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  • 김민선 교수 (Kim, Min-Sun)

    김민선교수 (Kim, Min-Sun)

    전공
    독성학
    강의과목
    약물학, 독성학
    전화번호
    061) 750-3756
    이메일
    minsun@scnu.ac.kr

    학력

    • 학 사 : 부산대학교
    • 석 사 : 부산대학교
    • 박 사 : 미국 오레곤 주립대학

    주요경력

    • 식품의약품안전청 의약품심사부 소화계약품과 심사관
    • 영남대학교 의과대학 연구교수
    • 미국 컴언웰스대학교 의과대학 Post-Doc.
    • 미국 오레곤건강과학대학교 독성학센터 Post-Doc.

    논문

    • Sung B, Park S, Ha YM, Kim DH, Park CH, Jung KJ, Kim MS, Kim YJ, Kim MK, Moon JO, Yokozawa T, Kim ND, Yu BP, Chung HY. Salicylideneamino-2-h4iophenol modulates nuclear factor-κB h4rough redox regulation during h4e aging process. Geriatr Gerontol Int. 15(2):211-9. 2015
    • Kim H1, Yang I, Patil RS, Kang S, Lee J, Choi H, Kim MS, Nam SJ, Kang H. Anih4iactins A-C, modified 2-phenylh4iazoles from a mudflat-derived Streptomyces sp. J Nat Prod. 77(12):2716-9. 2014.
    • Nugroho A, Rhim TJ, Choi MY, Choi JS, Kim YC, Kim MS, Park HJ. Simultaneous analysis and peroxynitrite-scavenging activity of galloylated flavonoid glycosides and ellagic acid in Euphorbia supina. Arch Pharm Res. 37(7):890-8. 2014.
    • Jung HA1, Jung HJ, Jeong HY, Kwon HJ, Kim MS, Choi JS. Anti-adipogenic activity of h4e edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 37(6):713-20. 2014.
    • Ji ST, Kim MS, Park HR, Lee E, Lee Y, Jang YJ, Kim HS, Lee J. Diallyl disulfide impairs hippocampal neurogenesis in h4e young adult brain. Toxicol Lett. 221(1):31-8. 2013.
    • Kim DH, Chung JH, Yoon JS, Ha YM, Bae S, Lee EK, Jung KJ, Kim MS, Kim YJ, Kim MK, Chung HY. Ginsenoside Rd inhibits h4e ex-pressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver. J Ginseng Res. 37(1):54-63. 2013.
    • Lee Y, Oh SB, Park HR, Kim HS, Kim MS, Lee J. Selective impairment on h4e proliferation of neural progenitor cells by oxidative phosphorylation disruption. Neurosci Lett. 535:134-9. 2013.
    • Kim HJ, Lee EK, Park MH, Ha YM, Jung KJ, Kim MS, Kim MK, Yu BP, Chung HY. Ferulate protects h4e epih4elial barrier by maintaining tight junction protein ex-pression and preventing apoptosis in tert-butyl hydroperoxide-induced Caco-2 cells. Phytoh4er Res. 27(3):362-7. 2013.
    • Kim MS, Park HR, Chung HY, Kim HS, Yu BP, Yang HS, Lee J. Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Chem Biol Interact. 194(2-3):139-47. 2011
    • Park HR, Kim MS, Kim SJ, Park M, Kong KH, Kim HS, Kwack SJ, Kang TS, Kim SH, Kim HS, Lee J. Acrylamide induces cell deah4 in neural progenitor cells and impairs hippocampal neurogenesis. Toxicol Lett. 1;193(1):86-93. 2010.
    • Hong SE, Heo HS, Kim DH, Kim MS, Kim CH, Lee J, Yoo MA, Yu BP, Leeuwenburgh C, Chung HY. Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome. Age (Dordr):32(1):15-30. 2010.
    • Park MJ, Lee EK, Heo HS, Kim MS, Sung B, Kim MK, Lee J, Kim ND, Anton S, Choi JS, Yu BP, Chung HY. The anti-inflammatory effect of kaempferol in aged kidney tissues: h4e involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinase pah4ways. J Med Food. 12(2):351-8. 2009
    • Kim MS, Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, Kim SH, Lee J. Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. Toxicology. 16:260(1-3):97-103. 2009.
    • Son TG, Park HR, Kim SJ, Kim K, Kim MS, Ishigami A, Handa S, Maruyama N, Chung HY, Lee J. Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage h4rough ERK-mediated astrocytosis. J Neurosci Res. 87(13):2890-7. 2009.
    • Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in h4e adult hippocampus. J Biol Chem. 283:14497-505. 2008
    • Kim MS, Kim MK, Kim KS, Chung JH, Kim SJ, Kim JH, Kim JR, Lee J, Yu BP, Chung HY. Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress.Toxicology 243:216-23, 2008.
    • Kim, K. S., Kim, M. S., Seu, Y. B., Chung, H. Y., Kim, J. H., Kim, J. R. Regulation of replicative senescence by insulin-like growh4 factor-binding protein 3 in human umbilical vein endoh4elial cells. Aging Cell. 6:535-45, 2007.
    • Kim MK, Kim KS, Chung JH, Kim JH, Kim JR, Chung HY, Kim MS. Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity h4rough ROS generation in HUVEC cells. J Toxicol Environ Healh4 A 70:1336-43, 2007
  • 김항건 교수 (Kim, Hangun)

    김항건교수 (Kim, Hangun)

    전공
    병태생리학
    강의과목
    해부생리학, 병태생리학, 보건의약관계법규
    전화번호
    061) 750-3761
    이메일
    hangunkim@scnu.ac.kr

    학력

    • 학 사 : 전남대학교 약학대학 약학과
    • 석 사 : 전남대학교 약학대학(병태생리학)
    • 박 사 : 전남대학교 약학대학(병태생리학)

    주요경력

    • Guest Editor of SI on IJMS
    • EBM of Scientific Reports, Oncology Letters, International Journal of Molecular Sciences (IJMS)
    • 약학회지 편집간사
    • 대한약학회 학술간사
    • 미국암학회(AACR) 정회원
    • 한국분자세포생물학회 뉴스지편집위원
    • 대한약리학회 학술위원/대외협력위원/재무부위원장
    • 한국독성학회/한국환경성돌연변이발암원학회 전남지부장
    • 순천대학교 교수회 제20기 교수평의회 평의원
    • 순천대학교 생명약학연구소장
    • (재)순천천연물의약소재개발연구센터 사무국장
    • 순천대학교 약학대학 약학과 전임강사, 조교수, 부교수(2011-현재)
    • 전남대학교 의과대학 약리학교실 박사후연구원(2010-2011)

    논문

  • 김훈 교수 (Kim, Hoon)

    김훈교수 (Kim, Hoon)

    전공
    생화학
    강의과목
    약품생화학
    전화번호
    061) 750-3751
    이메일
    hoon@scnu.ac.kr

    학력

    • 학 사 : 서울대학교
    • 석 사 : 한국과학기술원
    • 박 사 : 한국과학기술원

    주요경력

    • 순천대학교 약학대학장
    • 순천천연물의약소재개발연구센터장
    • 순천대학교 생명약학연구소장
    • 대한약학회 부회장, 이사, 호남지부장
    • 친환경바이오산업 전문인력 양성사업단 총괄팀장
    • 순천대학교 농업과학연구소장
    • 순천대학교 농업생명과학대학 교학부장
    • 미국 미시간주립대학(MSU)방문교수
    • 미국 캘리포니아대학(샌프란시스코) Post-Doc
    • 순천대학교 전임강사, 조교수, 부교수, 교수, 학과장

