, G. I.; Son, D.; Kim, N. J.; Yun, H.; Lee, S.; Chang, D. J.; Hong, H. S.; Kim, H.; Ha, H. J.; Kim, Y. H.; Park, H. J.; Lee, J.; Suh, Y. G. Ligand-Based Design, Synh4esis, and Biological Evaluation of 2-Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors. J. Med. Chem. 2012, 55. 9120
• Jang, J.; Jung, J. W.; Ahn, J; Shim, J,; Chang, D. J.; Kim, D. D.; Suh, Y. G. Asymmetric Formal Synh4esis of Schulzeines A and C. Org. Biomol. Chem. 2012, 10, 5202.Yun, H.; Kim, J.; Shim, J.; Lee, S.; Han, Y. T.; Chang, D. J.; Kim, D. D.; Suh, Y. G. Asymmetric Synh4eses of 1-Deoxy-6,8a-di-epi-castanospermine and 1-Deoxy-6-epi-castanospermine. J. Org. Chem. 2012, 77, 5389-5393.
• Chang, D. J.; Jeong, M.Y.; Song, J.; Chang, Y. J.; Suh, Y. G.; Kim, H. J.; Min, K. H. Discovery of Small Molecules h4at Enhance Astrocyte Differentiation in Rat Fetal Neural Stem Cells. Bioorg. Med. Chem. Lett. 2011, 21, 7050.
• Kim, N. J.; Moon, H.; Park, T.; Yun, H.; Jung, J. H.; Chang, D. J.; Kim, D. D.; Suh, Y. G. Concise and Enantioselective Total Synh4esis of 15-Deoxy-Δ12,14-Prostaglandin J2. J. Org. Chem., 2010,75, 7458.
• Lee, Y. S.; Jung, J. H.; Kim, S. H.; Jung, J. K.; Paek, S. M.; Kim, N. J; Chang, D. J.; Suh, Y. G. First Total Synh4esis and Structural Confirmation of Fluvirucinine A2 via an Iterative Ring Expansion Strategy. Org. Lett. 2010, 12, 2040.
• Paek, S. M.;Kim, N. J.; Shin, D.; Jung, J. K.; Jung, J. H.; Chang, D. J.; Suh, Y. G.A Concise Total Synh4esis of (+)-Tetrabenazine and (+)-α-Dihydrotetrabenazine. Chem- Eur. J. 2010, 16, 4623.
• Chang, D. J.; Yoon, E. Y.; Lee, G. B.; Kim, S. O.; Kim, W. J.; Kim, Y. M.; Jung, J. W.;  An, H.; Suh, Y. G. Design, Synh4esis and Identification of Novel Colchicine-Derived Immunosuppressant. Bioorg. Med. Chem. Lett. 2009, 19, 4416.
• Li, F.; Kim, N. J.; Chang, D. J.; Jang, J.; Jang, H.; Jung, J. W.; Min, K. H.; Jeong, Y. S.; Kim, S. Y.; Park, Y. H.; Kim, H. D.; Park, H. G.; Suh, Y. G. Synh4esis and Structural Optimization of Multiple H-Bonding Region of Diarylalkyl (h4io)amides as Novel TRPV1 Antagonists. Bioorgan. Med. Chem. 2009, 17, 8149.
• Paek, S. M.; Yun, H.; Kim, N. J.; Jung, J. H.; Chang, D. J.; Lee, S. J.; Yoo, J.; Park, H. J.; Suh, Y. G. Concise Synh4eses of (+)-Macrosphelides A and B: Studies on h4e Macro-Ring Closure Strategy. J. Org. Chem. 2009, 74, 554.
• Chang, D. J.; Kim, W. Y.; Hennessy, B.; Kang, H. J.; Yoo, J.; Han, S. H.; Kim, Y. S.; Park, H. J.; Seo, S. Y.; Mills, G.; Kim, K. W.; Hong, W. K.; Suh, Y. G.; Lee, H. Y. A Novel Derivative of h4e Natural Agent Deguelin for Cancer Chemoprevention and Therapy. Cancer Prev. Res. 2008, 1, 577.
• Suh, Y. G.; Kim, N. J.; Koo, B. W.; Lee, K. O.; Moon, S. H.; Shin, D. H.; Jung, J. H.; Paek, S. M.; Chang, D. J.; Li, F. Design, Synh4esis, and Biological Evaluation of Novel Constrained meta-Substituted Phenyl Propanoic Acids as Peroxisome Proliferator-Activated Receptor α and γ Dual Agonists. J. Med. Chem. 2008, 51, 6318.

