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College of Pharmacy

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College of Pharmacy

The objective of the College of Pharmacy, specialized in development of new natural medicine, is to develop pharmacists who can serve to improve health and welfare with initiative according to SCNU’s ideals of education pursuing truth and creativity.
To that end, the College is providing clinical training through pharmacies in Suncheon, Yeosu, and Gwangyang, as well as hospitals including Seoul Nat'l Univ. Hospital, ASAN Medical Center, Seoul Police Hospital, Seoul National Univ. Bundang Hospital, Busan Haeundae Paik Hospital, Pusan National University Yangsan Hospital, Dongtan Hallym Univ. Seongsim Hospital, Bucheon Soon Chun Hyang University Hospital, and Chonnam National Univ. Hospital. In addition, the College has concluded an agreement with Suncheon-si in order to jointly establish a natural pharmaceutical material R&D center, receiving a donation of KRW 10 billion, and is conducting various clinical experiments and new medicine development projects with neighboring hospitals and pharmaceutical companies.

About the Department

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Establishment of the College of Pharmacy is making new history for Sunchon National University, which has over 80 years’ history as a national university based in the Gwangyang Bay Area.

The College of Pharmacy, aiming at development of ‘glocal’ pharmacists, produced the first graduates in 2011 and aspires to be the best college of its kind with active support from all the members and also the alumni association.

Sunchon National University is providing clinical training through pharmacies in Suncheon, Yeosu, and Gwangyang, as well as hospitals including Seoul Nat'l Univ. Hospital, ASAN Medical Center, Seoul Police Hospital, Seoul National Univ. Bundang Hospital, Busan Haeundae Paik Hospital, Pusan National University Yangsan Hospital, Dongtan Hallym Univ. Seongsim Hospital, Bucheon Soon Chun Hyang University Hospital, and Chonnam National Univ. Hospital. In addition, the College has concluded an agreement with Suncheon-si in order to jointly establish a natural pharmaceutical material R&D center, receiving a donation of KRW 10 billion, and is conducting various clinical experiments and new medicine development projects with neighboring hospitals and pharmaceutical companies.

Given the fact that it is located in the Gwangyang Bay Area, the College, specialized in development of medicine for diseases caused by environmental factors, is in good position to utilize a plenty of natural resources distributed in the Jirisan Mountain area and the southern coast of Korea which can be used for developing new medicines.

The College will endeavor to develop global, professional pharmacists, equipped with extensive expertise, the ability of self-development, creativity as well as a strong sense of duty and ethics, who can meet the needs of future society and serve to contribute to public health and local communities.

Teaching Profession

Teaching Profession Department Office
Department Office

061)750-3750

About the Faculty Members

Kim, Min-Sun

  • Name : Kim, Min-Sun
  • Major : Toxicology
  • Lectures : Pharmacology, Toxicology
  • Tel : 061) 750-3756
  • EMAIL : minsun@scnu.ac.kr

Academic Backgrounds

  • B.S. : Pusan National University
  • M.S. : Pusan National University
  • Ph.D. : Oregon State University, USA

Major Career Achievements

  • Examiner of Gastroenterology and Metabolism Products, Drug Evaluation Dept., Korea Food & Drug Administration
  • Research Professor, College of Medicine, Yeungnam University
  • Post-Doc., College of Medicine, Virginia Commonwealth University
  • Post-Doc., Toxicology Center, Oregon Health and Science University

Papers

  • Sung B, Park S, Ha YM, Kim DH, Park CH, Jung KJ, Kim MS, Kim YJ, Kim MK, Moon JO, Yokozawa T, Kim ND, Yu BP, Chung HY. Salicylideneamino-2-thiophenol modulates nuclear factor-κB through redox regulation during the aging process. Geriatr Gerontol Int. 15(2):211-9. 2015
  • Kim H1, Yang I, Patil RS, Kang S, Lee J, Choi H, Kim MS, Nam SJ, Kang H. Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp. J Na Prod. 77(12):2716-9. 2014.
  • Nugroho A, Rhim TJ, Choi MY, Choi JS, Kim YC, Kim MS, Park HJ. Simultaneous analysis and peroxynitrite-scavenging activity of galloylated flavonoid glycosides and ellagic acid in Euphorbia supina. Arch Pharm Res. 37(7):890-8. 2014.
  • Jung HA1, Jung HJ, Jeong HY, Kwon HJ, Kim MS, Choi JS. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 37(6):713-20. 2014.
  • Ji ST, Kim MS, Park HR, Lee E, Lee Y, Jang YJ, Kim HS, Lee J. Diallyl disulfide impairs hippocampal neurogenesis in the young adult brain. Toxicol Lett. 221(1):31-8. 2013.
  • Kim DH, Chung JH, Yoon JS, Ha YM, Bae S, Lee EK, Jung KJ, Kim MS, Kim YJ, Kim MK, Chung HY. Ginsenoside Rd inhibits the ex-pressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver. J Ginseng Res. 37(1):54-63. 2013.
  • Lee Y, Oh SB, Park HR, Kim HS, Kim MS, Lee J. Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption. Neurosci Lett. 535:134-9. 2013.
  • Kim HJ, Lee EK, Park MH, Ha YM, Jung KJ, Kim MS, Kim MK, Yu BP, Chung HY. Ferulate protects the epithelial barrier by maintaining tight junction protein ex-pression and preventing apoptosis in tert-butyl hydroperoxide-induced Caco-2 cells. Phytother Res. 27(3):362-7. 2013.
  • Kim MS, Park HR, Chung HY, Kim HS, Yu BP, Yang HS, Lee J. Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Chem Biol Interact. 194(2-3):139-47. 2011
  • Park HR, Kim MS, Kim SJ, Park M, Kong KH, Kim HS, Kwack SJ, Kang TS, Kim SH, Kim HS, Lee J. Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis. Toxicol Lett. 1;193(1):86-93. 2010.
  • Hong SE, Heo HS, Kim DH, Kim MS, Kim CH, Lee J, Yoo MA, Yu BP, Leeuwenburgh C, Chung HY. Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome. Age (Dordr):32(1):15-30. 2010.
  • Park MJ, Lee EK, Heo HS, Kim MS, Sung B, Kim MK, Lee J, Kim ND, Anton S, Choi JS, Yu BP, Chung HY. The anti-inflammatory effect of kaempferol in aged kidney tissues: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinase pathways. J Med Food. 12(2):351-8. 2009.
  • Kim MS, Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, Kim SH, Lee J. Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. Toxicology. 16:260(1-3):97-103. 2009.
  • Son TG, Park HR, Kim SJ, Kim K, Kim MS, Ishigami A, Handa S, Maruyama N, Chung HY, Lee J. Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis. J Neurosci Res. 87(13):2890-7. 2009.
  • Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol Chem. 283:14497-505. 2008
  • Kim MS, Kim MK, Kim KS, Chung JH, Kim SJ, Kim JH, Kim JR, Lee J, Yu BP, Chung HY. Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress.Toxicology 243:216-23, 2008.
  • Kim, K. S., Kim, M. S., Seu, Y. B., Chung, H. Y., Kim, J. H., Kim, J. R. Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells. Aging Cell. 6:535-45, 2007.
  • Kim MK, Kim KS, Chung JH, Kim JH, Kim JR, Chung HY, Kim MS. Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells. J Toxicol Environ Health A 70:1336-43, 2007

Kim, Hangun

  • Name : Kim, Hangun
  • Major : Pathologic physiology
  • Lectures : Anatomy Physiology, Pathologic Physiology
  • Tel : 061) 750-3761
  • EMAIL : hangunkim@scnu.ac.kr

Academic Backgrounds

  • B.S. : Chonnam National University
  • M.S. : Chonnam National University
  • Ph.D. : Chonnam National University

Major Career Achievements

  • Post-Doc., Pharmacology Class, Gene Control Medical Science Center, College of Medicine, Chonnam National University