    논문

    • Bijo Mathew, Della Grace Thomas Parambi, Githa Elizabeth Mathew, Md. Sahab Uddin, Sini T. Inasu, Hoon Kim, Akash Marathakam, M. K. Unnikrishnan, Simone Carradori, “Therapeutic potentials of dual-acting monoamine oxidase inhibitors in Alzheimer’s and Parkinson’s diseases”, (2019. 9. 3 Online) Archiv der Pharmazie. e1900177.
    • Seetha Harilal, Jobin Jose, Della Grace Thomas Parambi, Rajesh Kumar, Githa Elizabeth Mathew, Md. Sahab Uddin, Hoon Kim and Bijo Mathew, “Advancements in nanotherapeutics for Alzheimer’s disease: current perspectives”, (2019. 7. 15 Online; 9. 1) Journal of Pharmacy and Pharmacology, 71, 1370–1383.
    • Jong Min Oh, Myung-Gyun Kang, Ahreum Hong, Ji-Eun Park, Soo Hyun Kim, Jae Pil Lee, Seung Cheol Baek, Daeui Park, Sang-Jip Nam, Myoung-Lae Cho, Hoon Kim, “Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives”, (2019. 7. 2 Online; 9. 15) International Journal of Biological Macromolecules. 137, 426-432.
    • Jae Pil Lee, Myung-Gyun Kang, Joon Yeop Lee, Jong Min Oh, Seung Cheol Baek, Hyun Hee Leem, Daeui Park, Myoung-Lae Cho, Hoon Kim, “Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds”, Bioorganic Chemistry (2019. 6. 6 Online; 8. 1) 89, 103043.
    • Balasubramanian Lakshminarayanan, Seung Cheol Baek, Jae Pil Lee, Nagappan Kannappan, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Thillainayagam Subburaju, Hoon Kim, Bijo Mathew, “Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors”, (2019. 6. 6) Chem Select 4, 6614-6619.
    • Bijo Mathew, Seung Cheol Baek, Della Grace Thomas Parambi, Jae Pil Lee, Githa Elizabeth Mathew, Sivaraman Jayanthi, Vinod Devaraji, Clariya Rapheal, V. Devikrishna, K. Shain Shad, Md. Sahab Uddin, Hoon Kim, “Potent and highly selective dual-targeting monoamine oxidase-B inhibitors: Fluorinated chalcones of morpholine versus imidazole”, Archiv der Pharmazie (2019. 1. 21 Online; 4. 1). e1800309.
    • Seung Cheol Baek, Myung-Gyun Kang, Ji-Eun Park, Jae Pil Lee, Hanna Lee, Hyung Won Ryu, Chul Min Park, Daeui Park, Myoung-Lae Cho, Sei-Ryang Oh, Hoon Kim, “Osthenol, a Prenylated Coumarin, as a Monoamine Oxidase A Inhibitor with High Selectivity”, (2019. 01. 18 Online; 3. 15) Bioorganic & Medicinal Chemistry Letters. 29, 839-843.
    • Jong Min Oh, Yi Jeong Kim, Hyo-Seung Gang, Jin Han, Hyung-Ho Ha, Hoon Kim, “Antimicrobial activity of divaricatic acid isolated from the lichen Evernia mesomorpha against methicillin-resistant Staphylococcus aureus”, (2018. 11. 23) Molecules. 23, 3068.
    • Seung Cheol Baek, Mi Hyeon Park, Hyung Won Ryu, Jae Pil Lee, Myung-Gyun Kang, Daeui Park, Chul Min Park, Sei-Ryang Oh, Hoon Kim, “Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A”, (2018. 10. 28 Online; 2019. 03. 01) Bioorganic Chemistry. 83, 317–325.
    • Jae Pil Lee, Eun-Sun Shin, Min Yeol Cho, Kyung-Dong Lee, and Hoon Kim, “Roles of carbohydrate-binding module (CBM) of an endo-β-1,4-glucanase (Cel5L) from Bacillus sp. KD1014 in thermostability and small-substrate hydrolyzing activity”, (2018. 10. 26 Online; 12. 28) J. Microbiol. Biotechnol. 28, 757-764.
    • Bijo Mathew, Seung Cheol Baek, Della Grace Thomas Parambi, Jae Pil Lee, Monu Joy, P. R. Annie Rilda, Rugma V. Randev, P. Nithyamol, Vijitha Vijayan, Sini T. Inasu, Githa Elizabeth Mathew, Krishnakumar K. Lohidakshan, Girish Kumar Krishnan, Hoon Kim, “Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors”, (2018. 9. 25 Online; 2018. 11. 1) MedChemComm. 1871-1881.
    • Rani Sasidharan, Seung Cheol Baek, Sreedharannair Leelabaiamma Manju, Hoon Kim, Bijo Mathew, “Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors”, (2018. 06. 23 Online; 10. 1) Biomedicine & Pharmacotherapy. 106, 8-13.
    • Seung Cheol Baek, Hyung Won Ryu, Myung-Gyun Kang, Hanna Lee, Daeui Park, Myoung-Lae Cho, Sei-Ryang Oh, Hoon Kim, “Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid”, (2018. 06. 18 Online; 08. 01) Bioorganic & Medicinal Chemistry Letters. 28, 2403-2407.
    • Jae Pil Lee, HyunWoo Lee, Han Beur Na, Jun-Hee Lee, Yeo-Jin Hong, Jeong-Min Jeon, Eun Ju Kwon, Sung Kyum Kim, Hoon Kim, “Characterization of truncated endo-β-1,4-glucanases from a compost metagenomic library and their saccharification potentials”, (2018. 04. 23 Online; 08. 01) International Journal of Biological Macromolecules 115, 554–562.
    • Jae Pil Lee, Yoon A Kim, Sung Kyum Kim, Hoon Kim, “Characterization of a multimodular endo-β-1,4-glucanase (Cel9K) from Paenibacillus sp. X4 with a potential additive for saccharification”, (2018. 02. 01 Online; 04. 27) J. Microbiol. Biotechnol. 28, 588-596.
    • Seung Cheol Baek, Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Soo Hyun Kim, Myoung-Lae Cho, Sei-Ryang Oh, Hoon Kim, “Selective inhibition of monoamine oxidase A by hispidol”, (2018. 01. 31 Online; 02. 15) Bioorganic & Medicinal Chemistry Letters. 28, 584-588.
    • Jong Min Oh, Jae Pil Lee, Seung Cheol Baek, Seul Gi Kim, Yang Do Jo, Jungho Kim, Hoon Kim, “Characterization of two extracellular β-glucosidases produced from the cellulolytic fungus Aspergillus sp. YDJ216 and their potential applications for the hydrolysis of flavone glycosides”, (2018. 01. 12 Online; 05. 01) International Journal of Biological Macromolecules. 111, 595-603.
    • Jerad Suresh, Seung Cheol Baek, Surya Parakkot Ramakrishnan, Hoon Kim, Bijo Mathew, “Discovery of potent and reversible MAO-B inhibitors as furanochalcones”, (2017. 11. 28 Online; 2018. 03. 01) International Journal of Biological Macromolecules. 108, 660-664.
    • Yu Jin Jeong, Seung Cheol Baek, Hoon Kim, “Cloning and characterization of a novel intracellular serine protease (IspK) from Bacillus megaterium with a potential additive for detergents”, (2017. 10. 31 Online; 2018. 03. 01) International Journal of Biological Macromolecules. 108, 808-816.
    • Hyun Woo Lee, Hyung Won Ryu, Seung Cheol Baek, Myung-Gyun Kang, Daeui Park, Hyoung-Yun Han, Ju Hyeon An, Sei-Ryang Oh, Hoon Kim, “Potent inhibitions of monoamine oxidase A and B by acacetin and its 7-O-(6-O-malonylglucoside) derivative from Agastache rugosa”, (2017. 06. 19 Online; 11. 01) International Journal of Biological Macromolecules. 104, 547-553.
    • Seung Cheol Baek, Thien-Hoang Ho, Hyun Woo Lee, Won Kyeong Jung, Hyo-Seung Gang, Lin-Woo Kang, Hoon Kim, “Improvement of enzyme activity of β-1,3-1,4-glucanase from Paenibacillus sp. X4 by error-prone PCR and structural insights of mutated residues”, (2017. 05. 15; 02. 08 Online) Applied Microbiology and Biotechnology. 101, 4073-4083.
    • Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Sei-Ryang Oh, Hoon Kim, “Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone”, (2017. 01. 31 Online; 03. 01) Bioorganic & Medicinal Chemistry Letters. 27, 1136-1140.
    • Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Hanna Lee, Heung Mook Shin, Sei-Ryang Oh, Hoon Kim, “Potent inhibition of monoamine oxidase A by decursin from Angelica gigas Nakai and by wogonin from Scutellaria baicalensis Georgi”, (2017. 01. 18 Online; 04. 01) International Journal of Biological Macromolecules. 97, 598-605.
    • Mi-Jeong Yang, Hyun Woo Lee, and Hoon Kim, “Enhancement of thermostability of Bacillus subtilis endoglucanase by error-prone PCR and DNA shuffling”, (2017. 01. 16 Online; 02. 28) Applied and Biological Chemistry. 60, 73-78.
    • Hyun Woo Lee, Hansol Choi, Sang-Jip Nam, William Fenical, Hoon Kim, “Potent Inhibition of Monoamine Oxidase B by a piloquinone from marine-derived Streptomyces sp. CNQ-027”, (2017. 01. 09 Online; 04. 28) J. Microbiol. Biotechnol. 27, 785-790.
    • Hyun Woo Lee, Yeon Ji Kim, Sang-Jip Nam, and Hoon Kim, “Potent selective inhibition of monoamine oxidase A by alternariol monomethyl ether isolated from Alternaria brassicae”, (2016. 11. 14 Online; 2017. 02. 28) J. Microbiol. Biotechnol. 27, 316-320.
    • Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Sei-Ryang Oh, and Hoon Kim, “Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens”, (2016. 08. 18 Online; 10. 01) Bioorganic & Medicinal Chemistry Letters. 26, 4714-4719.
    • Hyun Woo Lee, Won Kyeong Jung, Yong Ho Kim, Bum Han Ryu, T. Doohun Kim, Jungho Kim, and Hoon Kim, “Characterization of a novel alkaline family VIII esterase with S-enantiomer preference from a compost metagenomic library”, (2016. 02) J. Microbiol. Biotechnol. 26, 315-325.
    • Hee Jung Kim, Won Kyeong Jung, Hyun Woo Lee, Wanki Yoo, T. Doohun Kim, and Hoon Kim, “Characterization of an alkaline family I.4 lipase from Bacillus sp. W130-35 isolated from a tidal mud flat with broad substrate specificity”, (2015. 12) J. Microbiol. Biotechnol. 25, 2024–2033.
    • Hyun Woo Lee, Won Kyeong Jung, Hee Jung Kim, Yu Seok Jeong, Sang-Jip Nam, Heonjoong Kang, and Hoon Kim, "Inhibition of monoamine oxidase by anithiactins from Streptomyces sp.", (2015. 09) J. Microbiol. Biotechnol. 25, 1425–1428.
    • Hee Jung Kim, Yu Seok Jeong, Won Kyeong Jung, Sung Kyum Kim, Hyun Woo Lee, Hyung-Yeel Kahng, Jungho Kim, and Hoon Kim, "Characterization of novel family IV esterase and family I.3 lipase from an oil-polluted mud flat metagenome", (2015. 09) Mol Biotechnol 57, 781–792.
    • Han Beur Na, Won Kyeong Jung, Yu Seok Jeong, Hee Jung Kim, Sung Kyum Kim, Jungho Kim, Han Dae Yun, Jung-Kul Lee, and Hoon Kim, "Characterization of a GH family 8 b-1,3-1,4-glucanase with distinctive broad substrate specificity from Paenibacillus sp. X4", (2015. 03) Biotechnol Lett 37, 643-655.
    • Sung Kyum Kim, Yong Ho Kim, Yu Seok Jeong, Han Beur Na, Jungho Kim, Keun Sik Baik, Han Dae Yun, Jung-Kul Lee, and Hoon Kim, "Chitinibacter suncheonensis sp. nov., a chitinolytic bacterium from a mud flat in Suncheon Bay", (2012. 12) The Journal of Microbiology 50(6): 1058–1062.
    • Nguyen Dinh Phuong, Yu Seok Jeong, Thangaswamy Selvaraj, Sung Kyum Kim, Yong Ho Kim, Kyung Hwa Jung, Jungho Kim, Han Dae Yun, Sui-Lam Wong, Jung-Kul Lee, and Hoon Kim, "Production of XynX, a large multimodular protein of Clostridium thermocellum, by protease-deficient Bacillus subtilis strains", (2012. 09) Appl Biochem Biotechnol 168:375–382. Erratum: “Production of XynX, a Large Multimodular Protein of Thermoanaerobacterium sp., by Protease-Deficient Bacillus subtilis Strains”, (2012. 11) Appl Biochem Biotechnol 168:1349–1350.
    • Yu Seok Jeong, Han Beur Na, Sung Kyum Kim, Yong Ho Kim, Eun Ju Kwon, Jungho Kim, Han Dae Yun, Jung-Kul Lee, and Hoon Kim. “Characterization of Xyn10J, a novel family 10 xylanase from a compost metagenomic library”, (2012. 03) Appl Biochem Biotechnol 166:1328–1339.
    • Thangaswamy Selvaraj, Sung Kyum Kim, Yong Ho Kim, Yu Seok Jeong, Yu-Jeong Kim, Nguyen Dinh Phuong, Kyung Hwa Jung, Jungho Kim, Han Dae Yun, and Hoon Kim, “The role of carbohydrate-binding module (CBM) repeat of a multimodular xylanase (XynX) from Clostridium thermocellum in cellulose and xylan binding”, (2010, 12) J. Microbiol. 48(6), 856-861.
    • Yong Ho Kim, Eun Ju Kwon, Sung Kyum Kim, Yu Seok Jeong, Jungho Kim, Han Dae Yun, and Hoon Kim, “Molecular cloning and characterization of a novel family VIII alkaline esterase from a compost metagenomic library”, (2010.02), Biochemical and Biophysical Research Communications. 393, 45-49.
    • Seur Kee Park, Chi Wook Kim, Hoon Kim, Jae Sung Jung, and G. E. Harman. “Cloning and high-level production of a chitinase from Chromobacterium sp. and the role of conserved or nonconserved residues on its catalytic activity”, (2007. 03), Applied Microbiology and Biotechnology. 74, 791-804.
    • Kye Man Cho, Su Young Hong, Sun Mi Lee, Yong Hee Kim, Goon Gjung Kahng, Hoon Kim, and Han Dae Yun. “A cel44C-man26A gene of endophytic Paenibacillus polymyxa GS01 has multi-glycosyl hydrolases in two catalytic domains”, (2006. 11), Applied Microbiology and Biotechnology. 73, 618-630.
    • Takuji Oka, Yuka Sameshima, Tomoko Koga, Hoon Kim, Masatoshi Goto, and Kensuke Furukawa. “Protein O-mannosyltransferase A of Aspergillus awamori is involved in O-mannosylation of glucoamylase I”, (2005. 11. 04), Microbiology-SGM. 151, 3657-3667.
    • Thangaswamy Selvaraj, Padmanabhan Chellappan, Yu Jin Jeong, and Hoon Kim. “Occurrence and quantification of vesicular-arbuscular mycorrhizal (VAM) fungi in industrial polluted soils”, (2005. 2), Journal of Microbiology and Biotechnology. 15(1), 147-154.
    • Mi-Jeong Yang, Sun-Hwa Jung, Eun-Sun Shin, Jungho Kim, Han Dae Yun, Sui-Lam Wong, and Hoon Kim. “ex-pression of a Bacillus subtilis endoglucanase in protease-deficient Bacillus subtilis strains”, (2004), Journal of Microbiology and Biotechnology. 14(2), 430-434.
    • Eun-Sun Shin, Mi-Jeong Yang, Kyung Hwa Jung, Eun-Ju Kwon, Jae Sung Jung, Seur Kee Park, Jungho Kim, Han Dae Yun, and Hoon Kim. “Influence of the transposition of the thermostabilizing domain of Clostridium thermocellum Xylanase (XynX) on xylan-binding and thermostabilization”, (2002), Applied and Environmental Microbiology. 68(7), 3496-3501.
    • Hoon Kim, Joong-Hoon Ahn, Jenifer M. Gorlach, Claudio Caprari, John S. Scott-Craig, and Jonathan D. Walton. “Mutational analysis of two-β-glucanase genes from the plant pathogenic fungus Cochliobolus carbonum”, (2001), Molecular Plant-Microbe Interactions. 14, 1436-1443.
    • Hoon Kim, K. H. Jung, and M. Y. Pack. “Molecular characterization of xynX, a gene encoding a multidomain xylanase with a thermostabilizing domain from Clostridium thermocellum”, (2000) Applied Microbiology and Biotechnology. 54, 521-527.
    • Hoon Kim, He-sug Ju, and Jungho Kim. “Characterization of an extracellular poly(3-hydroxy-5-phenylvalerate) depolymerase from Xanthomonas sp. JS02”, (2000), Applied Microbiology and Biotechnology. 53, 323-327.
    • Hoon Kim, Masatoshi Goto, Heo-Jin Jeong, Kyung Hwa Jung, Il Kwon, and Kensuke Furukawa. “Functional analysis of a hybrid endoglucanase of bacterial origin having a cellulose-binding domain of fungal exoglucanase”, (1998), Applied Biochemistry and Biotechnology. 75(2-3), 193-204.
    • Hoon Kim, Sergey O. Sablin, and Rona R. Ramsay. “Inhibition of monoamine oxidase A by β-carboline derivatives”, (1997), Archives Biochemistry and Biophysics. 337 (1), 137-142.
    • Dong Ho Ahn, Hoon Kim, and M. Y. Pack. "Cleavage of Bacillus subtilis endo-β-1,4-glucanase by B. megaterium protease", Biotechnol. Lett. (1993), 15 (2), 127-132.
    • Hoon Kim, Sungmin F. Kim, and M. Y. Pack. "C-Terminal Processing of Bacillus subtilis BSE616 Endo-β-1,4-glucanase in Bacillus megaterium", Biotechnol. Lett. (1991), 13(11), 799-804.
    • Hoon Kim, and M. Y. Pack. "Endo-β-1,4-glucanase Encoded by Bacillus subtilis Gene Cloned in Bacillus megaterium", Enzyme and Microbial Technology, (1988), 10, 347-351.
  • 문철 교수 (Moon, Cheol)

    문철교수 (Moon, Cheol)

    전공
    약제학
    강의과목
    약제학, 약물송달학 의약품제조및품질관리학
    전화번호
    061) 750-3758
    이메일
    cheolm@scnu.ac.kr

    학력

    • 학 사 : 서울대학교
    • 석 사 : 서울대학교
    • 박 사 : University of Michigan, Ann Arbor (2007)

    주요경력

    • LG화학 기술연구원 바이오텍연구소 연구원
    • University of Michigan, Ann Arbor 박사 후 연구원
    • NAL Pharmaceuticals, Manager, Technology Development