학력

• 학사 : 조선대학교 약학대학 약학과, 순천향대학교 의료과학대학 의료생명공학과
• 석·박사 : 전남대학교 약학대학 약학과(생물약제학)

주요경력

• Guest Editor of SI on Pharmaceutics (Approaches to Individualized Drug Therapy Based on Population Pharmacometrics) (2022-2023)
• University at Buffalo, The State University of New York, Department of Pharmaceutical Sciences, Post-doctoral Fellowship (2021-2022)

논문

• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, Physiologically based pharmacokinetic (PBPK) modeling of lornoxicam: Exploration of doses for CYP2C9 genotypes and patients with cirrhosis, J. Pharm. Sci., In-press (2022)
• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, Development of physiologically-based toxicokinetic-toxicodynamic (PBTK-TD) model for 4-nonylphenol (4-NP) reflecting physiological changes according to age in males: Application as a new risk assessment tool with a focus on toxicodynamics, Environ. Pollut., In-press (2022)
• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, Drug delivery to the brain via the nasal route of administration: Exploration of key targets and major consideration factors, J. Pharm. Investig., In-press (2022)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Human risk assessment of 4-n-nonylphenol (4-n-NP) using physiologically-based pharmacokinetic (PBPK) modeling: Analysis of gender exposure differences and application to exposure analysis related to large exposure variability in population, Arch. Toxicol., 96(10), 2687-2715 (2022)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho*, Y.-B. Lee*, Population pharmacokinetic (Pop-PK) analysis of torsemide in healthy Korean males considering CYP2C9 and OATP1B1 genetic polymorphisms, Pharmaceutics, 14(4), 771 (2022)
• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, Population pharmacokinetic analysis of lornoxicam in healthy Korean males considering creatinine clearance and CYP2C9 genetic polymorphism, J. Pharm. Investig., 52 (1), 109-127 (2022)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Toxicokinetic studies of di-isobutyl phthalate focusing on the exploration of gender differences in rats, Chemosphere, 286, 131706 (2022)
• Phuong Tran, J.-H. Jang, S.-H. Jeong, Y.-B. Lee*, Oral and Lymphatic Delivery of Paclitaxel via Lipid Nanocapsules, Yakhak Hoeji, 65(5), 375-385 (2021) S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Toxicokinetics of di-isodecyl phthalate and its major metabolites in rats through the application of a developed and validated UHPLC-ESI-MS/MS method, Arch. Toxicol. 95, 3515-3537 (2021)
• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, Pharmacokinetic Comparison between Methotrexate-Loaded Nanoparticles and Nanoemulsions as Hard- and Soft-Type Nanoformulations: A Population Pharmacokinetic Modeling Approach, Pharmaceutics, 13(7), 1050 (2021)
• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, Oral delivery of topotecan in polymeric nanoparticles: lymphatic distribution and pharmacokinetics, J. Control. Release, 335, 86-102 (2021)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate, Arch. Toxicol., 95(7), 2385-2402 (2021)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho*, Y.-B. Lee*, Population pharmacokinetic analysis of cefaclor in healthy Korean subjects, Pharmaceutics, 13(5), 754 (2021)
• S.-H. Jeong, J.-H. Jang, D.-H. Jung, G.-Y. Lee, Y.-B. Lee*, Pharmacokinetic Changes According to Single or Multiple Oral Administrations of Socheongryong-Tang to Rats: Presented as a Typical Example of Changes in the Pharmacokinetics Following Multiple Exposures to Herbal Medicines, Pharmaceutics, 13(4), 478 (2021)
• S.-H. Jeong, J.-H. Jang, G.-Y. Lee, S.-J Yang, H.-Y. Cho, Y.-B. Lee*, In vivo and in vitro studies of Banhahoobak-tang tablets using UPLC-ESI-MS/MS with polarity switching, J. Pharm. Biomed. Anal., 196, 113931 (2021)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Pharmacokinetic comparison with different assays for simultaneous determination of cis-, trans-cefprozil diastereomers in human plasma, J. Pharm. Anal., 11(3), 351-363 (2021)