Papers

  • Yang et al., Lichen secondary metabolite, Physciosporin, inhibits lung cancer cell motility, PLoS One (2015) 10(9):e0137889
  • Lee et al., Determination of C-terminal δ-catenin responsible for inducing dendritic morphogenesis, J Nanosci Nanotechnol (2015) 15(8):5589-92
  • He et al., δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity, Cell Biol Int (2015) 39(8):954-61
  • Nguyen et al., Lichen secondary metabolites in Flavocetraria cucullata exhibit anti-cancer effects on human cancer cells through the induction of apoptosis and suppression of tumorigenic potentials, PLoS One (2014) 9(10):e111575
  • Park et al., KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis, Mol Ther (2014) 22(9):1653-64
  • He et al., 14-3-3ε/ζ affects the stability of δ-catenin and regulates δ-catenin-induced dendrogenesis, FEBS Open Bio (2012) 3:16-21
  • Kim et al., δ-Catenin promotes E-cadherin processing and activates β-catenin-mediated signaling: implications on human prostate cancer progression, Biochim Biophys Acta (2012) 1822(4):509-21
  • Kim et al., Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk, J. Cell Sci. (2011) 124 (Pt11); 1831-1843
  • Ryu et al., Dyrk1A-mediated phosphorylation of Presenilin-1: a functional link between Down syndrome and Alzheimer's disease, J. Neurochem. (2010) 115(3); 574-584
  • Oh et al., GSK-3 phosphorylates δ-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis, J. Biol. Chem. (2009) 284(42); 28579-28589
  • Jin et al., Regulation of Notch1/NICD and HES1 ex-pression by GSK3a/b, Mol. Cells (2009) 27(1); 15-19
  • Jin et al., Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction, BBA-Molecular Cell Research (2009) 1793; 290-299
  • Kim et al., E-cadherin negatively modulates δ-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for δ-catenin, Biochem. Biophys. Res. Commun. (2008) 377(2); 636-641
  • Kim et al., δ-Catenin induced dendritic morphogenesis: An essential role of p190RhoGEF interaction through Akt1 mediated phosphorylation, J. Biol. Chem. (2008) 283(2); 977-987
  • Kim et al., Presenilin-1 inhibits d-catenin-induced cellular branching and promotes d-catenin processing and turnover. Biochem. Biophys. Res. Commun. (2006) 351, 903-908
  • Kim et al., Presenilin-1 D257A and D385A mutants fail to cleave notch in their endoproteolyzed forms, but only Presenilin-1 D385A mutant can restore its g-secretase activity with the compensatory overex-pression of normal C-terminal fragment. J. Biol. Chem. (2005) 280, 22462-22472

Kim, Hoon

  • Name : Kim, Hoon
  • Major : Biochemistry
  • Lectures : Pharmaceutical Biochemistry
  • Tel : 061) 750-3751
  • EMAIL : hoon@scnu.ac.kr

Academic Backgrounds

  • B.S. : Seoul National University
  • M.S. : Korea Advanced Institute for Science and Technology
  • Ph.D. : Korea Advanced Institute for Science and Technology

Major Career Achievements

  • Dean of College of Pharmacy, Sunchon National University
  • Director of Suncheon Natural Pharmaceutical Material R&D Center
  • Director of Bio-pharmacy Research Laboratory, Sunchon National University
  • Vice-President, Director, and Honam Bracnh Director of Pharmaceutical Society of Korea
  • Leader of Eco-friendly Bioindustry HRD Project
  • Director of Agricultural Science Research Laboratory, Sunchon National University
  • Dean of Agricultural Life Science College, Sunchon National University
  • Visiting Professor of Michigan State University, USA
  • Post-Doc of University of California (San Francisco)
  • Full-time lecturer, assistant professor, associate professor, professor, and dean of Sunchon National University