    논문

    • P. Maharjan, K.H. Cho, A. Maharjan, M.C. Shin, C. Moon, and K.A. Min. “Pharmaceutical challenges and perspectives in developing ophthalmic drug formulations.” J. Pharm. Investigation. 49: 215-228, 2019
    • E. Oh, U. Kim, B.J. Lee, and C. Moon. “Multivariate Statistical Optimization of Tablet Formulations Incorporating High Doses of a Dry Herbal Extract.” Pharmaceutics, 11: 79. 2019
    • T. Park, K.A. Min, H. Cheong, C. Moon, and M.C. Shin. “Genetic engineering and characterisation of chlorotoxin-fused gelonin for enhanced glioblastoma therapy.” J Drug Targeting, e-Published. 2018
    • H. Song, C. Moon, B.J. Lee, and E. Oh. “Mesoporous Pravastatin Solid Dispersion Granules Incorporable Into Orally Disintegrating Tablets.” J Pharm Sci. 107: 1886-1895, 2018
    • T. V. Nguyen, M. C. Shin, K. A. Min, Y. Huang. E. Oh and C. Moon. “Cell-penetrating peptide-based non-invasive topical delivery systems.” J. Pharm. Investigation. 48: 77-87, 2018
    • H. Wang, C. Moon, M.C.Shin,, Y. Wang, H. He, V.C. Yang, and Y. Huang. “Heparin-regulated prodrug-type macromolecular theranostic systems for cancer therapy.” Nanotheranostics. 1: 114-130, 2017
    • M. C. Shin, K. A. Min, H. Cheong, C. Moon, Y. Huang, H. He, and V. C. Yang. “Tandem-multimeric F3-gelonin fusion toxins for enhanced anti-cancer activity for prostate cancer treatment.” Int J Pharm. 524: 101-110, 2017
    • C. Moon and E. Oh. "Rationale and strategies for formulation development of oral fixed dose combination drug products." J. Pharm. Investigation. 46: 615-631, 2016
    • S. Kim, B. Gupta, C. Moon, E. Oh, J. Jeong, C. S. Yong, and J. O. Kim. "Employing an optimized spray-drying process to produce ezetimibe tablets with an improved dissolution profile” J. Pharm. Investigation. 46: 583-592, 2016
    • T. Lin, E. Liu, H. He, M. C. Shin, C. Moon, V. C. Yang, and Y. Huang. “Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides”. Acta Pharm. Sin. B. 6: 352-358, 2016
    • M. C. Shin, K. A. Min, H. Cheong, C. Moon, Y. Huang, H. He, and V. C. Yang. “Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity” Pharm. Res. 33: 2218-2228, 2016
    • D. J. Jang, C. Moon, E. Oh, Improved tumor targeting and antitumor activity of camptothecin loaded solid lipid nanoparticles by preinjection of blank solid lipid nanoparticles. Biomed Pharmacother. 80:162-172, 2016
    • D. H. Truong, T. H. Tran, T. Ramasamy, J. Y. Choi, H. H. Lee, C. Moon, H. G. Choi, C. S. Yong, and J. O. Kim. “Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib.” AAPS PharmSciTech 17: 466-473, 2016
    • Y. Yang, S. Y. Park, T. T. Nguyen, Y. H. Yu, T. V. Nguyen, E. G. Sun, J. Udeni, M. H. Jeong, I. Pereira, C. Moon, H. H. Ha, K. K. Kim, J. S. Hur, H. Kim, “Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility.” PLoS One. 10: e0137889, 2015
    • J. Tan, H. Cheong, Y. S. Park, H. Kim, M. Zhang, C. Moon*, and Y. Huang*. “Cell-penetrating peptide-mediated topical delivery of biomacromolecular drugs.” Curr Pharm Biotechnol. 15:231-239, 2014
    • M. C. Shin, J. Zhang, K. A. Min, K. Lee, C. Moon, J. P Balthasar, and V. C. Yang. “Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy.” J Control Release. 194:197-210, 2014
    • T. T. Nguyen, S. Yoon, Y. Yang, H. B. Lee, S. Oh, M. H. Jeong, J. J. Kim, S. T. Yee, F. Crişan, C. Moon, K. Y. Lee, K. K. Kim, J. S. Hur, and H. Kim, “Lichen secondary metabolites in Flavocetraria cucullata exhibit anti-cancer effects on human cancer cells through the induction of apoptosis and suppression of tumorigenic potentials.” PLoS One. 9: e111575, 2014
    • K. H. Kim, S. A. Cho, J. Y. Lim, C. Moon, and S. H. Jeong “Preparation of microcapsules with the evaluation of physicochemical properties and molecular interaction” Arch. Pharm. Res. 37: 1570-1577, 2014
    • D. H. Truong, T. H. Tran, T. Ramasamy, J. Y. Choi, H. H. Lee, C. Moon, H. G. Choi, C. S. Yong, and J. O. Kim. "Development of Solid Self-Emulsifying Formulation for Improving h4e Oral Bioavailability of Erlotinib." AAPS PharmSciTech. E-published (2015-8-4)
    • J. Tan, H. Cheong, Y. S. Park, H. Kim, M. Zhang, C. Moon, and Y. Huang. "Cell-penetrating peptide-mediated topical delivery of biomacromolecular drugs." Curr Pharm Biotechnol. 15:231-239, 2014
    • M. C. Shin, J. Zhang,,K. A. Min, K. Lee, C. Moon, J. P Balh4asar, and V. C. Yang. "Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer h4erapy." J Control Release. 194:197-210, 2014
    • K. H. Kim, S. A. Cho, J. Y. Lim, C. Moon, and S. H. Jeong "Preparation of microcapsules wih4 h4e evaluation of physicochemical properties and molecular interaction" Arch. Pharm. Res. 37: 1570-1577, 2014
    • A. E. David, J. Gong, B. Chertok, R.C. Domszy, C. Moon, Y. S. Park, N. S. Wang, A. J. Yang, and V. C. Yang, "Immobilized h4ermolysin for highly efficient production of low molecular weight protamine - an attractive cell - penetrating peptide for macromolecular drug delivery applications. "J. Biomed. Mater. Res. A. 100A: 211-219, 2012
    • R. K. Subedi, J. P. Ryoo, C. Moon, and H. K. Choi, "Influence of formulation variables in transdermal drug delivery system containing zolmitriptan" Int. J. Pharm. 419:209-214, 2011
    • Y. Huang, Y. S. Park, C. Moon, A. E. David, H. S. Chung, and V. C. Yang, "Synh4etic skin-permeable antigens enabling transcutaneous immunization" Angew. Chem. Int. Ed. 49:2724-2727, 2010
    • Y. M. Kwon, H. S. Chung, C. Moon, J. Yockman, Y. J. Park, S. D. Gitlin, A. E. David, and V. C. Yang, "L-Asparaginase encapsulated intact eryh4rocytes for treatment of acute lymphoblastic leukemia (ALL)" J. Controlled Release 139(3):182-189, 2009
    • C. Moon, Y. M. Kwon, W. K. Lee, Y. J. Park, L. C. Chang, and V. C. Yang, "A novel polyrotaxane-based intracellular delivery system for camptoh4ecin: In vitro feasibility evaluation" J. Biomed. Mater. Res A. 84: 238-246, 2008
    • C. Moon, Y. M. Kwon, W. K. Lee, Y. J. Park, and V. C. Yang, "In vitro assessment of a novel polyrotaxane-based drug delivery system integrated wih4 a cell-penetrating peptide." J. Control. Release 124:43-50, 2007
    • Y. J. Park, L. C. Chang, J. F. Liang, C. Moon, C. P. Chung, and V. C. Yang, "Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: in vitro and in vivo study." FASEBJ. 19(11):1555-1557, 2005

    특허

    • E. Oh, C. Moon, and V.T. Nguyen, “Once-daily fixed-dose combination bilayer tablet comprising cilostazol and angiotensin receptor blockers and manufacturing method.” Patent No. KR101920309B1 (18-11-14)
    • E. Oh, D.Q. Nguyen, and C. Moon, “Once-daily fixed-dose combination capsule formulations comprising sustained release cilostazol and immediate release statin minitablets and preparation method thereof.” Patent No. KR101920307B1 (18-11-14)
    • E. Oh, D.Q. Nguyen, and C. Moon, “Formulation composition of once-daily fixed-dose combination bilayer tablets of cilostazol and clopidogrel and manufacturing method thereof.” Patent No. KR101843396B1 (18-03-23)
  • 박애경 교수 (Park, Ae Kyung)

    박애경교수 (Park, Ae Kyung)

    전공
    보건학(보건통계)
    연구분야: Bioinformatics & Biostatistics in cancer genomics & epigenomics
    강의과목
    예방약학, 약학통계, 의약품정보학
    전화번호
    061) 750-3757
    이메일
    parkak11@scnu.ac.kr

    학력

    • 학사 : 서울대학교 약학대학 
    • 석사 : 서울대학교 약학대학 (생화학전공) 
    • 박사 : 서울대학교 보건대학원 (보건통계전공) 

    주요경력

    • 한국과학기술원(KIST) 연구원 (1991)
    • 신성대학교 전임강사/조교수 (1998-2005)
    • 서울대학교 의과대학 박사후연구원 (2009-2011)
    • 순천대학교 약학대학 조교수 (2011-2015)

    논문

    1) SCI(SCIE) 논문
    • Moon HG, Oh K, Lee J, Lee M, Kim JY, Yoo TK, Seo MW, Park AK, Ryu HS, Jung EJ, Kim N, Jeong S, Han W, Lee DS, Noh DY. Prognostic and functional importance of h4e engraftment-associated genes in h4e patient-derived xenograft models of triple-negative breast cancers. Breast Cancer Res Treat. 2015 Oct 5.
    • Lee JY, Moon YJ, Lee HO, Park AK, Choi SA, Wang KC, Han JW, Joung JG, Kang HS, Kim JE, Phi JH, Park WY, Kim SK. Deregulation of Retinaldehyde Dehydrogenase 2 Leads to Defective Angiogenic Function of Endoh4elial Colony-Forming Cells in Pediatric Moyamoya Disease. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1670-7.
    • Lee SW, Kim M, Kim H, Han SS, Lee H, Lee JP, Kim DK, Lim CS, Kim YS, Park AK, Joo KW. Obesity modifies h4e association between serum 25-hydroxyvitamin D and insulin resistance in Korean general population wih4out increased fasting glucose levels. Tohoku J Exp Med. 2014;234(2):89-97
    • Sung HY, Park AK, Ju W, Ahn JH. Overex-pression of mucin 13 due to promoter meh4ylation promotes aggressive behavior in ovarian cancer cells. Yonsei Med J. 2014 Sep;55(5):1206-13
    • Sung HY, Choi EN, Lyu D, Park AK, Ju W, Ahn JH. Aberrant hypomeh4ylation-mediated AGR2 overex-pression induces an aggressive phenotype in ovarian cancer cells. Oncol Rep. 2014 Aug;32(2):815-20.
    • Hong CE, Park AK, Lyu SY. Synergistic anticancer effects of lectin and doxorubicin in breast cancer cells. Mol Cell Biochem. 2014 Sep;394(1-2):225-35
    • Lee JY, Park AK, Lee ES, Park WY, Park SH, Choi JW, Phi JH, Wang KC, Kim SK. miRNA ex-pression analysis in cortical dysplasia: regulation of mTOR and LIS1 pah4way. Epilepsy Res. 2014 Mar;108(3):433-41
    • Kang HS, Moon YJ, Kim YY, Park WY, Park AK, Wang KC, Kim JE, Phi JH, Lee JY, Kim SK. Smooh4-muscle progenitor cells isolated from patients wih4 moyamoya disease: novel experimental cell model. J Neurosurg. 2014 Feb;120(2):415-25
    • Jeon S, Han S, Lee K, Choi J, Park SK, Park AK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Kim H, Ahn Y, Kang D. Genetic variants of AICDA/CASP14 associated wih4 childhood brain tumor. Genet Mol Res. 2013 Jun 20;12(2):2024-31
    • Takwi AA, Li Y, Becker Buscaglia LE, Zhang J, Choudhury S, Park AK, Liu M, Young KH, Park WY, Martin RC, Li Y. A statin-regulated microRNA represses human c-Myc ex-pression and function. EMBO Mol Med. 2012 Sep;4(9):896-909
    • Han S, Koo HH, Lan Q, Lee KM, Park AK, Park SK, Sung H, Ahn HS, Shin HY, Kang HJ, Seo JJ, Ahn YO, Kim H, Roh4man N, Kang D. Common variation in genes related to immune response and risk of childhood leukemia. Hum Immunol. 2012 Mar;73(3):316-9
    • Park AK, Lee SJ, Phi JH, Wang KC, Kim DG, Cho BK, Haberler C, Fattet S, Dufour C, Puget S, Sainte-Rose C, Bourdeaut F, Grill J, Delattre O, Kim SK, Park WY. Prognostic classification of pediatric medulloblastoma based on chromosome 17p loss, ex-pression of MYCC and MYCN, and Wnt pah4way activation. Neuro Oncol. 2012 Feb;14(2):203-14.
    • Oh K, Ko E, Kim HS, Park AK, Moon HG, Noh DY, Lee DS. Transglutaminase 2 facilitates h4e distant hematogenous metastasis of breast cancer by modulating interleukin-6 in cancer cells. Breast Cancer Res. 2011 Oct 3;13(5):R96.
    • Arora H, Qureshi R, Park AK, Park WY. Coordinated regulation of ATF2 by miR-26b in γ-irradiated lung cancer cells. PLoS One. 2011;6(8):e23802
    • Arora H, Qureshi R, Jin S, Park AK, Park WY. miR-9 and let-7g enhance h4e sensitivity to ionizing radiation by suppression of NFκB1. Exp Mol Med. 2011 May 31;43(5):298-304
    • Jin X, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, Kang BG, Beck S, Lee SJ, Kim JK, Park AK, Park WY, Choi YJ, Nam DH, Kim H. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res. 2011 Apr 15;71(8):3066-75.
    • Lim YH, Park AK, Kim H. Modifiers of diurnal temperature range and mortality association in six Korean cities. Int J Biometeorol. 2012 Jan;56(1):33-42.
    • Park AK, Hong YC, Kim H. Effect of changes in season and temperature on mortality associated wih4 air pollution in Seoul, Korea. J Epidemiol Community Healh4. 2011 Apr;65(4):368-75.
    • Park AK, Kim H, Jin HJ. Phylogenetic analysis of rRNA meh4yltransferases, Erm and KsgA, as related to antibiotic resistance. FEMS Microbiol Lett. 2010 Aug 1;309(2):151-62
    • Kim EH, Park AK, Dong SM, Ahn JH, Park WY. Global analysis of CpG meh4ylation reveals epigenetic control of h4e radiosensitivity in lung cancer cell lines. Oncogene. 2010 Aug 19;29(33):4725-31
    • Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Roh4man N, Kang D. Polymorphisms in innate immunity genes and risk of childhood leukemia. Hum Immunol. 2010 Jul;71(7):727-30
    • Han W, Kang SY, Kang D, Park SK, Lee JY, Kim H, Park AK, Noh DY. Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk. Oncol Rep. 2010 Mar;23(3):763-9
    • Lee JY, Park AK, Lee KM, Park SK, Han S, Han W, Noh DY, Yoo KY, Kim H, Chanock SJ, Roh4man N, Kang D. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. Carcinogenesis. 2009 Sep;30(9):1528-31
    • Park AK, Kim H, Jin HJ. Comprehensive phylogenetic analysis of evolutionarily conserved rRNA adenine dimeh4yltransferase suggests diverse bacterial contributions to h4e nucleus-encoded plastid proteome. Mol Phylogenet Evol. 2009 Feb;50(2):282-9
    2) 국내논문
    • 박애경, 김호. 유전체 연관 연구에서의 검정력 및 연구대상수 계산 고찰. 대한예방의학회지(J Prev Med Public Healh4). 2007 Mar;40(2):114-21
  • 백만정 교수 (Paik, Man-Jeong)