• S.-H. Jeong, J.-H. Jang, G.-Y. Lee, S.-J Yang, H.-Y. Cho, Y.-B. Lee*, Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study, J. Pharm. Anal., 11(4), 444-457 (2021)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Simultaneous determination of asarinin, β-eudesmol, and wogonin in rats using ultraperformance liquid chromatography?tandem mass spectrometry and its application to pharmacokinetic studies following administration of standards and Gumiganghwal-tang, Biomed. Chromatogr., 35(4), e5021 (2021)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Simultaneous determination of three iridoid glycosides of Rehmannia glutinosa in rat biological samples using a validated hydrophilic interaction-UHPLC-MS/MS method in pharmacokinetic and in vitro studies, J. Sep. Sci., 43(22), 4148-4161 (2020)
• J.-H. Jang, S.-H. Jeong, Y.-B. Lee*, Enhanced lymphatic delivery of methotrexate using W/O/W nanoemulsion: In vitro characterization and pharmacokinetic study, Pharmaceutics, 12(10), 978 (2020)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Toxicokinetics of diisobutyl phthalate and its major metabolite, monoisobutyl phthalate, in rats: UPLC-ESI-MS/MS method development for the simultaneous determination of diisobutyl phthalate and its major metabolite, monoisobutyl phthalate, in rat plasma, urine, feces, and 11 various tissues collected from a toxicokinetic study. Food. Chem. Toxicol., 145, 111747 (2020)
• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, Pharmacokinetic comparison of three different administration routes for topotecan hydrochloride in rats. Pharmaceuticals, 13(9), 231 (2020)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Simultaneous measurement of epinastine and its metabolite, 9,13b-dehydroepinastine, in human plasma by a newly developed ultra-performance liquid chromatography?tandem mass spectrometry and its application to pharmacokinetic studies, Biomed. Chromatogr., 34(9), e4848 (2020)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho*, Y.-B. Lee*, Risk assessment for humans using physiologically based pharmacokinetic model of diethyl phthalate and its major metabolite, monoethyl phthalate, Arch. Toxicol., 94(7), 2377-2400 (2020)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Population pharmacokinetic analysis of tiropramide in healthy Korean subjects. Pharmaceutics, 12(4), 374 (2020)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Pharmacokinetic comparison of epinastine using developed human plasma assays, Molecules, 25(1), 209 (2020)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, I.-J. Oh*, Y.-B. Lee*, A sensitive UPLC?ESI?MS/MS method for the quantification of cinnamic acid in vivo and in vitro: application to pharmacokinetic and protein binding study in human plasma. J. Pharm. Investig., 50(2), 159-172 (2020)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho*, Y.-B. Lee*, Gender differences in pharmacokinetics and tissue distribution of 4-n-nonylphenol in rats, Arch. Toxicol., 93(11), 3121-3139 (2019)
• J.-H. Jang, S.-H. Jeong, H.-Y. Cho, Y.-B. Lee*, Population pharmacokinetics of cis-, trans-, and total cefprozil in healthy male Koreans, Pharmaceutics, 11(10), 531 (2019)
• S.-H. Jeong, J.-H. Jang, G.-Y. Lee, S.-J Yang, H.-Y. Cho, Y.-B. Lee*, Simultaneous determination of fourteen main active components in Gumiganghwal-tang tablet by using a newly developed UPLC-ESI-MS/MS method, J. Chromatogr. B, 1126-1127, 121743 (2019)
• S.-H. Jeong, J.-H. Jang, Y.-B. Lee*, A novel and sensitive UPLC?MS/MS method to determine mequitazine in rat plasma and urine: Validation and its application to pharmacokinetic studies, Biomed. Chromatogr., 33(10), e4627 (2019)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Simultaneous determination of diethyl phthalate and its major metabolite, monoethyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study by ultrahigh performance liquid chromatography-tandem mass spectrometry, J. Pharm. Biomed. Anal., 173, 108-119 (2019).
• J.-H. Jang, S.-H. Jeong, Y.-B. Lee*, Preparation and in vitro/in vivo characterization of polymeric nanoparticles containing methotrexate to improve lymphatic delivery, Int. J. Mol. Sci., 20(13), 3312 (2019)
• J.-H. Jang, S.-H. Jeong, H.-Y. Cho, Y.-B. Lee*, Comparison of UPLC-MS/MS and HPLC-UV methods for the determination of zaltoprofen in human plasma, J. Pharm. Investig., 49(6), 613-624 (2019)
• S.-H. Jeong, J.-H. Jang, S.-H. Ham, S.-J Yang, H.-Y. Cho, Y.-B. Lee*, Simultaneous UPLC-MS/MS determination of four components of Socheongryong-tang tablet in human plasma: Application to pharmacokinetic study, J. Chromatogr. B, 1095, 214-225 (2018)
• S.-H. Jeong, J.-H. Jang, H.-Y. Cho, Y.-B. Lee*, Soft- and hard-lipid nanoparticles: a novel approach to lymphatic drug delivery, Arch. Pharm. Res., 41(8), 797-814 (2018)