Papers

  • Bijo Mathew, Della Grace Thomas Parambi, Githa Elizabeth Mathew, Md. Sahab Uddin, Sini T. Inasu, Hoon Kim, Akash Marathakam, M. K. Unnikrishnan, Simone Carradori, “Therapeutic potentials of dual-acting monoamine oxidase inhibitors in Alzheimer’s and Parkinson’s diseases”, (2019. 9. 3 Online) Archiv der Pharmazie. e1900177.
  • Seetha Harilal, Jobin Jose, Della Grace Thomas Parambi, Rajesh Kumar, Githa Elizabeth Mathew, Md. Sahab Uddin, Hoon Kim and Bijo Mathew, “Advancements in nanotherapeutics for Alzheimer’s disease: current perspectives”, (2019. 7. 15 Online; 9. 1) Journal of Pharmacy and Pharmacology, 71, 1370–1383.
  • Jong Min Oh, Myung-Gyun Kang, Ahreum Hong, Ji-Eun Park, Soo Hyun Kim, Jae Pil Lee, Seung Cheol Baek, Daeui Park, Sang-Jip Nam, Myoung-Lae Cho, Hoon Kim, “Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives”, (2019. 7. 2 Online; 9. 15) International Journal of Biological Macromolecules. 137, 426-432.
  • Jae Pil Lee, Myung-Gyun Kang, Joon Yeop Lee, Jong Min Oh, Seung Cheol Baek, Hyun Hee Leem, Daeui Park, Myoung-Lae Cho, Hoon Kim, “Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds”, Bioorganic Chemistry (2019. 6. 6 Online; 8. 1) 89, 103043.
  • Balasubramanian Lakshminarayanan, Seung Cheol Baek, Jae Pil Lee, Nagappan Kannappan, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Thillainayagam Subburaju, Hoon Kim, Bijo Mathew, “Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors”, (2019. 6. 6) Chem Select 4, 6614-6619.
  • Bijo Mathew, Seung Cheol Baek, Della Grace Thomas Parambi, Jae Pil Lee, Githa Elizabeth Mathew, Sivaraman Jayanthi, Vinod Devaraji, Clariya Rapheal, V. Devikrishna, K. Shain Shad, Md. Sahab Uddin, Hoon Kim, “Potent and highly selective dual-targeting monoamine oxidase-B inhibitors: Fluorinated chalcones of morpholine versus imidazole”, Archiv der Pharmazie (2019. 1. 21 Online; 4. 1). e1800309.
  • Seung Cheol Baek, Myung-Gyun Kang, Ji-Eun Park, Jae Pil Lee, Hanna Lee, Hyung Won Ryu, Chul Min Park, Daeui Park, Myoung-Lae Cho, Sei-Ryang Oh, Hoon Kim, “Osthenol, a Prenylated Coumarin, as a Monoamine Oxidase A Inhibitor with High Selectivity”, (2019. 01. 18 Online; 3. 15) Bioorganic & Medicinal Chemistry Letters. 29, 839-843.
  • Jong Min Oh, Yi Jeong Kim, Hyo-Seung Gang, Jin Han, Hyung-Ho Ha, Hoon Kim, “Antimicrobial activity of divaricatic acid isolated from the lichen Evernia mesomorpha against methicillin-resistant Staphylococcus aureus”, (2018. 11. 23) Molecules. 23, 3068.
  • Seung Cheol Baek, Mi Hyeon Park, Hyung Won Ryu, Jae Pil Lee, Myung-Gyun Kang, Daeui Park, Chul Min Park, Sei-Ryang Oh, Hoon Kim, “Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A”, (2018. 10. 28 Online; 2019. 03. 01) Bioorganic Chemistry. 83, 317–325.
  • Jae Pil Lee, Eun-Sun Shin, Min Yeol Cho, Kyung-Dong Lee, and Hoon Kim, “Roles of carbohydrate-binding module (CBM) of an endo-β-1,4-glucanase (Cel5L) from Bacillus sp. KD1014 in thermostability and small-substrate hydrolyzing activity”, (2018. 10. 26 Online; 12. 28) J. Microbiol. Biotechnol. 28, 757-764.
  • Bijo Mathew, Seung Cheol Baek, Della Grace Thomas Parambi, Jae Pil Lee, Monu Joy, P. R. Annie Rilda, Rugma V. Randev, P. Nithyamol, Vijitha Vijayan, Sini T. Inasu, Githa Elizabeth Mathew, Krishnakumar K. Lohidakshan, Girish Kumar Krishnan, Hoon Kim, “Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors”, (2018. 9. 25 Online; 2018. 11. 1) MedChemComm. 1871-1881.
  • Rani Sasidharan, Seung Cheol Baek, Sreedharannair Leelabaiamma Manju, Hoon Kim, Bijo Mathew, “Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors”, (2018. 06. 23 Online; 10. 1) Biomedicine & Pharmacotherapy. 106, 8-13.
  • Seung Cheol Baek, Hyung Won Ryu, Myung-Gyun Kang, Hanna Lee, Daeui Park, Myoung-Lae Cho, Sei-Ryang Oh, Hoon Kim, “Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid”, (2018. 06. 18 Online; 08. 01) Bioorganic & Medicinal Chemistry Letters. 28, 2403-2407.
  • Jae Pil Lee, HyunWoo Lee, Han Beur Na, Jun-Hee Lee, Yeo-Jin Hong, Jeong-Min Jeon, Eun Ju Kwon, Sung Kyum Kim, Hoon Kim, “Characterization of truncated endo-β-1,4-glucanases from a compost metagenomic library and their saccharification potentials”, (2018. 04. 23 Online; 08. 01) International Journal of Biological Macromolecules 115, 554–562.
  • Jae Pil Lee, Yoon A Kim, Sung Kyum Kim, Hoon Kim, “Characterization of a multimodular endo-β-1,4-glucanase (Cel9K) from Paenibacillus sp. X4 with a potential additive for saccharification”, (2018. 02. 01 Online; 04. 27) J. Microbiol. Biotechnol. 28, 588-596.
  • Seung Cheol Baek, Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Soo Hyun Kim, Myoung-Lae Cho, Sei-Ryang Oh, Hoon Kim, “Selective inhibition of monoamine oxidase A by hispidol”, (2018. 01. 31 Online; 02. 15) Bioorganic & Medicinal Chemistry Letters. 28, 584-588.
  • Jong Min Oh, Jae Pil Lee, Seung Cheol Baek, Seul Gi Kim, Yang Do Jo, Jungho Kim, Hoon Kim, “Characterization of two extracellular β-glucosidases produced from the cellulolytic fungus Aspergillus sp. YDJ216 and their potential applications for the hydrolysis of flavone glycosides”, (2018. 01. 12 Online; 05. 01) International Journal of Biological Macromolecules. 111, 595-603.
  • Jerad Suresh, Seung Cheol Baek, Surya Parakkot Ramakrishnan, Hoon Kim, Bijo Mathew, “Discovery of potent and reversible MAO-B inhibitors as furanochalcones”, (2017. 11. 28 Online; 2018. 03. 01) International Journal of Biological Macromolecules. 108, 660-664.
  • Yu Jin Jeong, Seung Cheol Baek, Hoon Kim, “Cloning and characterization of a novel intracellular serine protease (IspK) from Bacillus megaterium with a potential additive for detergents”, (2017. 10. 31 Online; 2018. 03. 01) International Journal of Biological Macromolecules. 108, 808-816.
  • Hyun Woo Lee, Hyung Won Ryu, Seung Cheol Baek, Myung-Gyun Kang, Daeui Park, Hyoung-Yun Han, Ju Hyeon An, Sei-Ryang Oh, Hoon Kim, “Potent inhibitions of monoamine oxidase A and B by acacetin and its 7-O-(6-O-malonylglucoside) derivative from Agastache rugosa”, (2017. 06. 19 Online; 11. 01) International Journal of Biological Macromolecules. 104, 547-553.
  • Seung Cheol Baek, Thien-Hoang Ho, Hyun Woo Lee, Won Kyeong Jung, Hyo-Seung Gang, Lin-Woo Kang, Hoon Kim, “Improvement of enzyme activity of β-1,3-1,4-glucanase from Paenibacillus sp. X4 by error-prone PCR and structural insights of mutated residues”, (2017. 05. 15; 02. 08 Online) Applied Microbiology and Biotechnology. 101, 4073-4083.
  • Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Sei-Ryang Oh, Hoon Kim, “Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone”, (2017. 01. 31 Online; 03. 01) Bioorganic & Medicinal Chemistry Letters. 27, 1136-1140.
  • Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Hanna Lee, Heung Mook Shin, Sei-Ryang Oh, Hoon Kim, “Potent inhibition of monoamine oxidase A by decursin from Angelica gigas Nakai and by wogonin from Scutellaria baicalensis Georgi”, (2017. 01. 18 Online; 04. 01) International Journal of Biological Macromolecules. 97, 598-605.
  • Mi-Jeong Yang, Hyun Woo Lee, and Hoon Kim, “Enhancement of thermostability of Bacillus subtilis endoglucanase by error-prone PCR and DNA shuffling”, (2017. 01. 16 Online; 02. 28) Applied and Biological Chemistry. 60, 73-78.
  • Hyun Woo Lee, Hansol Choi, Sang-Jip Nam, William Fenical, Hoon Kim, “Potent Inhibition of Monoamine Oxidase B by a piloquinone from marine-derived Streptomyces sp. CNQ-027”, (2017. 01. 09 Online; 04. 28) J. Microbiol. Biotechnol. 27, 785-790.
  • Hyun Woo Lee, Yeon Ji Kim, Sang-Jip Nam, and Hoon Kim, “Potent selective inhibition of monoamine oxidase A by alternariol monomethyl ether isolated from Alternaria brassicae”, (2016. 11. 14 Online; 2017. 02. 28) J. Microbiol. Biotechnol. 27, 316-320.
  • Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Sei-Ryang Oh, and Hoon Kim, “Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens”, (2016. 08. 18 Online; 10. 01) Bioorganic & Medicinal Chemistry Letters. 26, 4714-4719.
  • Hyun Woo Lee, Won Kyeong Jung, Yong Ho Kim, Bum Han Ryu, T. Doohun Kim, Jungho Kim, and Hoon Kim, “Characterization of a novel alkaline family VIII esterase with S-enantiomer preference from a compost metagenomic library”, (2016. 02) J. Microbiol. Biotechnol. 26, 315-325.
  • Hee Jung Kim, Won Kyeong Jung, Hyun Woo Lee, Wanki Yoo, T. Doohun Kim, and Hoon Kim, “Characterization of an alkaline family I.4 lipase from Bacillus sp. W130-35 isolated from a tidal mud flat with broad substrate specificity”, (2015. 12) J. Microbiol. Biotechnol. 25, 2024–2033.
  • Hyun Woo Lee, Won Kyeong Jung, Hee Jung Kim, Yu Seok Jeong, Sang-Jip Nam, Heonjoong Kang, and Hoon Kim, "Inhibition of monoamine oxidase by anithiactins from Streptomyces sp.", (2015. 09) J. Microbiol. Biotechnol. 25, 1425–1428.
  • Hee Jung Kim, Yu Seok Jeong, Won Kyeong Jung, Sung Kyum Kim, Hyun Woo Lee, Hyung-Yeel Kahng, Jungho Kim, and Hoon Kim, "Characterization of novel family IV esterase and family I.3 lipase from an oil-polluted mud flat metagenome", (2015. 09) Mol Biotechnol 57, 781–792.
  • Han Beur Na, Won Kyeong Jung, Yu Seok Jeong, Hee Jung Kim, Sung Kyum Kim, Jungho Kim, Han Dae Yun, Jung-Kul Lee, and Hoon Kim, "Characterization of a GH family 8 b-1,3-1,4-glucanase with distinctive broad substrate specificity from Paenibacillus sp. X4", (2015. 03) Biotechnol Lett 37, 643-655.
  • Sung Kyum Kim, Yong Ho Kim, Yu Seok Jeong, Han Beur Na, Jungho Kim, Keun Sik Baik, Han Dae Yun, Jung-Kul Lee, and Hoon Kim, "Chitinibacter suncheonensis sp. nov., a chitinolytic bacterium from a mud flat in Suncheon Bay", (2012. 12) The Journal of Microbiology 50(6): 1058–1062.
  • Nguyen Dinh Phuong, Yu Seok Jeong, Thangaswamy Selvaraj, Sung Kyum Kim, Yong Ho Kim, Kyung Hwa Jung, Jungho Kim, Han Dae Yun, Sui-Lam Wong, Jung-Kul Lee, and Hoon Kim, "Production of XynX, a large multimodular protein of Clostridium thermocellum, by protease-deficient Bacillus subtilis strains", (2012. 09) Appl Biochem Biotechnol 168:375–382. Erratum: “Production of XynX, a Large Multimodular Protein of Thermoanaerobacterium sp., by Protease-Deficient Bacillus subtilis Strains”, (2012. 11) Appl Biochem Biotechnol 168:1349–1350.
  • Yu Seok Jeong, Han Beur Na, Sung Kyum Kim, Yong Ho Kim, Eun Ju Kwon, Jungho Kim, Han Dae Yun, Jung-Kul Lee, and Hoon Kim. “Characterization of Xyn10J, a novel family 10 xylanase from a compost metagenomic library”, (2012. 03) Appl Biochem Biotechnol 166:1328–1339.
  • Thangaswamy Selvaraj, Sung Kyum Kim, Yong Ho Kim, Yu Seok Jeong, Yu-Jeong Kim, Nguyen Dinh Phuong, Kyung Hwa Jung, Jungho Kim, Han Dae Yun, and Hoon Kim, “The role of carbohydrate-binding module (CBM) repeat of a multimodular xylanase (XynX) from Clostridium thermocellum in cellulose and xylan binding”, (2010, 12) J. Microbiol. 48(6), 856-861.
  • Yong Ho Kim, Eun Ju Kwon, Sung Kyum Kim, Yu Seok Jeong, Jungho Kim, Han Dae Yun, and Hoon Kim, “Molecular cloning and characterization of a novel family VIII alkaline esterase from a compost metagenomic library”, (2010.02), Biochemical and Biophysical Research Communications. 393, 45-49.
  • Seur Kee Park, Chi Wook Kim, Hoon Kim, Jae Sung Jung, and G. E. Harman. “Cloning and high-level production of a chitinase from Chromobacterium sp. and the role of conserved or nonconserved residues on its catalytic activity”, (2007. 03), Applied Microbiology and Biotechnology. 74, 791-804.
  • Kye Man Cho, Su Young Hong, Sun Mi Lee, Yong Hee Kim, Goon Gjung Kahng, Hoon Kim, and Han Dae Yun. “A cel44C-man26A gene of endophytic Paenibacillus polymyxa GS01 has multi-glycosyl hydrolases in two catalytic domains”, (2006. 11), Applied Microbiology and Biotechnology. 73, 618-630.
  • Takuji Oka, Yuka Sameshima, Tomoko Koga, Hoon Kim, Masatoshi Goto, and Kensuke Furukawa. “Protein O-mannosyltransferase A of Aspergillus awamori is involved in O-mannosylation of glucoamylase I”, (2005. 11. 04), Microbiology-SGM. 151, 3657-3667.
  • Thangaswamy Selvaraj, Padmanabhan Chellappan, Yu Jin Jeong, and Hoon Kim. “Occurrence and quantification of vesicular-arbuscular mycorrhizal (VAM) fungi in industrial polluted soils”, (2005. 2), Journal of Microbiology and Biotechnology. 15(1), 147-154.
  • Mi-Jeong Yang, Sun-Hwa Jung, Eun-Sun Shin, Jungho Kim, Han Dae Yun, Sui-Lam Wong, and Hoon Kim. “ex-pression of a Bacillus subtilis endoglucanase in protease-deficient Bacillus subtilis strains”, (2004), Journal of Microbiology and Biotechnology. 14(2), 430-434.
  • Eun-Sun Shin, Mi-Jeong Yang, Kyung Hwa Jung, Eun-Ju Kwon, Jae Sung Jung, Seur Kee Park, Jungho Kim, Han Dae Yun, and Hoon Kim. “Influence of the transposition of the thermostabilizing domain of Clostridium thermocellum Xylanase (XynX) on xylan-binding and thermostabilization”, (2002), Applied and Environmental Microbiology. 68(7), 3496-3501.
  • Hoon Kim, Joong-Hoon Ahn, Jenifer M. Gorlach, Claudio Caprari, John S. Scott-Craig, and Jonathan D. Walton. “Mutational analysis of two-β-glucanase genes from the plant pathogenic fungus Cochliobolus carbonum”, (2001), Molecular Plant-Microbe Interactions. 14, 1436-1443.
  • Hoon Kim, K. H. Jung, and M. Y. Pack. “Molecular characterization of xynX, a gene encoding a multidomain xylanase with a thermostabilizing domain from Clostridium thermocellum”, (2000) Applied Microbiology and Biotechnology. 54, 521-527.
  • Hoon Kim, He-sug Ju, and Jungho Kim. “Characterization of an extracellular poly(3-hydroxy-5-phenylvalerate) depolymerase from Xanthomonas sp. JS02”, (2000), Applied Microbiology and Biotechnology. 53, 323-327.
  • Hoon Kim, Masatoshi Goto, Heo-Jin Jeong, Kyung Hwa Jung, Il Kwon, and Kensuke Furukawa. “Functional analysis of a hybrid endoglucanase of bacterial origin having a cellulose-binding domain of fungal exoglucanase”, (1998), Applied Biochemistry and Biotechnology. 75(2-3), 193-204.
  • Hoon Kim, Sergey O. Sablin, and Rona R. Ramsay. “Inhibition of monoamine oxidase A by β-carboline derivatives”, (1997), Archives Biochemistry and Biophysics. 337 (1), 137-142.
  • Dong Ho Ahn, Hoon Kim, and M. Y. Pack. "Cleavage of Bacillus subtilis endo-β-1,4-glucanase by B. megaterium protease", Biotechnol. Lett. (1993), 15 (2), 127-132.
  • Hoon Kim, Sungmin F. Kim, and M. Y. Pack. "C-Terminal Processing of Bacillus subtilis BSE616 Endo-β-1,4-glucanase in Bacillus megaterium", Biotechnol. Lett. (1991), 13(11), 799-804.
  • Hoon Kim, and M. Y. Pack. "Endo-β-1,4-glucanase Encoded by Bacillus subtilis Gene Cloned in Bacillus megaterium", Enzyme and Microbial Technology, (1988), 10, 347-351.