    백만정교수 (Paik, Man-Jeong)

    전공
    약품분석학
    강의과목
    약품분석학, 기기분석학, 임상의학분석학, 법과학분석
    전화번호
    061) 750-3762
    이메일
    paik815@scnu.ac.kr

    학력

    • 학 사 : 수원대학교
    • 석 사 : 성균관대학교
    • 박 사 : 성균관대학교

    주요경력

    • 서울의과학연구소 유전성대사질환연구팀 연구원 및 팀장 (1997.2-2000.12)
    • 성균관대학교 경기의약연구센터 선임연구원 (2002.10-2003.4).
    • 성균관대학교 약학대학 연구부교수 (2004.8-2006.8)
    • 아주대학교 의과대학 신경재생줄기세포연구소 연구부교수 (2006.9-2010.8)
    • 아주대학병원 유전질환전문센터 참여교수 (2007.1-2012.2)
    • 아주대학교 BK21 분자과학기술사업단 참여교수 (2008.9-2010.8)
    • 교육과학기술부 국가기술수준평가 전문위원 (2010.5-2010.7)
    • 아주대학교 분자과학기술학과 연구교수 (2010.8-2012.2)
    • ㈜한국의약연구소 생물학적동등성시험 심사위원 (2010.11-2013.2)
    • ㈜바이오토피아 미생물대사 연구 자문위원 (2011.9-2013.2)
    • 한국유전학연구소-김숙자 소아청소년병원 연구자문위원 (2015.9-2018.8)
    • 국립환경과학원-환경시험 검사기관 정도관리 기술위원회 위원 (2015.7-현재)
    • 기초연구실지원사업-환경성호흡기질환 통합오믹스연구실 단장 (2015.9-현재)
    • 순천대학교 생명약학연구소 연구소장 (2017.3-2019.2)
    • 순천대학교 약학대학 조교수, 부교수, 학과장 (2012.2-현재)

    논문

    • Lee H-S, Seo C, Hwang Y-H, Shin T-H, Park H-J, Kim Y, Ji M, Min J, Choi S, Kim H, Park A-K, Yee S-T, Lee G, Paik M-J (2019) Metabolomic approaches to polyamines including acetylated derivatives in lung tissue of mice with asthma. Metabolomics. 15(8) 1-9. (교신저자)
    • Shin T-H, Seo C, Lee D-Y, Ji M, Manavalan B, Basith S, Chakkarapani S-K, Kang S-H, Lee G, Paik M-J, Park C-B (2019) Silica-coated magnetic nanoparticles induce glucose metabolic dysfunction in vitro via the generation of reactive oxygen species. Archives of Toxicology. 1-12. (공동교신저자)
    • Kim H-A, Lee H-S, Shin T-H, Jung J-Y, Baek W-Y, Park H-J, G Lee, Paik M-J, Suh C-H (2018) Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever. Lupus (2018) 27, 930–938. (공동교신저자)
    • Seo C, Na M, Jang J, Park M, Choi B, Lee S, Paik M-J (2018) Monitoring of altered amino acid metabolic pattern in rat urine following intraperitoneal injection with γ-hydroxybutyric acid. Metabolomics. 14(111) 1-8. (공동교신저자)
    • Seo C, Hwang Y-H, Lee H-S, Kim Y, Shin T-H, Lee G, Son Y-J, Kim H, Yee S-T, Park A-K, Paik M-J (2017) Metabolomic study for monitoring of biomarkers in mouse plasma with asthma by gas chromatography-mass spectrometry. Journal of Chromatography B. 1063, 156-162. (공동교신저자)
    • Seo C, Park M, Choi B, Lee S, Paik M-J (2016) Metabolomic analysis of urinary organic acids following intraperitoneal injection with γ-hydroxybutyric acid in rats. Metabolomics. 12 (190) 1-9. (공동교신저자)
    • Shin T-H, Phukan G, Shim J-S, Nguyen D-T, Kim Y, Oh-Lee J-D, Lee H-S, Paik M-J, Lee G (2016) Restoration of Polyamine Metabolic Patterns in In Vivo and In Vitro Model of Ischemic Stroke following Human Mesenchymal Stem Cell Treatment. Stem Cells International. 2016, 1-11. (공동교신저자)
    • Seo C, Hwang Y-H, Kim Y, Joo B-S, Yee S-T, Kim C-M, Paik M-J (2016) Metabolomic study of aging in mouse plasma by gas chromatography-mass spectrometry. Journal of Chromatography B. 1025, 1-6. (공동교신저자)
    • Paik M-J, Kim H-S, Lee Y-S, Choi H-D, Pack J-K, Kim N, Ahn Y-H (2016) Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal. Amino Acids. 48 (1), 213-217. (공동교신저자)
    • Hur H, Paik M-J, Xuan Y, Nguyen D-T, Ham I-H, Yun J, Cho Y-K, Lee G, Han S-U (2014) Quantitative measurement of organic acids in tissues from gastric cancer patients indicates increased glucose metabolism in gastric cancer. PLOS one, 9, 1-9. (공동 제1저자)
    • Paik M-J, Kim D-K, Nguyen D-T, Lee G, Rhee C-S, Yoon I-Y, Kim J-W (2014) Correlation of daytime sleepiness with urine metabolites in patients with obstructive sleep apnea. 18(3) 517-523. (공동교신저자)
    • Paik M-J, Kang J-S, Huang B-S, Carey J-R, Lee W (2013) Development and application of chiral crown ethers as selectors for chiral separation in high-performance liquid chromatography and nuclear magnetic resonance spectroscopy. Journal of Chromatography A. 1274, 1-5. (제1저자)
    • Shim W-Y, Paik M-J, Nguyen D-T, Lee J-K, Lee Y, Ho Kim J-H, Shin E-H, Kang J-S, Jung H-S, Choi S, Park S, Shim J-S, Lee G (2012) Analysis of changes in gene ex-pression and metabolic profiles induced by silica-coated magnetic nanoparticles. ACS Nano, 6(9), 7665-7680. (공동 제1저자)
    • Paik M-J, Kim H-S, Lee Y-S, Choi H-D, Pack J-K, Kim N, Ahn Y-H (2015) Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal. Amino Acids. In press
    • Seo C, Yoon J, Rhee Y, Kim J-J, Name S-J, Lee W, Lee G, Yee S-T, Paik M-J (2015) Simultaneous analysis of seven 2-hydroxy fatty acids as tert-butyldimeh4ylsilyl derivatives in plasma by gas chromatography-mass spectrometry Biomedical Chromatography, 29, 156-160.
    • Hur H, Paik M-J, Xuan Y, Nguyen D-T, Ham I-H, Yun J, Cho Y-K, Lee G, Han S-U (2014) Quantitative measurement of organic acids in tissues from gastric cancer patients indicates increased glucose metabolism in gastric cancer. PLOS one, 9, 1-9.
    • Paik M-J, Kim D-K, Nguyen D-T, Lee G, Rhee C-S, Yoon I-Y, Kim J-W (2014) Correlation of daytime sleepiness wih4 urine metabolites in patients wih4 obstructive sleep apnea. Sleep Breah4, 18, 517-523.
    • Paik M-J, Kang J-S, Huang B-S, Carey J-R, Lee W (2013) Development and application of chiral crown eh4ers as selectors for chiral separation in high-performance liquid chromatography and nuclear magnetic resonance spectroscopy. Journal of Chromatography A. 1274, 1-5.
    • Nguyen D-T, Lee G, Paik M-J (2013) Keto acid profiling analysis as eh4oxime/tert-butyldimeh4ylsilyl derivatives by gas chromatography-mass spectrometry. Journal of Chromatography B, 913-914, 48-54.
    • Shim W-Y+, Paik M-J+, Nguyen D-T, Lee J-K, Lee Y, Ho Kim J-H, Shin E-H, Kang J-S, Jung H-S, Choi S, Park S, Shim J-S, Lee G (2012) Analysis of changes in gene ex-pression and metabolic profiles induced by silica-coated magnetic nanoparticles. ACS Nano, 6(9), 7665-7680
    • Nguyen D-T, Kim K-R, Lee G, and M-J Paik (2012) Chiral separation of N-meh4yl-DL-aspartic acid in rat brain tissue as N-eh4oxycarbonylated (S)-(+)-2-octylesterderivatives by GC-MS, Biomedical Chromatography, in press.
    • Paik M-J, Shin J-Y, Lee G, and Ahn Y-H (2011)Monitoring of altered free fatty acid metabolic patterns in rat plasma following hemorrhagic stroke. Analytical Letters, 44, 1323-1332.
    • Yu J, Han K-S. Lee G, Paik M-J, and Kim K-R (2010) Enantiomeric composition analysis of pranoprofen in equine plasma and urine by chiral liquid chromatography-tandem mass spectrometry in selected reaction monitoring mode, Journal of Chromatography B, 878, 3249-3254.
    • Paik M-J, Ahn Y-H, Lee P-H, Kang H, Park C-B, Choi S, and Lee G (2010) Polyamine Patterns in h4e cerebrospinal fluid of patients wih4 Parkinson's disease and multiple system atrophy, Clinica Chimica Acta, 41, 1532-1535.
    • Kim J-W, Lee G, Moon S-M, Park M-J, Hong S-K, Ahn Y-H, Kim K-R, and Paik M-J(2010) Metabolomic screening and star pattern recognition by urinary amino acid profile analysis from bladder cancer patients, Metabolomics, 6, 202-206.
    • Paik M-J, Kim H, Lee J, Brand J, and Kim K-R (2009) Separation of triacylglycerols and free fatty acids in microalgal lipids by solid-phase extraction for separate fatty acid profiling analysis by gas chromatography, Journal of Chromatography A, 1216, 5917-5923.
    • Paik M-J, Kuon D, Cho J, and Kim K-R (2009) Altered urinary polyamine patterns of cancer patients under acupuncture h4erapy, Amino Acids, 37, 407-413.
    • Paik M-J, Li W-Y, Ahn Y-H, Lee P-H, Choi S, Kim K-R, Kim Y-M, Bang O-Y, and Lee G (2009) The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats, Clinica Chimica Acta, 402, 25-30.
    • Yu J, Lee G, Jeong Y, Ahn Y-H, Hu M-B, Kim S-J, Kim K-R, and Paik M-J (2009) Enantiomeric Composition tests of ketoprofen in equine plasma and urine as diastereomeric (S)-(-)-1-phenyleh4ylamides by achiral GC-MS, Chromatographia, 69, 59-63.
    • Paik M-J, Lee J, and Kim K-R (2008) N-Eh4oxycarbony-lation combined wih4 (S)-1- phenyleh4ylamidation for enantioseparation of amino acids by achiral gas chromato-graphy and gas chromatography–mass spectrometry, Journal of Chromatography A, 1214, 151–156.
  • 백수희 교수 (Paik, Soo-Heui)

    백수희교수 (Paik, Soo-Heui)

    전공
    임상약학
    강의과목
    약물치료학, 약물동태학, 의약품행정학
    전화번호
    061) 750-3766
    이메일
    shwhite@scnu.ac.kr

    학력

    • 학 사 : 서울대학교
    • 석 사 : 숙명여자대학교
    • 박 사 : 성균관대학교

    주요경력

    • 서울대학교병원 인턴 약사
    • 서울대학교병원 임상의학연구소 임상연구약사
    • 서울대학교병원 약제부 조제과, 소아조제과, 주사조제계 주임약사
    • ㈜ 한국얀센 메디칼부
    • 보령제약㈜ 중앙연구소 수석연구원