학력

• 학사: 경희대학교 한약학과, 약학과
• 석 박사 통합: 연세대학교 제약의료 규제과학과 (임상의약학)

주요경력

• 지역약국 약국장
• 가천대학교길병원 병동 외래 약국
• 인하대학교병원 임상약제 지원파트
• 노인약료 전문약사
• 영양약료 전문약사
• 한국병원약사회 편집위원

논문

• Lee S, Yu YM, Han E, Park MS, Lee JH, Chang MJ. Effect of Pharmacist-Led Intervention in Elderly Patients through a Comprehensive Medication Reconciliation: A Randomized Clinical Trial. Yonsei Med J. 64(5):336-343.(2023)
• Lee, S. Potentially Inappropriate Medications and Regimen Complexity on Readmission of Elderly Patients with Polypharmacy: A Retrospective Study. Korean Journal of Clinical Pharmacy, 33(1), 1-7. (2023)
• Lee S, Jeong KH, Lee S, Park H. A Study on Types of Medication Adherence in Hypertension among Older Patients and Influencing Factors. Healthcare (Basel). Nov 20;10(11):2322. (2022)
• Lee, S., Kim, J. Effect of Pharmacy Practice Experience Training Using Clinical Role-Play in Learning. Journal of Korean Society of Health-System Pharmacists, 39(4), 488-497. (2022)
• Lee, S. The Present Status of Drug Administration via Enteral Route in a Tertiary Hospital: A Cross-Sectional Study. Journal of Korean Society of Health-System Pharmacists, 39(2), 185-192. (2022)
• Lee, S. Incidence of Potential Intravenous Drug Incompatibilities in the Intensive Care Units of a University Hospital. Journal of the Korean Society for Parenteral and Enteral Nutrition, 12(1), 14-20. (2020)
• Lee S, Jang J, Yang S, Hahn J, Min KL, Jung EH, Oh KS, Cho R, Chang MJ. Development and validation of the Korean version of the medication regimen complexity index. PLoS One. 16;14(5):e0216805.(2019)
• Lee, S. Development of a Two-Dimensional Compatibility Table for Intravenous Y-Site Drug Administration in a Neonatal Intensive Care Unit. Journal of Korean Society of Health-System Pharmacists, 37(1), 64-73. (2019)