Moon, Cheol

  • Name : Moon, Cheol
  • Major : Pharmacology
  • Lectures : Pharmacology, Drug Delivery Systems
  • Tel : 061) 750-3758
  • EMAIL : cheolm@scnu.ac.kr

Academic Backgrounds

  • B.S. : Seoul National University
  • M.S. : Seoul National University
  • Ph.D. : University of Michigan, Ann Arbor (2007)

Major Career Achievements

  • Researcher, Biotech Research Lab, LG Chem R&D Campus
  • Post-Doc, University of Michigan, Ann Arbor, USA
  • NAL Pharmaceuticals, Manager, Technology Development

Papers

  • D. H. Truong, T. H. Tran, T. Ramasamy, J. Y. Choi, H. H. Lee, C. Moon, H. G. Choi, C. S. Yong, and J. O. Kim. "Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib." AAPS PharmSciTech. E-published (2015-8-4)
  • J. Tan, H. Cheong, Y. S. Park, H. Kim, M. Zhang, C. Moon, and Y. Huang. "Cell-penetrating peptide-mediated topical delivery of biomacromolecular drugs." Curr Pharm Biotechnol. 15:231-239, 2014
  • M. C. Shin, J. Zhang,,K. A. Min, K. Lee, C. Moon, J. P Balthasar, and V. C. Yang. "Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy." J Control Release. 194:197-210, 2014
  • K. H. Kim, S. A. Cho, J. Y. Lim, C. Moon, and S. H. Jeong "Preparation of microcapsules with the evaluation of physicochemical properties and molecular interaction" Arch. Pharm. Res. 37: 1570-1577, 2014
  • A. E. David, J. Gong, B. Chertok, R.C. Domszy, C. Moon, Y. S. Park, N. S. Wang, A. J. Yang, and V. C. Yang, "Immobilized thermolysin for highly efficient production of low molecular weight protamine - an attractive cell - penetrating peptide for macromolecular drug delivery applications. "J. Biomed. Mater. Res. A. 100A: 211-219, 2012
  • R. K. Subedi, J. P. Ryoo, C. Moon, and H. K. Choi, "Influence of formulation variables in transdermal drug delivery system containing zolmitriptan" Int. J. Pharm. 419:209-214, 2011
  • Y. Huang, Y. S. Park, C. Moon, A. E. David, H. S. Chung, and V. C. Yang, "Synthetic skin-permeable antigens enabling transcutaneous immunization" Angew. Chem. Int. Ed. 49:2724-2727, 2010
  • Y. M. Kwon, H. S. Chung, C. Moon, J. Yockman, Y. J. Park, S. D. Gitlin, A. E. David, and V. C. Yang, "L-Asparaginase encapsulated intact erythrocytes for treatment of acute lymphoblastic leukemia (ALL)" J. Controlled Release 139(3):182-189, 2009
  • C. Moon, Y. M. Kwon, W. K. Lee, Y. J. Park, L. C. Chang, and V. C. Yang, "A novel polyrotaxane-based intracellular delivery system for camptothecin: In vitro feasibility evaluation" J. Biomed. Mater. Res A. 84: 238-246, 2008
  • C. Moon, Y. M. Kwon, W. K. Lee, Y. J. Park, and V. C. Yang, "In vitro assessment of a novel polyrotaxane-based drug delivery system integrated with a cell-penetrating peptide." J. Control. Release 124:43-50, 2007
  • Y. J. Park, L. C. Chang, J. F. Liang, C. Moon, C. P. Chung, and V. C. Yang, "Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: in vitro and in vivo study." FASEBJ. 19(11):1555-1557, 2005

Park, Ae Kyung

  • Name : Park, Ae Kyung
  • Major : Public Health (Public Health Statistics)
  • Research Area : Bioinformatics & Biostatistics in cancer genomics & epigenomics
  • Lectures : Preventive Pharmacy, Pharmaceutical Statistics, and Pharmaceutical Information
  • Tel : 061) 750-3757
  • EMAIL : parkak11@scnu.ac.kr

Academic Backgrounds

  • B.S. : College of Pharmacy, Seoul National University
  • M.S. : College of Pharmacy, Seoul National University (Major of Biochemistry)
  • Ph.D. : Graduate School of Public Health, Seoul National University (Major of Health Statistics)

Major Career Achievements

  • Researcher of Korea Institute of Science and Technology (1991)
  • Full-time lecturer and assistant professor, Shinsung University (1998-2005)
  • Post-Doc, College of Medicine, Seoul National University (2009-2011)
  • Assistant professor, College of Pharmacy, Sunchon National University (2011-2015)