    논문

    • Ghim J.-L., Paik S.H., Md. Hasanuzzaman, Chi Y.H., Choi H.G., Kim D.-H. Shin J.-G. 2015. Absolute Bioavailability and Pharmacokinetics of h4e Angiotensin II Receptor Antagonist Fimasartan in Healh4y subjects. J. Clin. Pharmacol. DOI: 10.1002/jcph.618.
    • Kim T.H., Shin S., Landersdorfer C.B., Chi Y.H., Paik S.H., Myung J., Yadav R., Horkovics-Kovats S., Bulitta J.B., Shin B.S. 2015. Population Pharmacokinetic Modeling of h4e Enterohepatic Recirculation of Fimasartan in Rat, Dog and Human. AAPS Journal 17(5), 1210-1223.
    • Kim T.H., Kim M.K., Kim M.G., Shin B.S., Kim K.-B., Lee J.B., Paik S.H., Yoo S.D. 2015. Simultaneous determination of phenoxyeh4anol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS wih4 polarity switching: application to ADME studies. Talanta 144, 29-38.
    • Lee J.-Y., Choi Y.J., Oh S.J., Chi Y.H., Paik S.H., Lee K.H., Jung J.-K., Ryu C.S., Kim K.-B., Kim D.-H., Yoon Y.-R., Kim S.K. 2015. Characterization of fimasartan metabolites in human liver microsomes and human plasma. Xenobiotica, Published online: 11 Jun 2015. DOI:10.3109/00498254.2015.1047429
    • Jeong E.-S., Kim Y.-W., Kim H.-J., Shin H.-J., Shin J.-G., Kim K.H., Chi Y.H., Paik S.H., Kim D.-H. 2015. Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3. Xenobiotica 45(1), 10-18.
    • Kim, T.H., Shin, S., Bashir, M., Chi, Y.H., Paik, S.H., Lee, J.H., Choi, H.J., Choi, J.H., Yoo, S.D., Bulitta, J.B., 2014. Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats. Xenobiotica , 1-13.
    • Chi, Y.H., Lee, J.H., Kim, J.H., Tan, H.K., Kim, S.L., Lee, J.Y., Rim, H.K., Paik, S.H., Lee, K.T., 2013. Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist. Biol. Pharm. Bull. 36(7), 1208-1215.
    • Choi, M.J., Kwon, G.H., Han, N.S., Yoo, B.W., Kim, J.H., Paik, S.H., Chi, Y.H., Lee, K., Lee, J.Y., 2013. Development of 3D-QSAR CoMSIA models for 5-(biphenyl-2-yl)-1 H-tetrazole derivatives as angiotensin II receptor type 1 (AT 1) antagonists. Bioorg. Med. Chem. Lett. 23, 4540-4546.
    • Ryu S., Shin J.-S., Cho Y.-W., Kim H.K., Paik S.H., Lee J.H., Chi Y.H., Kim J.H., Kim J.H., Lee K.-T. 2013. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synh4ase ex-pressions via nuclear factor-kappa b and activator protein-1 inactivation. Biol. Pharm. Bull. 36(3), 467-474.
    • Choi, H., Choi, J., Lee, J.Y., Kim, J.H., Kim, J.H., Lee, J.K., Kim, G.I., Park, Y., Chi, Y.H., Paik, S.H., 2013. Synh4esis and evaluation of nicotinamide derivative as anti-angiogenic agents. Bioorg. Med. Chem. Lett. 23, 2083-2088.
    • Kim, J.H., Lee, J.H., Paik, S.H., Kim, J.H., Chi, Y.H., 2012. Fimasartan, a novel angiotensin II receptor antagonist. Arch. Pharm. Res. 35, 1123-1126.
    • Choi, H., Yoo, M., Choi, J., Lee, J.Y., Kim, J.H., Kim, J.H., Lee, J.K., Kim, G.I., Park, Y., Chi, Y.H., Paik S.H., Lee J.H., Lee K.-T., 2011. BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endoh4elial cells. Bioorg. Med. Chem. Lett. 21, 6236-6241.
    • Chi, Y.H., Lee, H., Paik, S.H., Lee, J.H., Yoo, B.W., Kim, J.H., Tan, H.K., Kim, S.L., 2011. Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in h4e fasted and fed states in healh4y subjects. American Journal of Cardiovascular Drugs 11, 335-346.
    • Shin, B.S., Kim, T.H., Paik, S.H., Chi, Y.H., Lee, J.H., Tan, H.K., Choi, Y., Kim, M., Yoo, S.D., 2011. Simultaneous determination of fimasartan, a novel antihypertensive agent, and its active metabolite in rat plasma by liquid chromatography-tandem mass spectrometry. Biomedical Chromatography 25, 1208-1214.
  • 유수연 교수 (Lyu, Su-Yun)

    유수연교수 (Lyu, Su-Yun)

    전공
    천연물약품학
    강의과목
    생약학
    전화번호
    061) 750-3759
    이메일
    suyun@scnu.ac.kr

    학력

    • 학 사 : 동덕여자대학교 약학과 (2000)
    • 석 사 : 숙명여자대학교 약학과 (2003)
    • 박 사 : 영국 University of Nottingham 약학과 (2007)

    주요경력

    • 서울여자대학교 화학과 연구원
    • 독일 함부르크 대학교 교환대학원생 (한국연구재단 장학생)
    • 일본 도쿄여자의과대학 박사 후 연구원
    • 한국화학시험연구원 사업기획팀 4급
    • 대구한의대학교 한약재 약리학과 조교수 및 학과장
    • 순천대학교 약학과 조교수, 부교수

    논문

    • Chun, Y. H., Hong, C. E., and Lyu, S. Y. Anti-oxidant and anti-inflammatory effects of Ziziphus jujuba. 생약학회지 (accepted) (2019)
    • Park, J. J., Hong, C. E., and Lyu, S. Y. Anti-oxidant and anti-inflammatory effects of Viscum album coloratum. Nat. Prod. Sci. (accepted) (2019)
    • Hong, C. E., Han, S. Y., Kim, H. K., and Lyu, S. Y. Increased Th1 cytokine secretion by chiisanogenin and chiisanoside isolated from Acanthopanax chiisanensis. Yakhak Hoeji. 61, 344-349 (2017)
    • Han, S. Y., Hong, C. E., Kim, H. K., and Lyu, S. Y. Anti-cancer effects of enteric-coated polymers containing mistletoe lectin in murine melanoma cells in vitro and in vivo. Mol. Cell Biochem. 408, 73-87 (2015)
    • Hong, C. E., Park, A. K, and Lyu, S. Y. Synergistic anticancer effects of mistletoe lectin and doxorubicin in breast cancer cells. Mol. Cell Biochem. 394, 225-235 (2014)
    • Hong, C. E. and Lyu, S. Y. Evaluation of the mutagenic properties of two lignans from Acanthopanax koreanum Nakai. Toxicol. Res. 29(4), 279-283 (2013)
    • Oh, J., Hwang, I. H., Hong, C. E., Lyu, S. Y., and Na, M. K. Inhibition of fatty acid synthase by ginkgolic acids from the Leaves of Ginko biloba and their cytotoxic activity. J. Enzym. Inhib. Med. Ch. 28(3), 565-568 (2013)
    • Lyu, S. Y., Choi, J. H., Lee, H. J., Park, W. B., and Kim, G.. J. Korean mistletoe lectin promotes proliferation and invasion of trophoblast through the regulation of the Akt signaling. Reprod. Toxicol. 39, 33-39 (2013)
    • Lyu, S. Y., Shin, A. H., Hahn, D. R., and Park, W. B. Antioxidant activity of cyanidins isolated from Acanthopanax divaricatus var. albeofructus fruits in U937 macrophages. Food Sci. Biotech. 21(5), 1445-1450 (2012)
    • Choi, J. H., Lyu, S. Y., Lee, H. J., Jung, J. E., Park, W. B., and Kim, G. J. Korean mistletoe lectin regulates self-renewel of the placenta-derived mesenchymal stem cells via autophagic mechanisms. Cell Prolif. 45(5), 420-429 (2012)
    • Lyu, S. Y. and Park, W. B. Photoprotective potential of anthocyanins isolated from Acanthopanax divaricatus var. albeofructus fruits against UV irradiation in human dermal fibroblast cells. Biomol. Ther. 20(2), 201-206 (2012)
    • Hong, C. E. and Lyu, S. Y. The anti-mutagenic Effect of Mistletoe Lectin (Viscum album L. var. coloratum agglutinin). Phytother. Res. 26, 787-790 (2011)
    • Lyu, S. Y. and Park, W. B. Gene network analysis on the effect of Viscum album coloratum in T cell stimulated with anti-CD3/CD28 antibodies. Arch. Pharm. Res. 34(10), 1735-1749 (2011)
    • Hong, C. E., Cho, M. C., Jang, H. A., and Lyu, S. Y. Mutagenicity and Anti- Mutagenicity of Acanthopanax divaricatus var. albeofructus. J. Toxicol. Sci. 36(5), 661-668 (2011)
    • Hong, C. E., Ji, S. T., and Lyu, S. Y. Absence of mutagenic effects of three Nigerian medicinal plants, Bidens pilosa, Cleistopholis paterns, and Tetrapleura tetraptera. Trop. J. Pharm. Res. 10(2), 153-159 (2011)
    • Hong, C. E and Lyu, S. Y. Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes. Immune Network 11(1), 42-49 (2011)
    • Hong, C. E. and Lyu, S. Y. Genotoxicity study on five medicinal plants in Nigeria. J. Toxicol. Sci. 36(1), 87-93 (2011)
    • Lyu, S. Y. and Park, W. B. Effect of Korean mistletoe lectin on gene ex-pression profile in human T lymphocytes: A microarray study. Biomol. Ther. 18(4), 411-419 (2010)
    • Lyu, S. Y. and Park, W. B. Mistletoe Lectin Transport by M cells in Follicle Associated Epithelium (FAE) and IL-12 Secretion in Dendritic cells situated below FAE in vitro. Arch. Pharm. Res. 33(9), 1433-1441 (2010)
    • Lyu, S. Y. and Park, W. B. Modulation of IL-12 and IFN-γ Secretions by Eleutheroside E, Tortoside A, and Syringaresinol from Acanthopanax koreanum Nakai. Biomol. Ther. 18(2), 211-218 (2010)
    • Lyu, S. Y. and Park, W. B. Mistletoe lectin modulates intestinal epithelial cell-derived cytokines and B cell IgA secretion. Arch. Pharm. Res. 32(3), 443-51 (2009)
    • Lyu, S. Y., and Park, W. B. Transport of Mistletoe lectin by M cells in human intestinal follicle-associated epithelium (FAE) in vitro. Arch. Pharm. Res. 31(12), 1613-1621 (2008)
    • Lyu, S. Y., and Park, W. B. Th1/Th2 cytokine modulation in human PBMC by Acanthopanax divaricatus var. albeofructus. Food Sci. Biotech. 17(3), 631-636 (2008)
    • Lyu, S. Y., Noh, B., and Park, W. B. Modulation of Th1/Th2 cytokine secretion in human peripheral blood mononuclear cells by water extract of Acanthopanax divaricatus var. albeofructus fruits. (Yakhak Hoeji. 52(1), 27-32 (2008)
    • Lyu, S. Y., and Park, W. B. Effects of Korean Mistletoe Lectin (Viscum album coloratum) on proliferation and cytokine ex-pression in human peripheral blood mononuclear cells and T-lymphocytes. Arch. Pharm. Res. 30(10), 1252-1264 (2007)
    • Shin, A. H., Lyu, S. Y., Noh. B., Kim, J. I., Kim, O. K., and Park, W. B. Antioxidative activity of extracts of Acanthopanax divaricatus var. albeofructus leaves in human dermal fibroblast irradiated UVA. Yakhak Hoeji. 51(4), 229-234 (2007)
    • Khil, L. Y., Kim, W., Lyu, S. Y., Park, W. B., Jun, H. S., and Yoon, J. W. Mechanisms Involved in Korean Mistletoe Lectin-Induced Apoptosis of Colon Cancer Cells. World J. Gastroenterol. 13(2), 2811-2818 (2007)
    • Lyu, S. Y. and W. B. Park. Mistletoe Lectin Modulates Proliferation and Cytokine ex-pressions in Murine Splenocytes. J. Biochem. Mol. Biol. 39(6), 662-670 (2006)
    • Lyu, S. Y., Kim, J. Y., Noh, B. N., and Park, W. B. Antioxidative Activity of Water Extract of Different Parts of Acanthopanax divaricatus var. albeofructus. Yakhak Hoeji. 50(3), 191-198 (2006)
    • Lyu, S. Y., Rhim, J. Y., and Park, W. B. Antiherpetic Activities of Flavonoids against Herpes Simplex Virus Type 1 (HSV-1) and Type 2 (HSV-2) in vitro. Arch. Pharm. Res. 28(11), 1293-1301 (2005)
    • Lyu, S. Y., Moon. Y. S., and Park, W. B. Tyrosinase Inhibitory and Antioxidant Activities of Korean Mistletoe (Viscum album var. coloratum) Extract and Its Fractions. J. Food Sci. Nutr. 10(3), 244-250 (2005)
    • Lyu, S. Y., and Park, W. B. Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. Arch. Pharm. Res. 28(5), 573-581 (2005)
    • Lyu, S. Y., Kwon, Y. J., Joo, H. J., and Park, W. B. Preparation of alginate/chitosan microcapsules and enteric coated granules of mistletoe lectin. Arch. Pharm. Res. 27(1), 118-126 (2004)
    • Choi, S. H., Lyu, S. Y., and Park, W. B. Mistletoe lectin-induced apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt. Arch. Pharm. Res. 27(1), 68-76 (2004)
    • Lyu, S. Y., Moon, Y. S., Kwon, Y. J., Joo, H. J., and Park, W. B. Inhibition of porcine pancreatic elastase by Korean mistletoe (Viscum album var. coloratum) fractions. Nat. Prod. Sci. 9(4), 278-285 (2003)
    • Lyu, S. Y., Rhim, J. Y., Moon, Y. S., Jung, S. H., Lee, K. Y., and Park, W. B. Antitumor activities of extract of Viscum album var. coloratum modified with Viscum album var. coloratum agglutinin. Nat. Prod. Sci. 8(4), 155-161 (2002)
    • Rhim, J. Y., Moon, Y. S., Jung, S. H., Lee, K. Y., Lyu, S. Y., Shim, C. H., and Park, W. B. Antimicrobial activities of combined extract of Aloe vera with propolis against oral pathogens. J. Korean Soc. Food Sci. Nutr. 31(5), 899-904 (2002)
    • Lyu, S. Y., Rhim, J. Y., Park, Y. H., Suh, K. B., and Park, W. B. Changes of lectin activity of kidney beans by heating and fermentation. . J. Korean Soc. Food Sci. Nutr. 31(1), 1-6 (2002)
    • Lyu, S. Y., Choi, S. H., and Park, W. B. Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch. Pharm. Res. 25(1), 93-101 (2002)
    • Park, W. B., Lyu, S. Y., Kim, J. H., Choi, S. H., Chung, H. K., Ahn, S. H., Hong, S. Y., Yoon, T. J., and Choi, M. J. Inhibition of tumor growth and metastasis by Korean mistletoe lectin is associated with apoptosis and antiangiogenesis. Cancer. Biother. Radio. 16(5), 439-447 (2001)
    • Lyu, S. Y., Park, W. B., Choi, K. H., and Kim, W. H. Involvement of caspase-3 in apoptosis induced by Viscum album var. coloratum agglutinin in HL-60 cells. Biosci. Biotech. Biochem. 65(3), 534-541 (2001)
    • Lyu, S. Y., Park, S. M., Choung, B. Y., and Park, W. B. Comparative study of Korean (Viscum album var. coloratum) and European mistletoes (Viscum album). Arch. Pharm. Res. 23(6), 592-598 (2000)
    • Park, W. B., Choung, B. Y., Park, S. M., Kim, H. S., and Lyu, S. Y. Effects of drying process of mistletoes on cytotoxicities against cultures HL-60 and Molt-4 cells. Food Sci. and Biotechnol. 8(6), 391-396 (1999)
  • 이민아 교수 (Mina Lee)