학력

• 학사: 고려대학교 임상병리학과, 생명공학부
• 석 박사: 고려대학교 생명공학과 (분자생체공학)

주요경력

• 고려대학교 동물분자생체공학연구소 연구교수

논문

• Park H*, Lee JY*, Lim W, Song G. Benfuresate induces developmental toxicity in zebrafish larvae by generating apoptosis and pathological modifications. Pesticide Biochemistry and Physiology. 172:104751. (2021)
• Park H*, Lee JY*, Lim W, Song G. Therapeutic potential of α,β-thujone through metabolic reprogramming and caspase-dependent apoptosis in ovarian cancer cells. Journal of Cellular Physiology. 236(2):1545-1558. (2021)
• Park H*, Lee JY*, Lim W, Song G. Developmental toxicity of chlorpropham induces pathological changes and vascular irregularities in zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 236:108802. (2020)
• Park H, Park S*, Lee JY*, Song G, Lim W. Haloxyfop-P-methyl induces developmental defects in zebrafish embryos through oxidative stress and anti-vasculogenesis. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 233:108761. (2020)
• Park H, Lee JY*, Lim W, Song G. α,β-Thujone suppresses human placental choriocarcinoma cells via metabolic disruption. Reproduction. 159(6):745-756. (2020)
• Park H*, Lee JY*, Park S, Song G, Lim W. Developmental toxicity of fipronil in early development of zebrafish (Danio rerio) larvae: Disrupted vascular formation with angiogenic failure and inhibited neurogenesis. Journal of Hazardous Materials. 385:121531. (2020)
• Park H, Lim W, Song G. Ivermectin-induced programmed cell death and disruption of mitochondrial membrane potential in bovine mammary gland epithelial cells. Pesticide Biochemistry and Physiology. 163:84-93. (2020)
• Park H, Park S*, Lee JY*, Song G, Lim W. Bifenthrin induces developmental immunotoxicity and vascular malformation during zebrafish embryogenesis. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 228:108671. (2020)
• Park H*, Park HS*, Lim W, Song G. Ochratoxin A suppresses proliferation of Sertoli and Leydig cells in mice. Medical Mycology. 58(1):71-82. (2020)
• Park H*, Lee JY*, Park S, Song G, Lim W. Developmental toxicity and angiogenic defects of etoxazole-exposed zebrafish (Danio rerio) larvae. Aquatic Toxicology. 217:105324. (2019)
• Park H, Park S*, Lee JY*, Song G, Lim W. Toxic effects of flufenoxuron on development and vascular formation during zebrafish embryogenesis. Aquatic Toxicology. 216:105307. (2019)
• Park H*, Lim W*, You S, Song G. Fenbendazole induces apoptosis of porcine uterine luminal epithelial and trophoblast cells during early pregnancy. Science of The Total Environment. 681:28-38. (2019)
• Park H*, Lim W*, You S, Song G. Oxibendazole induces apoptotic cell death in proliferating porcine trophectoderm and uterine luminal epithelial cells via mitochondria-mediated calcium disruption and breakdown of mitochondrial membrane potential. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 220:9-19. (2019)
• Park H*, Park S*, Bazer FW, Lim W, Song G. Myricetin treatment induces apoptosis in canine osteosarcoma cells by inducing DNA fragmentation, disrupting redox homeostasis, and mediating loss of mitochondrial membrane potential. Journal of Cellular Physiology. 233(9):7457-7466. (2018)