Papers

  • 1) SCI(SCIE)
    • Moon HG, Oh K, Lee J, Lee M, Kim JY, Yoo TK, Seo MW, Park AK, Ryu HS, Jung EJ, Kim N, Jeong S, Han W, Lee DS, Noh DY. Prognostic and functional importance of the engraftment-associated genes in the patient-derived xenograft models of triple-negative breast cancers. Breast Cancer Res Treat. 2015 Oct 5.
    • Lee JY, Moon YJ, Lee HO, Park AK, Choi SA, Wang KC, Han JW, Joung JG, Kang HS, Kim JE, Phi JH, Park WY, Kim SK. Deregulation of Retinaldehyde Dehydrogenase 2 Leads to Defective Angiogenic Function of Endothelial Colony-Forming Cells in Pediatric Moyamoya Disease. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1670-7.
    • Lee SW, Kim M, Kim H, Han SS, Lee H, Lee JP, Kim DK, Lim CS, Kim YS, Park AK, Joo KW. Obesity modifies the association between serum 25-hydroxyvitamin D and insulin resistance in Korean general population without increased fasting glucose levels. Tohoku J Exp Med. 2014;234(2):89-97
    • Sung HY, Park AK, Ju W, Ahn JH. Overex-pression of mucin 13 due to promoter methylation promotes aggressive behavior in ovarian cancer cells. Yonsei Med J. 2014 Sep;55(5):1206-13
    • Sung HY, Choi EN, Lyu D, Park AK, Ju W, Ahn JH. Aberrant hypomethylation-mediated AGR2 overex-pression induces an aggressive phenotype in ovarian cancer cells. Oncol Rep. 2014 Aug;32(2):815-20.
    • Hong CE, Park AK, Lyu SY. Synergistic anticancer effects of lectin and doxorubicin in breast cancer cells. Mol Cell Biochem. 2014 Sep;394(1-2):225-35
    • Lee JY, Park AK, Lee ES, Park WY, Park SH, Choi JW, Phi JH, Wang KC, Kim SK. miRNA ex-pression analysis in cortical dysplasia: regulation of mTOR and LIS1 pathway. Epilepsy Res. 2014 Mar;108(3):433-41
    • Kang HS, Moon YJ, Kim YY, Park WY, Park AK, Wang KC, Kim JE, Phi JH, Lee JY, Kim SK. Smooth-muscle progenitor cells isolated from patients with moyamoya disease: novel experimental cell model. J Neurosurg. 2014 Feb;120(2):415-25
    • Jeon S, Han S, Lee K, Choi J, Park SK, Park AK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Kim H, Ahn Y, Kang D. Genetic variants of AICDA/CASP14 associated with childhood brain tumor. Genet Mol Res. 2013 Jun 20;12(2):2024-31
    • Takwi AA, Li Y, Becker Buscaglia LE, Zhang J, Choudhury S, Park AK, Liu M, Young KH, Park WY, Martin RC, Li Y. A statin-regulated microRNA represses human c-Myc ex-pression and function. EMBO Mol Med. 2012 Sep;4(9):896-909
    • Han S, Koo HH, Lan Q, Lee KM, Park AK, Park SK, Sung H, Ahn HS, Shin HY, Kang HJ, Seo JJ, Ahn YO, Kim H, Rothman N, Kang D. Common variation in genes related to immune response and risk of childhood leukemia. Hum Immunol. 2012 Mar;73(3):316-9
    • Park AK, Lee SJ, Phi JH, Wang KC, Kim DG, Cho BK, Haberler C, Fattet S, Dufour C, Puget S, Sainte-Rose C, Bourdeaut F, Grill J, Delattre O, Kim SK, Park WY. Prognostic classification of pediatric medulloblastoma based on chromosome 17p loss, ex-pression of MYCC and MYCN, and Wnt pathway activation. Neuro Oncol. 2012 Feb;14(2):203-14.
    • Oh K, Ko E, Kim HS, Park AK, Moon HG, Noh DY, Lee DS. Transglutaminase 2 facilitates the distant hematogenous metastasis of breast cancer by modulating interleukin-6 in cancer cells. Breast Cancer Res. 2011 Oct 3;13(5):R96.
    • Arora H, Qureshi R, Park AK, Park WY. Coordinated regulation of ATF2 by miR-26b in γ-irradiated lung cancer cells. PLoS One. 2011;6(8):e23802
    • Arora H, Qureshi R, Jin S, Park AK, Park WY. miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1. Exp Mol Med. 2011 May 31;43(5):298-304
    • Jin X, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, Kang BG, Beck S, Lee SJ, Kim JK, Park AK, Park WY, Choi YJ, Nam DH, Kim H. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res. 2011 Apr 15;71(8):3066-75.
    • Lim YH, Park AK, Kim H. Modifiers of diurnal temperature range and mortality association in six Korean cities. Int J Biometeorol. 2012 Jan;56(1):33-42.
    • Park AK, Hong YC, Kim H. Effect of changes in season and temperature on mortality associated with air pollution in Seoul, Korea. J Epidemiol Community Health. 2011 Apr;65(4):368-75.
    • Park AK, Kim H, Jin HJ. Phylogenetic analysis of rRNA methyltransferases, Erm and KsgA, as related to antibiotic resistance. FEMS Microbiol Lett. 2010 Aug 1;309(2):151-62
    • Kim EH, Park AK, Dong SM, Ahn JH, Park WY. Global analysis of CpG methylation reveals epigenetic control of the radiosensitivity in lung cancer cell lines. Oncogene. 2010 Aug 19;29(33):4725-31
    • Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D. Polymorphisms in innate immunity genes and risk of childhood leukemia. Hum Immunol. 2010 Jul;71(7):727-30
    • Han W, Kang SY, Kang D, Park SK, Lee JY, Kim H, Park AK, Noh DY. Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk. Oncol Rep. 2010 Mar;23(3):763-9
    • Lee JY, Park AK, Lee KM, Park SK, Han S, Han W, Noh DY, Yoo KY, Kim H, Chanock SJ, Rothman N, Kang D. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. Carcinogenesis. 2009 Sep;30(9):1528-31
    • Park AK, Kim H, Jin HJ. Comprehensive phylogenetic analysis of evolutionarily conserved rRNA adenine dimethyltransferase suggests diverse bacterial contributions to the nucleus-encoded plastid proteome. Mol Phylogenet Evol. 2009 Feb;50(2):282-9
  • Domestic Papers
    • Park AK., Kim H. Review of Power and Sample Size Estimation in Genomewide Association Studies, Journal of Preventive Medicine and Public Health (J Prev Med Public Health). 2007 Mar;40(2):114-21

Paik, Man-Jeong

  • Name : Paik, Man-Jeong
  • Major : Pharmaceutical Analysis
  • Lectures : Pharmaceutical Analysis
  • Tel : 061) 750-3762
  • EMAIL : paik815@scnu.ac.kr

Academic Backgrounds

  • B.S. : University of Suwon
  • M.S. : Sungkyunkwan University
  • Ph.D. : Sungkyunkwan University

Major Career Achievements

  • Research professor, Molecular Science and Technology Dept. Ajou University
  • Expert member, Ministry of Education, Science and Technology
  • Participating professor, BK21 Molecular Science and Technology Project, Ajou University
  • Assistant Professor, Neurotization Stem Cell Research Lab, College of Medicine, Ajou University
  • Research assistant professor, College of Pharmacy, Sungkyunkwan University
  • National Institute of Environmental Research- Environmental Testing/Inspection Agency Quality Control Committee Member (July 2015 – up to now)
  • Basic Laboratory Support Project – Director of the Environmental Respiratory Disease Omics Lab (Sep. 2015 ~ up to now)