    이민아교수 (Mina Lee)

    전공
    천연물화학
    강의과목
    천연물약품학, 한약학
    전화번호
    061) 750-3764
    이메일
    minalee@scnu.ac.kr

    학력

    • 학 사 : 경희대학교
    • 석 사 : 서울대학교
    • 박 사 : 서울대학교

    주요경력

    • 서울대학교 종합약학연구소 Post-Doc
    • 서울대학교 약학대학 연수연구원

    논문

    • Sung SH, Lee M. Anti-adipogenic activity of a new cyclic diarylheptanoid isolated from Alnus japonica on 3T3-L1 cells via modulation of PPARγ, C/EBPα and SREBP1c signaling. Bioorg Med Chem Lett. 2015, 25(20):4648-51.
    • Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ. Kuwanon v inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. PLoS One. 2015, 10(2):e0118188.
    • Isolation and structure elucidation of (-)-idescarparide, a new spiro compound from Idesia polycarpa. Tetrahedron Letters. 2014 55:5447-5449.
    • Lee M, Kim DH, Choi SZ, Son M, Sung SH. Analysis of Dioscorea japonica by Hydrophilic Interaction Liquid Chromatography. Anal Lett. 2014, 47:901-10
    • Lee M, Kim SH, Lee HK, Cho Y, Kang J, Sung SH. ent-Kaurane and ent-pimarane diterpenes from Siegesbeckia pubescens inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglia. Biol Pharm Bull. 2014, 37(1):152-7
    • Jeong EJ, Hwang L, Lee M, Lee KY, Ahn MJ, Sung SH. Neuroprotective biflavonoids of Chamaecyparis obtusa leaves against glutamate-induced oxidative stress in HT22 hippocampal cells. Food Chem Toxicol. 2014, 64:397-402
    • Cho N, Yang H, Lee M, Huh J, Kim HW, Kim HP, Sung SH. Neuroprotective Benzyl Benzoate Glycosides from Disporum viridescens Roots in HT22 Hippocampal Neuronal Cells. J Nat Prod. 2013, 76(12):2291-7
    • Lee M, Lee SH, Kang J, Yang H, Jeong EJ, Kim HP, Kim YC, Sung SH. Salicortin-derivatives from Salix pseudo-lasiogyne twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C/EBPα and SREBP1c dependent pah4way. Molecules, 2013, 18(9):10484-96
    • Lee M, Lee HH, Lee JK, Ye SK, Kim SH, Sung SH. Anti-adipogenic activity of compounds isolated from Idesia polycarpa on 3T3-L1 cells. Bioorg Med Chem Lett, 2013, 23(11):3170-4
    • Lee M, Song JY, Chin YW, Sung SH. Antiadipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells, Bioorg Med Chem Lett, 2013, 23(7):2069-73
    • Lee M, Park JH, Min DS, Yoo H, Park JH, Kim YC, Sung SH. Antifibrotic activity of diarylheptanoids from Betula platyphylla toward HSC-T6 Cells. Biosci Biotechnol Biochem, 2012, 76(9):1616-1620
    • Lee M, Lee MK, Kim YC, Sung SH. Antifibrotic constituents of Alnus firma on hepatic stellate cells, Bioorg Med Chem Lett, 2011, 21(10):2906-2910
    • Sung SH, Park SH, Song SY, Lee SJ, Lee HW, Kim SH, Lee MA, Yoon IS, Kim DD, Kang S, Sung JH. Epidermal regeneration by ent-16α, 17-dihydroxy-kauran-19-oic acid isolated from Siegesbeckia pubescens, Cell Prolif, 2011, 44(6):527-536
    • Lee MA, Lee HK, Kim SH, Kim YC, Sung SH. Chemical constituents of Alnus firma and h4eir inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia, Planta Med, 2010, 76(10):1007-1010
    • Kim SY, Kim HP, Yang H, Lee M, Ryu HJ, Jang YP, Sung SH, Kim YC. Antifibrotic activity of LCC, a cerebroside of Lycium chinense fruit, in bile duct-ligated rats. Nat Prod Sci 2009,15(2):101-105
  • 이성태 교수 (Yee, Sung-Tae)

    이성태교수 (Yee, Sung-Tae)

    전공
    면역학
    강의과목
    분자세포생물학, 면역학
    전화번호
    061)750-3752
    이메일
    sungtae@scnu.ac.kr

    학력

    • 학 사 : 부산대학교
    • 석 사 : 부산대학교
    • 박 사 : 동경대학교

    주요경력

    • 순천대학교 약학대학장
    • 순천대학교 약학대학 부학장, 약학과 학과장
    • 일본 국립예방위생 연구소 Post-Doc.
    • 한국과학기술원 생명공학연구소 연구원
    • 순천대학교 공동실험실습관장
    • BK21 사업단 참여교수

    논문

    • The inhibitory effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis International Journal of Endocrinology ID 132436 2015
    • Production of novel vinegar having antioxidant and anti-fatigue activities fromSalicornia herbacea L. Journal of Science Food Agric DOI 10.1002/jsfa. 2015
    • Antiosteoporosis activity of new oriental medicine preparation(Kyungokgo mixed wih4 water extract of Hovenia dulcis) on h4e ovariectomized mice EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2015
    • Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells h4rough h4e Induction of Apoptosis and Suppression of Tumorigenic Potentials PLOS ONE 2014
    • 3-deoxysilybin exerts anti-inflammatory effects by suppressing NF-κB activation in lipopolysaccharide-stimulated RAW264.7 macrophages Bioscience Biotechnology and Biochemistry 10.1080/09168451 2014
    • Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells h4rough mitochondrial apoptotic pah4way via activating h4e PI3K/Akt pah4way INTERNATIONAL JOURNAL OF ONCOLOGY 45(5) 1969-1976 2014
    • Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014
    • Enhanced dendritic cell maturation by h4e B-chain of Korean mistletoe lectin (KML-B), a novel TLR4 agonist INTERNATIONAL IMMUNOPHARMACOLOGY 21 309-319 2014
    • Simultaneous analysis of seven 2-hydroxy fatty acids as tert-butyldimeh4ylsilyl derivatives in plasma by gas chromatography-mass spectrometry Biomedical Chromatography DOI 10.1002/bcm.3251 2014
    • Immunoadjuvant efficacy of N-carboxymeh4yl chitosan for vaccination via dendritic cell activation Journal of Medicinal Food 17(2) 268-277 2014
    • Protective effects of HemoHIM on immune and hematopoietic system against gamma-irradiation Phytoh4erapy Research 28(2) 245-251 2014
    • Preventative effect of an herbal preparation(HemoHIM) on development of airway inflammation in mice via modulation of Th1/2 cells differentiation PLoS ONE 2013
    • Meh4od optimization for rapid measurement of carbohydrates in plasma by liquid chromatography tandem mass spectrometry Bulletin of h4e Korean Chemical Society 34(5) 1571-1574 2013
    • Organic acid profiling analysis in culture media of latic acid bacteria by gas chromatography-mass spectrometry Mass Spectrometry 3(3) 74-77 2012
    • Resveratrol analogue HS-1793 induces h4e modulation of tumor-derived T cells EXPERIMENTAL AND THERAPEUTIC MEDICINE 3(4) 592-598 2012
    • Jin Lee, Sung-Tae Yee, Jong-Jin Kim, Myung-Sook Choi, Eun-Young Kwon, Kwon-Il Seo, Mi-Kyung Lee. Ursolic acid ameliorates h4ymic atrophy and hyperglycemia in streptozotocin–nicotinamide-induced diabetic mice. Chemico-Biological Interactions. 188(3), 635-642 (2010).
    • S.J. Cho, J.I. Bang, X.F. Yu, Y.S. Lee, J.H. Kim, J.T. Jeon, c, S.T. Yee, I.K. Kong. Generation of a recloned transgenic cat expressing red fluorescence protein. Theriogenology. 73(7), 848-855 (2010).
    • Hae-Ran Park, Eun-Jin Ju, Sung-Kee Jo, Uhee Jung, Sung-Ho Kim and Sung-Tae Yee. Enhanced antitumor efficacy of cisplatin in combination wih4 HemoHIM in tumor-bearing mice. BMC Cancer. 9(85), (2009).
    • Jae-Yong Kim, Kyoung-Wuk Park, Kwang-Deog Moon, Mi-Kyung Lee, Jina Choi, Sung-Tae Yee, Ki-Hwan Shim, Kwon-Il Seo. Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. Food and Chemical Toxicology. 46(12), 3753-3758 (2008).
    • Jin GZ, Cho SJ, Choi EG, Lee YS, Yu XF, Choi KS, Yee ST, Jeon JT, Kim MO, Kong IK. Rat mesenchymal stem cells increase tyrosine hydroxylase ex-pression and dopamine content in ventral mesencephalic cells in vitro. Cell Biol Int. 32(11), 1433-8 (2008).
    • S. Y. Ko, I. H. Bae, S. T. Yee, S. S. Lee, D. Uuganbayar, J. I. Oh and C. J. Yang. Comparison of h4e Effect of Green Tea By-product and Green Tea Probiotics on h4e Growh4 Performance, Meat Quality, and Immune Response of Finishing Pigs. Asian-Aust. J. Anim. Sci. 21(10), 1486-1494 (2008).
    • Jang SM, Yee ST, Choi J, Choi MS, Do GM, Jeon SM, Yeo J, Kim MJ, Seo KI, Lee MK. Ursolic acid enhances h4e cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. Int Immunopharmacol. 9(1), 113-9 (2009).
    • Jin GZ, Yin XJ, Yu XF, Cho SJ, Choi EG, Lee YS, Jeon JT, Yee ST, Kong IK. neration of neuronal-like cells from umbilical cord blood-derived mesenchymal stem cells of a RFP-transgenic cloned cat. J Vet Med Sci. 70(7), 723-6 (2008).
    • Yu Mi Lee, Eun Jung Lee, Sung Tae Yee, Byung Il Kim, Eun Sang Choe and Hyun Wook Cho. In vivo and in vitro response to electrochemically anodized Ti-6Al-4V alloy. Journal of Materials Science: Materials in Medicine. 19(5), 1851-1859 (2008).
    • Kim SY, Park KW, Kim JY, Shon MY, Yee ST, Kim KH, Rhim JS, Yamada K, Seo KI. Induction of apoptosis by h4iosulfinates in primary human prostate cancer cells. Int J Oncol. 32(4), 869-75 (2008).
    • Kim SY, Park KW, Kim JY, Jeong IY, Byun MW, Park JE, Yee ST, Kim KH, Rhim JS, Yamada K, Seo KI. Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pah4ways in PC-3 human prostate cancer cells. Bioorg Med Chem Lett. 1;18(1), 199-204 (2008).
    • Toshiki Tamura, Takeshi Kunimatsu, Sung-Tae Yee, Osamu Igarashi, Masanori Utsuyama, Shin Tanaka, Shun-ichi Miyazaki, Katsuiku Hirokawa and Hideo Nariuchi. Molecular mechanism of h4e impairment in activation signal transduction in CD4+ T cells from old mice. 12(8), 1205-1215 (2000).
  • 손영진 교수 (Son, Young-Jin)

    손영진교수 (Son, Young-Jin)

    전공
    생물화학공학
    강의과목
    물리약학, 의약품제조 및 품질관리학
    전화번호
    061) 750-3755
    이메일
    sony@scnu.ac.kr

    학력

    • 학 사 : 성균관대학교
    • 석 사 : 성균관대학교
    • 박 사 : 서울대학교

    주요경력

    • 순천대학교 약학대학장
    • (사)대한약학회 부회장, 이사, 호남지부장
    • 교육부(한국교육개발원) 대학구조개혁평가 후속 점검위원
    • 순천대학교 기획부처장
    • 순천대학교 생명약학연구소장
    • 순천천연물의약소재개발연구센터 사무국장
    • 순천대학교 약학대학 조교수, 부교수, 학과장
    • 미국 NIH(NIDDK) Biotechnology Lab. Post-Doc.
    • 울산대학교 의과대학 (서울아산병원) 연구교수
    • ㈜종근당(바이오) 종합연구소 생물공학실 책임연구원(과장)