Major Career Achievements

  • Paik M-J, Kim H-S, Lee Y-S, Choi H-D, Pack J-K, Kim N, Ahn Y-H (2015) Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal. Amino Acids. In press
  • Seo C, Yoon J, Rhee Y, Kim J-J, Name S-J, Lee W, Lee G, Yee S-T, Paik M-J (2015) Simultaneous analysis of seven 2-hydroxy fatty acids as tert-butyldimethylsilyl derivatives in plasma by gas chromatography-mass spectrometry Biomedical Chromatography, 29, 156-160.
  • Hur H, Paik M-J, Xuan Y, Nguyen D-T, Ham I-H, Yun J, Cho Y-K, Lee G, Han S-U (2014) Quantitative measurement of organic acids in tissues from gastric cancer patients indicates increased glucose metabolism in gastric cancer. PLOS one, 9, 1-9.
  • Paik M-J, Kim D-K, Nguyen D-T, Lee G, Rhee C-S, Yoon I-Y, Kim J-W (2014) Correlation of daytime sleepiness with urine metabolites in patients with obstructive sleep apnea. Sleep Breath, 18, 517-523.
  • Paik M-J, Kang J-S, Huang B-S, Carey J-R, Lee W (2013) Development and application of chiral crown ethers as selectors for chiral separation in high-performance liquid chromatography and nuclear magnetic resonance spectroscopy. Journal of Chromatography A. 1274, 1-5.
  • Nguyen D-T, Lee G, Paik M-J (2013) Keto acid profiling analysis as ethoxime/tert-butyldimethylsilyl derivatives by gas chromatography-mass spectrometry. Journal of Chromatography B, 913-914, 48-54.
  • Shim W-Y+, Paik M-J+, Nguyen D-T, Lee J-K, Lee Y, Ho Kim J-H, Shin E-H, Kang J-S, Jung H-S, Choi S, Park S, Shim J-S, Lee G (2012) Analysis of changes in gene ex-pression and metabolic profiles induced by silica-coated magnetic nanoparticles. ACS Nano, 6(9), 7665-7680
  • Nguyen D-T, Kim K-R, Lee G, and M-J Paik (2012) Chiral separation of N-methyl-DL-aspartic acid in rat brain tissue as N-ethoxycarbonylated (S)-(+)-2-octylesterderivatives by GC-MS, Biomedical Chromatography, in press.
  • Paik M-J, Shin J-Y, Lee G, and Ahn Y-H (2011)Monitoring of altered free fatty acid metabolic patterns in rat plasma following hemorrhagic stroke. Analytical Letters, 44, 1323-1332.
  • Yu J, Han K-S. Lee G, Paik M-J, and Kim K-R (2010) Enantiomeric composition analysis of pranoprofen in equine plasma and urine by chiral liquid chromatography-tandem mass spectrometry in selected reaction monitoring mode, Journal of Chromatography B, 878, 3249-3254.
  • Paik M-J, Ahn Y-H, Lee P-H, Kang H, Park C-B, Choi S, and Lee G (2010) Polyamine Patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy, Clinica Chimica Acta, 41, 1532-1535.
  • Kim J-W, Lee G, Moon S-M, Park M-J, Hong S-K, Ahn Y-H, Kim K-R, and Paik M-J(2010) Metabolomic screening and star pattern recognition by urinary amino acid profile analysis from bladder cancer patients, Metabolomics, 6, 202-206.
  • Paik M-J, Kim H, Lee J, Brand J, and Kim K-R (2009) Separation of triacylglycerols and free fatty acids in microalgal lipids by solid-phase extraction for separate fatty acid profiling analysis by gas chromatography, Journal of Chromatography A, 1216, 5917-5923.
  • Paik M-J, Kuon D, Cho J, and Kim K-R (2009) Altered urinary polyamine patterns of cancer patients under acupuncture therapy, Amino Acids, 37, 407-413.
  • Paik M-J, Li W-Y, Ahn Y-H, Lee P-H, Choi S, Kim K-R, Kim Y-M, Bang O-Y, and Lee G (2009) The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats, Clinica Chimica Acta, 402, 25-30.
  • Yu J, Lee G, Jeong Y, Ahn Y-H, Hu M-B, Kim S-J, Kim K-R, and Paik M-J (2009) Enantiomeric Composition tests of ketoprofen in equine plasma and urine as diastereomeric (S)-(-)-1-phenylethylamides by achiral GC-MS, Chromatographia, 69, 59-63.
  • Paik M-J, Lee J, and Kim K-R (2008) N-Ethoxycarbony-lation combined with (S)-1- phenylethylamidation for enantioseparation of amino acids by achiral gas chromato-graphy and gas chromatography–mass spectrometry, Journal of Chromatography A, 1214, 151–156.

Paik, Soo-Heui

  • Name : Paik, Soo-Heui
  • Major : Clinical Pharmacy
  • Lectures : Pharmacotherapeutics, Pharmacokinetics, Pharmaceutical Administration
  • Tel : 061) 750-3766
  • EMAIL : shwhite@scnu.ac.kr

Academic Backgrounds

  • B.S. : Seoul National University
  • M.S. : Sookmyung Women's University
  • Ph.D. : Sungkyunkwan University

Major Career Achievements

  • Intern pharmacist, Seoul National University Hospital
  • Clinical research pharmacist, Clinical Medicine Laboratory, Seoul National University Hospital
  • Chief pharmacist (injection section), Pediatric Pharmacy, Seoul National University Hospital
  • Medical Dept., Janssen Korea
  • Senior Researcher, Central Research Lab, Boryung Pharmaceutical

Papers

  • Ghim J.-L., Paik S.H., Md. Hasanuzzaman, Chi Y.H., Choi H.G., Kim D.-H. Shin J.-G. 2015. Absolute Bioavailability and Pharmacokinetics of the Angiotensin II Receptor Antagonist Fimasartan in Healthy subjects. J. Clin. Pharmacol. DOI: 10.1002/jcph.618.
  • Kim T.H., Shin S., Landersdorfer C.B., Chi Y.H., Paik S.H., Myung J., Yadav R., Horkovics-Kovats S., Bulitta J.B., Shin B.S. 2015. Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rat, Dog and Human. AAPS Journal 17(5), 1210-1223.
  • Kim T.H., Kim M.K., Kim M.G., Shin B.S., Kim K.-B., Lee J.B., Paik S.H., Yoo S.D. 2015. Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS with polarity switching: application to ADME studies. Talanta 144, 29-38.
  • Lee J.-Y., Choi Y.J., Oh S.J., Chi Y.H., Paik S.H., Lee K.H., Jung J.-K., Ryu C.S., Kim K.-B., Kim D.-H., Yoon Y.-R., Kim S.K. 2015. Characterization of fimasartan metabolites in human liver microsomes and human plasma. Xenobiotica, Published online: 11 Jun 2015. DOI:10.3109/00498254.2015.1047429
  • Jeong E.-S., Kim Y.-W., Kim H.-J., Shin H.-J., Shin J.-G., Kim K.H., Chi Y.H., Paik S.H., Kim D.-H. 2015. Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3. Xenobiotica 45(1), 10-18.
  • Kim, T.H., Shin, S., Bashir, M., Chi, Y.H., Paik, S.H., Lee, J.H., Choi, H.J., Choi, J.H., Yoo, S.D., Bulitta, J.B., 2014. Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats. Xenobiotica , 1-13.
  • Chi, Y.H., Lee, J.H., Kim, J.H., Tan, H.K., Kim, S.L., Lee, J.Y., Rim, H.K., Paik, S.H., Lee, K.T., 2013. Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist. Biol. Pharm. Bull. 36(7), 1208-1215.
  • Choi, M.J., Kwon, G.H., Han, N.S., Yoo, B.W., Kim, J.H., Paik, S.H., Chi, Y.H., Lee, K., Lee, J.Y., 2013. Development of 3D-QSAR CoMSIA models for 5-(biphenyl-2-yl)-1 H-tetrazole derivatives as angiotensin II receptor type 1 (AT 1) antagonists. Bioorg. Med. Chem. Lett. 23, 4540-4546.
  • Ryu S., Shin J.-S., Cho Y.-W., Kim H.K., Paik S.H., Lee J.H., Chi Y.H., Kim J.H., Kim J.H., Lee K.-T. 2013. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase ex-pressions via nuclear factor-kappa b and activator protein-1 inactivation. Biol. Pharm. Bull. 36(3), 467-474.
  • Choi, H., Choi, J., Lee, J.Y., Kim, J.H., Kim, J.H., Lee, J.K., Kim, G.I., Park, Y., Chi, Y.H., Paik, S.H., 2013. Synthesis and evaluation of nicotinamide derivative as anti-angiogenic agents. Bioorg. Med. Chem. Lett. 23, 2083-2088.
  • Kim, J.H., Lee, J.H., Paik, S.H., Kim, J.H., Chi, Y.H., 2012. Fimasartan, a novel angiotensin II receptor antagonist. Arch. Pharm. Res. 35, 1123-1126.
  • Choi, H., Yoo, M., Choi, J., Lee, J.Y., Kim, J.H., Kim, J.H., Lee, J.K., Kim, G.I., Park, Y., Chi, Y.H., Paik S.H., Lee J.H., Lee K.-T., 2011. BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells. Bioorg. Med. Chem. Lett. 21, 6236-6241.
  • Chi, Y.H., Lee, H., Paik, S.H., Lee, J.H., Yoo, B.W., Kim, J.H., Tan, H.K., Kim, S.L., 2011. Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in the fasted and fed states in healthy subjects. American Journal of Cardiovascular Drugs 11, 335-346.
  • Shin, B.S., Kim, T.H., Paik, S.H., Chi, Y.H., Lee, J.H., Tan, H.K., Choi, Y., Kim, M., Yoo, S.D., 2011. Simultaneous determination of fimasartan, a novel antihypertensive agent, and its active metabolite in rat plasma by liquid chromatography-tandem mass spectrometry. Biomedical Chromatography 25, 1208-1214.

Lyu, Su-Yun

  • Name : Lyu, Su-Yun
  • Major : Natural Medicine
  • Lectures : Pharmacognosy
  • Tel : 061) 750-3759
  • EMAIL : suyun@scnu.ac.kr

Academic Backgrounds

  • B.S. : Dongduk Women's University
  • M.S. : Sungkyunkwan University
  • Ph.D. : Univ. of Nottingham

Major Career Achievements

  • Researcher, Chemistry Dept., Seoul Women's University
  • Post-Doc, Tokyo Women's Medical University IREIIMS
  • Deputy Section Chief (Grade 4), Project Planning, Korea Testing and Research Institute
  • Professor (Dean), Korean Medicine Pharmacology, Daegu Haany University

Papers

  • Han, S. Y., Hong, C. E., Kim, H. K., and Lyu, S. Y. Anti-cancer effects of enteric-coated polymers containing mistletoe lectin in murine melanoma cells in vitro and in vivo. Mol. Cell Biochem. 408, 73-87 (2015)
  • Hong, C. E., Park, A. K, and Lyu, S. Y. Synergistic anticancer effects of mistletoe lectin and doxorubicin in breast cancer cells. Mol. Cell Biochem. 394, 225-235 (2014)
  • Hong, C. E. and Lyu, S. Y. Evaluation of the mutagenic properties of two lignans from Acanthopanax koreanum Nakai. Toxicol. Res. 29(4), 279-283 (2013)
  • Oh, J., Hwang, I. H., Hong, C. E., Lyu, S. Y., and Na, M. K. Inhibition of fatty acid synthase by ginkgolic acids from the Leaves of Ginko biloba and their cytotoxic activity. J. Enzym. Inhib. Med. Ch. 28(3), 565-568 (2013)
  • Lyu, S. Y., Choi, J. H., Lee, H. J., Park, W. B., and Kim, G.. J. Korean mistletoe lectin promotes proliferation and invasion of trophoblast through the regulation of the Akt signaling. Reprod. Toxicol. 39, 33-39 (2013)
  • Lyu, S. Y., Shin, A. H., Hahn, D. R., and Park, W. B. Antioxidant activity of cyanidins isolated from Acanthopanax divaricatus var. albeofructus fruits in U937 macrophages. Food Sci. Biotech. 21(5), 1445-1450 (2012)
  • Choi, J. H., Lyu, S. Y., Lee, H. J., Jung, J. E., Park, W. B., and Kim, G. J. Korean mistletoe lectin regulates self-renewel of the placenta-derived mesenchymal stem cells via autophagic mechanisms. Cell Prolif. 45(5), 420-429 (2012)
  • Lyu, S. Y. and Park, W. B. Photoprotective potential of anthocyanins isolated from Acanthopanax divaricatus var. albeofructus fruits against UV irradiation in human dermal fibroblast cells. Biomol. Ther. 20(2), 201-206 (2012)
  • Hong, C. E. and Lyu, S. Y. the anti-mutagenic Effect of Mistletoe Lectin(Viscum album L. var. coloratum agglutinin). Phytother. Res. 26, 787-790 (2011)
  • Lyu, S. Y. and Park, W. B. Gene network analysis on the effect of Viscum album coloratum in T cell sstimulated with anti-CD3/CD28 antibodies. Arch. Pharm. Res. 34(10), 1735-1749 (2011)
  • Hong, C. E., Cho, M. C., Jang, H. A., and Lyu, S. Y. Mutagenicity and Anti- Mutagenicity of Acanthopanax divaricatus var. albeofructus. J. Toxicol. Sci. 36(5), 661-668 (2011)
  • Hong, C. E., Ji, S. T., and Lyu, S. Y. Absence of mutagenic effects of three Nigerian medicinal plants, Bidens pilosa, Cleistopholis paterns, and Tetrapleura tetraptera. Trop. J. Pharm. Res. 10(2), 153-159 (2011)
  • Hong, C. E and Lyu, S. Y. Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes. Immune Network 11(1), 42-49 (2011)
  • Hong, C. E. and Lyu, S. Y. Genotoxicity study on five medicinal plants in Nigeria. J. Toxicol. Sci. 36(1), 87-93 (2011)
  • Lyu, S. Y. and Park, W. B. Effect of Korean mistletoe lectin on gene ex-pression profile in human T lymphocytes: A microarray study. Biomol. Ther. 18(4), 411-419 (2010)
  • Lyu, S. Y. and Park, W. B. Mistletoe Lectin Transport by M cells in Follicle Associated Epithelium (FAE) and IL-12 Secretion in Dendritic cells situated below FAE in vitro. Arch. Pharm. Res. 33(9), 1433-1441 (2010)
  • Lyu, S. Y. and Park, W. B. Modulation of IL-12 and IFN-γ Secretions by Eleutheroside E, Tortoside A, and Syringaresinol from Acanthopanax koreanum Nakai. Biomol. Ther. 18(2), 211-218 (2010)
  • Lyu, S. Y. and Park, W. B. Mistletoe lectin modulates intestinal epithelial cell-derived cytokines and B cell IgA secretion. Arch. Pharm. Res. 32(3), 443-51 (2009)

Mina Lee

  • Name : Mina Lee
  • Major : Natural Product Chemistry
  • Lectures : Natural Pharmaceutical Material, Herbal Medicine
  • Tel : 061) 750-3764
  • EMAIL : minalee@scnu.ac.kr

Academic Backgrounds

  • B.S. : Kyunghee University
  • M.S. : Seoul National University
  • Ph.D. : Seoul National University

Major Career Achievements

  • Post-Doc, Medicine Research Laboratory, Seoul National University
  • Trainee Researcher, College of Pharmacy, Seoul National University

Papers

  • Sung SH, Lee M. Anti-adipogenic activity of a new cyclic diarylheptanoid isolated from Alnus japonica on 3T3-L1 cells via modulation of PPARγ, C/EBPα and SREBP1c signaling. Bioorg Med Chem Lett. 2015, 25(20):4648-51.
  • Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ. Kuwanon v inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. PLoS One. 2015, 10(2):e0118188.
  • Isolation and structure elucidation of (-)-idescarparide, a new spiro compound from Idesia polycarpa. Tetrahedron Letters. 2014 55:5447-5449.
  • Lee M, Kim DH, Choi SZ, Son M, Sung SH. Analysis of Dioscorea japonica by Hydrophilic Interaction Liquid Chromatography. Anal Lett. 2014, 47:901-10
  • Lee M, Kim SH, Lee HK, Cho Y, Kang J, Sung SH. ent-Kaurane and ent-pimarane diterpenes from Siegesbeckia pubescens inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglia. Biol Pharm Bull. 2014, 37(1):152-7
  • Jeong EJ, Hwang L, Lee M, Lee KY, Ahn MJ, Sung SH. Neuroprotective biflavonoids of Chamaecyparis obtusa leaves against glutamate-induced oxidative stress in HT22 hippocampal cells. Food Chem Toxicol. 2014, 64:397-402
  • Cho N, Yang H, Lee M, Huh J, Kim HW, Kim HP, Sung SH. Neuroprotective Benzyl Benzoate Glycosides from Disporum viridescens Roots in HT22 Hippocampal Neuronal Cells. J Nat Prod. 2013, 76(12):2291-7
  • Lee M, Lee SH, Kang J, Yang H, Jeong EJ, Kim HP, Kim YC, Sung SH. Salicortin-derivatives from Salix pseudo-lasiogyne twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C/EBPα and SREBP1c dependent pathway. Molecules, 2013, 18(9):10484-96
  • Lee M, Lee HH, Lee JK, Ye SK, Kim SH, Sung SH. Anti-adipogenic activity of compounds isolated from Idesia polycarpa on 3T3-L1 cells. Bioorg Med Chem Lett, 2013, 23(11):3170-4
  • Lee M, Song JY, Chin YW, Sung SH. Antiadipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells, Bioorg Med Chem Lett, 2013, 23(7):2069-73
  • Lee M, Park JH, Min DS, Yoo H, Park JH, Kim YC, Sung SH. Antifibrotic activity of diarylheptanoids from Betula platyphylla toward HSC-T6 Cells. Biosci Biotechnol Biochem, 2012, 76(9):1616-1620
  • Lee M, Lee MK, Kim YC, Sung SH. Antifibrotic constituents of Alnus firma on hepatic stellate cells, Bioorg Med Chem Lett, 2011, 21(10):2906-2910
  • Sung SH, Park SH, Song SY, Lee SJ, Lee HW, Kim SH, Lee MA, Yoon IS, Kim DD, Kang S, Sung JH. Epidermal regeneration by ent-16α, 17-dihydroxy-kauran-19-oic acid isolated from Siegesbeckia pubescens, Cell Prolif, 2011, 44(6):527-536
  • Lee MA, Lee HK, Kim SH, Kim YC, Sung SH. Chemical constituents of Alnus firma and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia, Planta Med, 2010, 76(10):1007-1010
  • Kim SY, Kim HP, Yang H, Lee M, Ryu HJ, Jang YP, Sung SH, Kim YC. Antifibrotic activity of LCC, a cerebroside of Lycium chinense fruit, in bile duct-ligated rats. Nat Prod Sci 2009,15(2):101-105