    논문

    • Lee Y, Jeong MH, Kim KJ, Baek SH, Hur JS, Son YJ. The extract of Ramalina litoralis inhibits osteoclast differentiation. Biotechnology and Bioprocess Engineering. 23:634-640. 2018
    • Kim KJ, Jeong MH, Lee Y, Hwang SJ, Shin HB, Hur JS, Son YJ. Effect of usnic acid on osteoclatogenic activity. J. Clin. Med. 2018
    • Hwang HG, Kim DH, Lee J, Mo Y, Lee SH, Lee Y, Hyeon JW, Cheon YP, Choi EK, Kim SY, Lee YS, Son YJ, Ryou C. High-Level Production of High-Purity Human and Murine Recombinant Prion Proteins Functionally Compatible to In Vitro Seeding Assay. J. Microbiol. Biotechnol. 28(10) 2018
    • Kim KJ, Lee Y, Hwang HG, Sung SH, Lee M, Son YJ. Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1. J. Clin. Med. 2018
    • Lee Y, Kim JE, Kim KJ, Cho SS, Son YJ. Optimized Extract from Corylopsis coreana Uyeki (Hamamelidaceae) Flos Inhibits Osteoclast Differentiation. Evid. Based Complement Alternat. Med. 2018
    • Lee Y, Hwang YH, Kim KJ, Park AK, Paik MJ, Kim SH, Lee SU, Yee ST, Son YJ. Proteomic and transcriptomic analysis of lung tissue in OVA-challenged mice. Arch. Pharm. Res. 41(1):87-100. 2018
    • Kim KJ, Lee YJ, Hwang YH, Kang KY, Yee ST, Son YJ. In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation. J. Clin. Med. 2017
    • Hwang HG, Kim KJ, Lee SH, Kim CK, Min CK, Yun JM, Lee SU, Son YJ. Recombinant Glargine Insulin Production Process Using Escherichia coli. J. Microbiol. Biotechnol. 26(10):1781-1789. 2016
    • Yeon JT, Kim H, Kim KJ, Lee J, Won DH, Nam SJ, Kim SH, Kang H, Son YJ. Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity. J. Nat. Prod. 79(7):1730-6. 2016
    • Kim KJ, Leutou AS, Yeon JT, Choi SW, Kim SH, Yee ST, Choi KH, Nam SJ, Son YJ. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. Int. J. Endocrinol. 2015: 132436
    • Kim KJ, Yeon JT, Choi SW, Moon SH, Ryu BJ, Yu R, Rark SJ, Kim SH, Son YJ. Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts. Bone 81:208-216. 2015
    • Kim CK, Lee SB, Son YJ. Large-Scale Refolding and Enzyme Reaction of Human Preproinsulin for Production of Human Insulin. J. Microbiol. Biotechnol. 2015
    • Yeon JT, Choi SW, Ryu BJ, Kim KJ, Lee JY, Byun BJ, Son YJ, Kim SH. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. J. Nat. Prod. 78(4):776-82. 2015
    • Park SJ, Lee SH, Kim KJ, Kim SG, Kim H, Choe H, Lee SY, Yun JM, Cho JY, Chun J, Choi KS, Son YJ. Soluble ex-pression and purification of receptor activator of nuclear factor-kappa B ligand using Escherichia coli. J. Microbiol. Biotechnol. 25(2):274-9. 2015
    • Yeon JT, Ryu BJ, Choi SW, Heo JC, Kim KJ, Son YJ, Kim SH. Natural polyamines inhibit h4e migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pah4ways. Amino Acids 46(11):2605-14. 2014
    • Kim H, Kim KJ, Yeon JT, Kim SH, Won DH, Choi H, Nam SJ, Son YJ, Kang H. Placotylene A, an inhibitor of h4e receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp. Mar. Drugs 12(4):2054-65. 2014
    • Yeon JT, Kim KJ, Choi SW, Moon SH, Park YS, Ryu BJ, Oh J, Kim MS, Erkhembaatar M, Son YJ, Kim SH. Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. PLoS One 9(2):e88974. 2014
    • Druz A, Son YJ, Betenbaugh M, Shiloach J. Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metab. Eng. 16:87-94. 2013
    • Min CK, Lee JW, Kim CK, Kim SH, Lee SY, Lee SM, Son YJ. Insulin related compounds and identification. J. Chromatogr. B 908:105-12. 2012
    • Son YJ, Phue JN, Trinh LB, Lee SJ, Shiloach J. The role of Cra in regulating acetate excretion and osmotic tolerance in E.coli K-12 and E.coli B at high density growh4. Microbial Cell Factories. 10(52). 2011.
    • Min CK, Son YJ, Kim CK, Park SJ, Lee JW. Increased ex-pression, folding and enzyme reaction rate of recombinant human insulin by selecting appropriate leader peptide. Journal of Biotechnology. 151(4):350-356. 2011
    • Son YJ, Bae JY, Chong SH, Lee HS, Mo SH, Kim TY, Choe H. High cell density culture and purification of recombinant EC-SOD in Escherichia coli. Applied Biochemistry and Biotechnology. 162(6):1585-1598. 2010
    • Son YJ, Kim CK, Kim YB, Kweon DH, Park YC, Seo JH. Effects of citraconylation on enzymatic modification of human proinsulin using trypsin and carboxypeptidase B. Biotechnology Progress. 25(4):1064-1070. 2009
    • Lee HS, Son YJ, Chong SH, Bae JY, Leem CH, Jang YH, Choe H. Computational analysis of h4e quaternary structural changes induced by point mutations in human UDP-glucose dehydrogenase. Archives of Biochemistry and Biophysics. 486(1):35-43. 2009
    • Son YJ, Kim CK, Choi BT, Park YC, Seo JH. Effects of β-mercaptoeh4anol and hydrogen peroxide on enzymatic conversion of human proinsulin to insulin. Journal of Microbiology and Biotechnology. 18(5):983-989. 2008
    • Son YJ, Rha CS, Park YC, Shin SY, Lee YS, Seo JH. Production of cyclodextrins in ultrafiltration membrane reactor containing cyclodextrin glycosyl- transferase from Bacillus macerans. Journal of Microbiology and Biotechnology. 18(4):725-729. 2008
    • Son YJ, Park KH, Lee SY, Oh SJ, Kim CK, Choi BT, Park YC, Seo JH. Effects of temperature shift strategies on human preproinsulin production in h4e fed-batch fermentation of recombinant Escherichia coli. Biotechnology and Bioprocess Engineering. 12(5):556-561. 2007
  • 장동조 교수 (Dongjo Chang)

    장동조교수 (Dongjo Chang)

    전공
    의약화학
    강의과목
    의약화학, 방사성의약품학
    전화번호
    061) 750-3765
    이메일
    djchang@scnu.ac.kr

    학력

    • 학 사 : 동국대학교
    • 석 사 : 동국대학교
    • 박 사 : 서울대학교

    주요경력

    • 씨트리 신약개발연구소 선임연구원
    • 서울대학교 종합약학연구소 선임연구원
    • University of California, Los Angeles 박사후연구원

    논문

    • Kim, K.; Kim, S. J.; Han, Y. T.; Hong, S. J.; An, H.; Chang, D. J.; Ki, T.; Lim, B.; Lee, J.; Surh, Y. J.; Suh, Y. G. Identification of small molecule inhibitors of h4e STAT3 signaling pah4way: Insights into h4eir structural features and mode of action. Bioorg. Med. Chem. Lett. 2015, In Press.
    • Lee, S.; An, H.; Chang, D. J.; Jang, J.; Kim, K.; Shim, J.; Lee, J.; Suh, Y. G. Total Synh4esis of (-)-deguelin via iterative pyran-ring formation. Chem. Comm. 2015, 51, 9026.
    • Jo, D. H.; An, H.; Chang, D. J.; Baek, Y. Y.; Cho, C. S.; Jun, H. O.; Park, S. J.; Kim, J. H.; Lee, H. Y.; Kim, K. W.; Lee, J.; Park, H. J.; Kim, Y. M.; Suh, Y. G.; Kim, J. H. Hypoxia-Mediated Retinal Neovascularization and Vascular Leakage in Diabetic Retina is Suppressed by HIF-1α Destabilization by SH-1242 and SH-1280, Novel Hsp90 Inhibitor. J. Mol. Med. 2014, 92, 1083.
    • Chang, D. J.; Kim, W. J. Discovery of structurally simplified analogs of colchicine as an immunosuppressant. Bioorg. Med. Chem. Lett. 2014, 24, 3121.
    • Chang, D. J.; An, H.; Kim, K. S.; Park, J. W.; Kim, N. J.; Han, Y. T.; Yun, H.; Lee, S.; Lee, G.; Lee, S.; Cha, J. H.; Park, J. H.; Lee, S. C.; Kim, J. H.; Lee, H. Y; Kim, K. W.; Suh, Y. G. Design, Synh4esis and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein (HSP) 90 Inhibitors Targeting Proliferation and Angiogenesis. J. Med. Chem. 2012, 55, 10863.
    • Chang, D. J.;Lee, S.; Jang, J.; Kim, S. O.; Kim, W. J.; Suh, Y. G. Part II. Development of Novel Colchicine-Derived Immunosuppressant wih4 Improved Pharmacokinetic Properties.Bioorg. Med. Chem.Lett. 2012, 22, 6750.
    • Han, Y. T.; Choi, G. I.; Son, D.; Kim, N. J.; Yun, H.; Lee, S.; Chang, D. J.; Hong, H. S.; Kim, H.; Ha, H. J.; Kim, Y. H.; Park, H. J.; Lee, J.; Suh, Y. G. Ligand-Based Design, Synh4esis, and Biological Evaluation of 2-Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors. J. Med. Chem. 2012, 55. 9120
    • Jang, J.; Jung, J. W.; Ahn, J; Shim, J,; Chang, D. J.; Kim, D. D.; Suh, Y. G. Asymmetric Formal Synh4esis of Schulzeines A and C. Org. Biomol. Chem. 2012, 10, 5202.Yun, H.; Kim, J.; Shim, J.; Lee, S.; Han, Y. T.; Chang, D. J.; Kim, D. D.; Suh, Y. G. Asymmetric Synh4eses of 1-Deoxy-6,8a-di-epi-castanospermine and 1-Deoxy-6-epi-castanospermine. J. Org. Chem. 2012, 77, 5389-5393.
    • Chang, D. J.; Jeong, M.Y.; Song, J.; Chang, Y. J.; Suh, Y. G.; Kim, H. J.; Min, K. H. Discovery of Small Molecules h4at Enhance Astrocyte Differentiation in Rat Fetal Neural Stem Cells. Bioorg. Med. Chem. Lett. 2011, 21, 7050.
    • Kim, N. J.; Moon, H.; Park, T.; Yun, H.; Jung, J. H.; Chang, D. J.; Kim, D. D.; Suh, Y. G. Concise and Enantioselective Total Synh4esis of 15-Deoxy-Δ12,14-Prostaglandin J2. J. Org. Chem., 2010,75, 7458.
    • Lee, Y. S.; Jung, J. H.; Kim, S. H.; Jung, J. K.; Paek, S. M.; Kim, N. J; Chang, D. J.; Suh, Y. G. First Total Synh4esis and Structural Confirmation of Fluvirucinine A2 via an Iterative Ring Expansion Strategy. Org. Lett. 2010, 12, 2040.
    • Paek, S. M.;Kim, N. J.; Shin, D.; Jung, J. K.; Jung, J. H.; Chang, D. J.; Suh, Y. G.A Concise Total Synh4esis of (+)-Tetrabenazine and (+)-α-Dihydrotetrabenazine. Chem- Eur. J. 2010, 16, 4623.
    • Chang, D. J.; Yoon, E. Y.; Lee, G. B.; Kim, S. O.; Kim, W. J.; Kim, Y. M.; Jung, J. W.;  An, H.; Suh, Y. G. Design, Synh4esis and Identification of Novel Colchicine-Derived Immunosuppressant. Bioorg. Med. Chem. Lett. 2009, 19, 4416.
    • Li, F.; Kim, N. J.; Chang, D. J.; Jang, J.; Jang, H.; Jung, J. W.; Min, K. H.; Jeong, Y. S.; Kim, S. Y.; Park, Y. H.; Kim, H. D.; Park, H. G.; Suh, Y. G. Synh4esis and Structural Optimization of Multiple H-Bonding Region of Diarylalkyl (h4io)amides as Novel TRPV1 Antagonists. Bioorgan. Med. Chem. 2009, 17, 8149.
    • Paek, S. M.; Yun, H.; Kim, N. J.; Jung, J. H.; Chang, D. J.; Lee, S. J.; Yoo, J.; Park, H. J.; Suh, Y. G. Concise Synh4eses of (+)-Macrosphelides A and B: Studies on h4e Macro-Ring Closure Strategy. J. Org. Chem. 2009, 74, 554.
    • Chang, D. J.; Kim, W. Y.; Hennessy, B.; Kang, H. J.; Yoo, J.; Han, S. H.; Kim, Y. S.; Park, H. J.; Seo, S. Y.; Mills, G.; Kim, K. W.; Hong, W. K.; Suh, Y. G.; Lee, H. Y. A Novel Derivative of h4e Natural Agent Deguelin for Cancer Chemoprevention and Therapy. Cancer Prev. Res. 2008, 1, 577.
    • Suh, Y. G.; Kim, N. J.; Koo, B. W.; Lee, K. O.; Moon, S. H.; Shin, D. H.; Jung, J. H.; Paek, S. M.; Chang, D. J.; Li, F. Design, Synh4esis, and Biological Evaluation of Novel Constrained meta-Substituted Phenyl Propanoic Acids as Peroxisome Proliferator-Activated Receptor α and γ Dual Agonists. J. Med. Chem. 2008, 51, 6318.
  • 최경희 교수 (Kyung Hee Choi)

    최경희교수 (Kyung Hee Choi)

    전공
    임상약학
    강의과목
    약물치료학, 조제학, 실무실습
    전화번호
    061) 750-3763
    이메일
    khchoi@scnu.ac.kr

    학력

    • 학사 서울대학교 약학대학 약학과
    • 석사 서울대학교 약학대학 임상약학
    • 박사 전남대학교 약학대학 약제학

    주요경력

    • 2018Western University of Health Science (visiting scholar)
    • 2017순천대학교 부교수
    • 2016식품의약품안전처 의약품부작용 심의위원회 위원
    • 2016약학정보원 이사
    • 2015서울대학교병원 약제부 위촉교수
    • 2013순천대학교 조교수
    • 2001서울대학교병원 약제부 약사
    • 2000서울대학교병원 레지던트 약사
    • 1999서울대학교병원 인턴 약사

    논문

    • 국외 논문
    • 1.Yun Mi Yu, Seungyeon Kim, Kyung Hee Choi, Kyeong Hye Jeong, Euni Lee. Impact of knowledge, attitude and preceptor behaviour in pharmacovigilance education. Basic & Clinical Pharmacology & Toxicology (2018) 11 Nov. DOI 10.1111/bcpt.13170.
    • 2.Kyung Hee Choi, Yun Mi Yu, Young-Mi Ah, Min Jung Chang and Ju-Yeun Lee. Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study. BMC Cardiovascular Disorders (2017) 17:232.
    • 3.Yun Jung Choi, Young-Mi Ah, Jisun Kong, Kyung-Hee Choi, Baegeum Kim, Nayoung Han, Yun Mi Yu, Jung Mi Oh, Wan Gyoon Shin, Hae-Young Lee, Ju-Yeun Lee. Implication of different initial beta-blockers on treatment persistence: Atenolol versus New generation beta-blocker, a population-based study. Cardiovascular Therapeutics. 2016:34:268-75.
    • 4.Yu YM, Lee E, Koo BS, Jeong KH, Choi KH, Kang LK, Lee MS, Choi KH, Oh JM, Shin WG. Predictive Factors of Spontaneous Reporting of Adverse Drug Reactions among Community Pharmacists. PLoS One . 2016;11(5):e0155517.
    • 5.Choi Y-J, Lee J-Y, Ah Y-M, Kim B, Choi KH, Kong J, Oh JM, Shin WG and Lee H-Y. Influence of initial angiotensin receptor blockers on treatment persistence in uncomplicated hypertension: A nation-wide population based study. Clinical and Experimental Hypertension. 2016;38(3):325-30.
    • 6.Kyung Hee Choi, Young-Mi Ah, Soo-in Sun, Juyun Kim, Jinjoo Lee, Sooyoung Shin, Ju-Yeun Lee, Sukhyang Lee. Evaluation of Concordance Among Different Drug Information Sources Regarding the Recommendations for Dosage Adjustment in Renal Impairment. International Journal of Clinical Pharmacology & Pharmacotherapy. 2016;1:103
    • 7.Yang Y, Nguyen TT, Jeong MH, Crisan F, Yu YH, Ha HH, Choi KH, Jeong HG, Jeong TC, Lee KY, Kim KK, Hur JS and Kim H. Inhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility. PloS one. 2016;11:e0146575.
    • 8.KJ, Leutou AS, Yeon JT, Choi SW, Kim SH, Yee ST, Choi KH, Nam SJ and Son YJ. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. International journal of endocrinology. 2015;2015:132436.
    • 9.Hwang YH, Kim KJ, Kim JJ, Kang KY, Lee SJ, Jeong GY, Choi KH, Son YJ and Yee ST. Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice. Evidence-based complementary and alternative medicine : eCAM. 2015;2015:373145.
    • 10.Ah Y-M, Lee J-Y, Choi Y-J, Kim B, Choi KH, Kong J, Oh JM, Shin WG and Lee H-Y. Persistence with Antihypertensive Medications in Uncomplicated Treatment-Naïve Patients: Effects of Initial Therapeutic Classes. Journal of Korean medical science. 2015;30:1800-1806.
    • 11.Kim SO, Ah YM, Yu YM, Choi KH, Shin WG and Lee JY. Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2014;113:217-26.
    • 12.Choi KH, Kim AJ, Son IJ, Kim KH, Kim KB, Ahn H and Lee EB. Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting. Journal of Korean medical science. 2010;25:337-41.
    • 국내 논문
    • 1.정선회, 최경희, 권경희, 유기연. 전문약사 자격 보유여부에 따른 전문성 및 직무만족도 영향 분석 병원약사회지. 2018:35: 441-52
    • 2.최경희, 최경숙, 이영숙, 김재연, 정경혜, 오정미, 최경업, 나현오, 김은경. 중동호흡기증후군(MERS) 발생관련 전국 약학대학의 실무실습교육 대응현황. 한국임상약학회지. 2017:27(1):9-13 [제1저자]
    • 3.조의상, 최경희. 류마티스관절염 치료에서 오메가-3 다가불포화지방산의 역할. 병원약사회지. 2016:33: 387-94 [교신저자]
    • 4.강민경, 정선회, 김향숙, 오정미, 최경희. 제 2형 당뇨 환자에서 Sitagliptin과 Sulfonylurea계 약물 병용 시 혈당 조절 효과와 저혈당 발현에 관한 연구. 한국 병원 약사회지. 2014; 31:817-825 [교신저자]
    • 5.이주연, 최경희, 조윤숙, 박경호, 손인자. 순환기내과 병동 담당 약사에 의한 자가약 관리 및 퇴원약 처방 중재 효과.한국 병원 약사회지. 2009; 25:351-361
    • 6.Kim DH, Kim KH, Choi KH, Lee KJ, Lee HS, Son IJ, Kim KB, Lee JW and Ahn H. Dosage Adjustment before and after Warfarin-Rifampin Combination Therapy. The Korean Journal of Thoracic and Cardiovascular Surgery. 2008;41:354-359
    • 7.장소희, 이진주, 최경희, 이순실, 손인자, 김상준. Deep Vein Thrombosis 환자에서 Warfarin 초기용량 5 mg/10 mg의 적절성 평가.한국 병원 약사회지. 2005; 21:91-95
  • 하형호 교수 (HA, Hyung-Ho)

    하형호교수 (HA, Hyung-Ho)

    전공
    의약화학(학장)
    강의과목
    유기약화학, 약품합성학
    전화번호
    061) 750-3754
    이메일
    hhha@scnu.ac.kr

    학력

    • 학 사 : 전북대학교 자연과학대학 화학과
    • 석 사 : 전북대학교 자연과학대학 유기합성
    • 박 사 : 서울대학교 자연과학대학 화학부 의약화학

    주요경력

    • 순천대학교 약학대학 약학과 교수(2020)
    • 순천대학교 약학대학장(2017)
    • (재)순천천연물의약소재개발센터장(2017)
    • 순천대학교 약학대학 약학과 부교수(2015)
    • 순천대학교 약학과장(2014)
    • (재)순천천연물의약소재개발센터 사무국장(2013)
    • 순천대학교 생명약학연구소장(2012)
    • 순천대학교 약학대학 약학과 조교수(2011)
    • 싱가포르 생명과학연구소 의약개발 선임연구원(2010)
    • 싱가포르 화학과, Post-Doc(2009)
    • JW Pharmaceutical 중앙연구소 신약개발팀장(2008)
    • 미국 시애틀 화학유전체학 PNRI연구소 연구원(2004)
    • 일본 로슈 분자의학연구소 연구원(1997)
    • JW Pharmaceutical 중앙연구소 연구원(1995)

    논문

    • Assessing the photocatalytic activity of europium doped TiO2 using liquid phase plasma process on acetylsalicylic acid, Jung SC et al, Catalysis Today, 2020, in press
    • The photocatalytic destruction of cimetidine using microwave-assisted TiO2 photocatalysts hybrid system, Park YK et al, J. Hazard Mater, 2020, 391, 122568
    • Degradation behaviors of naproxen by a hybrid TiO2 photocatalyst system with process components, Jung SC et al, Sci Total Environ, 2020, 708, 135216
    • Fabrication of Yb-doped TiO2 using liquid phase plasma process and its photocatalytic degradation activity of naproxen, Bang HJ et al, J. Mater Sci, 2020, 55(23), 1-11
    • Assessment of Degradation Behavior for Acetylsalicylic Acid Using a Plasma in Liquid Process, Bang HJ et al, Catalysts, 2019, 9(11), 965
    • A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2, Kim JJ et al, J. Am. Chem. Soc. 2019, 141(37), 14673–14686
    • Differences in the Molecular Signatures of Mucosal-Associated Invariant T Cells and Conventional T Cells, Park D et al, Sci Rep., 2019, 9(1), 7094
    • Physciosporin Suppresses the Proliferation, Motility and Tumourigenesis of Colorectal Cancer Cells, Isa Tas et al, Phytomedicine, 2019, 56, 10-20
    • Antimicrobial Activity of Divaricatic Acid Isolated From the Lichen Evernia mesomorpha Against Methicillin-Resistant Staphylococcus aureus, Oh JM et al, molecules, 2018, 23(12), 3068
    • Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer, Yi Yang et al, Sci Rep., 2018, 8(1), 16234
    • Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Yi Yang et al, molecules, 2018, 23(11), 2968
    • Mitochondria are physiologically maintained at close to 50 ˚C, Dominique Chrétien et al, PLoS Biol, 2018, 16(1), e2003992
    • Glycoprotein 90K Promotes E-Cadherin Degradation in a Cell Density-Dependent Manner via Dissociation of E-Cadherin-p120-Catenin Complex, Park SY et al, Int J Mol Sci, 2017, 18(12), 2601
    • ENOblock, a unique small molecule inhibitor of h4e non-glycolytic functions of enolase, alleviates h4e symptoms of type 2 diabetes, Haaglim Cho et al. Scientific Reports, 2017, 7:44186
    • Development of background-free tame fluorescent probes for intracellular live cell imaging, Samira Husen Alamudi et al. NATURE COMMUNICATIONS, 2016
    • Inhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility, Yi Yang et al. PLOS one, 2016, 11(1):e0146575
    • Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility, Yi Yang et al , PLOS one, 2015
    • Mitochondria-targeted fluorescent h4ermometer monitors intracellular temperature gradient, Satoshi Arai et al , Chem. Commun. 2015, 51, 8044-8047.
    • Diversity-Oriented Approach for Chemical Biology, Jun-Seok Lee et al, The Chemical Record. 2015, 15, 495-510
    • Chemical Targeting of GAPDH Moonlighting Function in Cancer Cells Reveals Its Role in Tubulin Regulation, Da-Woon Jung et al , Chemistry & Biology. 2014, 21, 1533-1545,
    • Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development, Yun, S. W. et al , Acc. Chem. Res. 2014, 47, 1277-1286.
    • Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene ex-pression analyses, Park, S. J. et al , Stem Cell Res. 2014, 12, 730-741.
    • A fluorescent probe for imaging symmetric and asymmetric cell division in neurospher formation, Yun, S. W. et al , Chem. Commun. 2014, 50, 7492-7494.
    • Inhibition of tau aggregation by a rosamine derivative h4at blocks tau intermolecular disulfide cross-linking, Haque, M. M. et al , Amyloid 2014, 21, 185-190.
    • Visualization and isolation of Langerhans islets by fluorescent probe PiY, Kang, N. Y. et al , Angew. Chem., Int. Ed. Engl. 2013, 52, 8557-8560
    • A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes, Jung, D. W. et al , ACS Chem. Biol. 2013, 8, 1271-1282.
    • Combinatorial solid-phase synh4esis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and h4eir application to efficient biofuel production, Kim, J. Y. et al , ACS Comb. Sci. 2012, 14, 395-398.
    • A fluorescent screening platform for h4e rapid evaluation of chemicals in cellular reprogramming, Vendrell, M. et al , Stem Cell Res. 2012, 9, 185-191.
    • Solid phase combinatorial synh4esis of a xanh4one library using click chemistry and its application to an embryonic stem cell probe, Ghosh, K. K.; Hyung-Ho Ha.; Kang, N. Y.; Chandran, Y.; Chang, Y. T. Chem. Commun. 2011, 47, 7488-7490.
    • Embryonic and induced pluripotent stem cell staining and sorting using live cell fluorescence imaging probe CDy1, Kang, N. Y.; Yun, S. W.; Hyung-Ho Ha.; Park, S. J.; Chang, Y. T. Nat. Protoc. 2011, 6, 1044-1052.
    • Diversity-driven chemical probe development for biomolecules: beyond hypoh4esis-driven approach, Kang, N. Y.; Hyung-Ho Ha.; Yun, S. W.; Yu, Y. H.; Chang, Y. T. Chem. Soc. Rev. 2011, 40, 3613-3626.
    • Fluorescent labeling of membrane proteins on h4e surface of living cells by a self-catalytic glutah4ione S-transferase omega 1 tag, Lee, J. J.; Son, J.; Hyung-Ho Ha.; Chang, Y. T. Mol. Biosyst. 2011, 7, 1270-1276.
    • The binding of fluorophores to proteins depends on h4e cellular environment, Kim, Y. K.; Lee, J. S.; Bi, X.; Hyung-Ho Ha; Ng, S. H.; Ahn, Y. H.; Lee, J. J.; Wagner, B. K.; Clemons, P. A.; Chang, Y. T. Angew. Chem., Int. Ed. Engl. 2011, 50, 2761-2763.
    • Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects, Jung, D. W.; Hyung-Ho Ha.; Zheng, X.; Chang, Y. T.; Williams, D. R. Mol. Biosyst. 2011, 7, 346-358.
    • A fluorescent rosamine compound selectively stains pluripotent stem cells, Im, C. N.; Kang, N. Y.; Hyung-Ho Ha.; Bi, X.; Lee, J. J.; Park, S. J.; Lee, S. Y.; Vendrell, M.; Kim, Y. K.; Lee, J. S.; Li, J.; Ahn, Y. H.; Feng, B.; Ng, H. H.; Yun, S. W.; Chang, Y. T. Angew. Chem., Int. Ed. Engl., 2010, 49, 7497-7500. (pdf) (SI) Highlighted at "Fluorescence meh4od detects stem cells, C&En News 2010, 88(38), p25"
    • Control of Muscle Differentiation by a Mitochondria-Targeted Fluorophore. Yun Kyung Kim, Hyung-Ho Ha, Jun-Seok Lee, Xuezhi Bi, Young-Hoon Ahn, Siti Hajar, Jae-Jung Lee and Young-Tae Chang. J. Am. Chem. Soc. 2010, 132, 576.
    • Discovery of Novel Zebrafish Neural Tracers by Organism-based Screening of Rosamine Library. Jun Li, Hyung-Ho Ha, Lin Guo, David Coomber, and Young-Tae Chang. Chem. Commun. 2010, 46, 2932-2934.
    • Novel Heterocycle-substituted Pyrimidines as Inhibitors of NF-kB Transcription Regulation Related to TNF-a Cytokine Release. Hyung-Ho Ha, Jee Seon Kim and B. Moon Kim, Bioorg. Med. Chem. Lett. 2008, 18.653
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