Yee, Sung-Tae

  • Name : Yee, Sung-Tae
  • Major : Immunology
  • Lectures : Molecular Cell Biology, Immunology
  • Tel : 061) 750-3752
  • EMAIL : sungtae@scnu.ac.kr

Academic Backgrounds

  • B.S. : Pusan National University
  • M.S. : Pusan National University
  • Ph.D. : Tokyo University

Major Career Achievements

  • Dean of College of Pharmacy, Sunchon National University
  • Dean of Pharmacy Dept., Assistant Dean of College of Pharmacy, Sunchon National University
  • Post-Doc., National Institutes of Health, Japan
  • Researcher, Biotechnology Lab, Korea Institute of Science and Technology
  • Experiment and Training Center, Sunchon National University
  • Participating Professor, BK21 Project Team

Papers

  • The inhibitory effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis International Journal of Endocrinology ID 132436 2015
  • Production of novel vinegar having antioxidant and anti-fatigue activities fromSalicornia herbacea L. Journal of Science Food Agric DOI 10.1002/jsfa. 2015
  • Antiosteoporosis activity of new oriental medicine preparation(Kyungokgo mixed with water extract of Hovenia dulcis) on the ovariectomized mice EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2015
  • Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells through the Induction of Apoptosis and Suppression of Tumorigenic Potentials PLOS ONE 2014
  • 3-deoxysilybin exerts anti-inflammatory effects by suppressing NF-κB activation in lipopolysaccharide-stimulated RAW264.7 macrophages Bioscience Biotechnology and Biochemistry 10.1080/09168451 2014
  • Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway INTERNATIONAL JOURNAL OF ONCOLOGY 45(5) 1969-1976 2014
  • Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014
  • Enhanced dendritic cell maturation by the B-chain of Korean mistletoe lectin (KML-B), a novel TLR4 agonist INTERNATIONAL IMMUNOPHARMACOLOGY 21 309-319 2014
  • Simultaneous analysis of seven 2-hydroxy fatty acids as tert-butyldimethylsilyl derivatives in plasma by gas chromatography-mass spectrometry Biomedical Chromatography DOI 10.1002/bcm.3251 2014
  • Immunoadjuvant efficacy of N-carboxymethyl chitosan for vaccination via dendritic cell activation Journal of Medicinal Food 17(2) 268-277 2014
  • Protective effects of HemoHIM on immune and hematopoietic system against gamma-irradiation Phytotherapy Research 28(2) 245-251 2014
  • Preventative effect of an herbal preparation(HemoHIM) on development of airway inflammation in mice via modulation of Th1/2 cells differentiation PLoS ONE 2013
  • Method optimization for rapid measurement of carbohydrates in plasma by liquid chromatography tandem mass spectrometry Bulletin of the Korean Chemical Society 34(5) 1571-1574 2013
  • Organic acid profiling analysis in culture media of latic acid bacteria by gas chromatography-mass spectrometry Mass Spectrometry 3(3) 74-77 2012
  • Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells EXPERIMENTAL AND THERAPEUTIC MEDICINE 3(4) 592-598 2012
  • Jin Lee, Sung-Tae Yee, Jong-Jin Kim, Myung-Sook Choi, Eun-Young Kwon, Kwon-Il Seo, Mi-Kyung Lee. Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin–nicotinamide-induced diabetic mice. Chemico-Biological Interactions. 188(3), 635-642 (2010).
  • S.J. Cho, J.I. Bang, X.F. Yu, Y.S. Lee, J.H. Kim, J.T. Jeon, c, S.T. Yee, I.K. Kong. Generation of a recloned transgenic cat expressing red fluorescence protein. Theriogenology. 73(7), 848-855 (2010).
  • Hae-Ran Park, Eun-Jin Ju, Sung-Kee Jo, Uhee Jung, Sung-Ho Kim and Sung-Tae Yee. Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer. 9(85), (2009).
  • Jae-Yong Kim, Kyoung-Wuk Park, Kwang-Deog Moon, Mi-Kyung Lee, Jina Choi, Sung-Tae Yee, Ki-Hwan Shim, Kwon-Il Seo. Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. Food and Chemical Toxicology. 46(12), 3753-3758 (2008).
  • Jin GZ, Cho SJ, Choi EG, Lee YS, Yu XF, Choi KS, Yee ST, Jeon JT, Kim MO, Kong IK. Rat mesenchymal stem cells increase tyrosine hydroxylase ex-pression and dopamine content in ventral mesencephalic cells in vitro. Cell Biol Int. 32(11), 1433-8 (2008).
  • S. Y. Ko, I. H. Bae, S. T. Yee, S. S. Lee, D. Uuganbayar, J. I. Oh and C. J. Yang. Comparison of the Effect of Green Tea By-product and Green Tea Probiotics on the Growth Performance, Meat Quality, and Immune Response of Finishing Pigs. Asian-Aust. J. Anim. Sci. 21(10), 1486-1494 (2008).
  • Jang SM, Yee ST, Choi J, Choi MS, Do GM, Jeon SM, Yeo J, Kim MJ, Seo KI, Lee MK. Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. Int Immunopharmacol. 9(1), 113-9 (2009).
  • Jin GZ, Yin XJ, Yu XF, Cho SJ, Choi EG, Lee YS, Jeon JT, Yee ST, Kong IK. neration of neuronal-like cells from umbilical cord blood-derived mesenchymal stem cells of a RFP-transgenic cloned cat. J Vet Med Sci. 70(7), 723-6 (2008).
  • Yu Mi Lee, Eun Jung Lee, Sung Tae Yee, Byung Il Kim, Eun Sang Choe and Hyun Wook Cho. In vivo and in vitro response to electrochemically anodized Ti-6Al-4V alloy. Journal of Materials Science: Materials in Medicine. 19(5), 1851-1859 (2008).
  • Kim SY, Park KW, Kim JY, Shon MY, Yee ST, Kim KH, Rhim JS, Yamada K, Seo KI. Induction of apoptosis by thiosulfinates in primary human prostate cancer cells. Int J Oncol. 32(4), 869-75 (2008).
  • Kim SY, Park KW, Kim JY, Jeong IY, Byun MW, Park JE, Yee ST, Kim KH, Rhim JS, Yamada K, Seo KI. Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells. Bioorg Med Chem Lett. 1;18(1), 199-204 (2008).
  • Toshiki Tamura, Takeshi Kunimatsu, Sung-Tae Yee, Osamu Igarashi, Masanori Utsuyama, Shin Tanaka, Shun-ichi Miyazaki, Katsuiku Hirokawa and Hideo Nariuchi. Molecular mechanism of the impairment in activation signal transduction in CD4+ T cells from old mice. 12(8), 1205-1215 (2000).

Son, Young-Jin

  • Name : Son, Young-Jin
  • Major : Biochemical Engineering
  • Lectures : Physical Pharmacy, Molecular Biology
  • Tel : 061) 750-3755
  • EMAIL : sony@scnu.ac.kr

Academic Backgrounds

  • B.S. : Sungkyunkwan University
  • M.S. : Sungkyunkwan University
  • Ph.D. : Seoul National University

Major Career Achievements

  • Deputy Section Chief, Biological Engineering Lab., CKD Bio
  • Research Professor, College of Medicine, University of Ulsan
  • Post-Doc.m NIH (NIDDK) Biotechnology Lab. , US

Papers

  • Kim KJ, Leutou AS, Yeon JT, Choi SW, Kim SH, Yee ST, Choi KH, Nam SJ, Son YJ. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. Int. J. Endocrinol. 2015: 132436
  • Kim KJ, Yeon JT, Choi SW, Moon SH, Ryu BJ, Yu R, Rark SJ, Kim SH, Son YJ. Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts. Bone 81:208-216. 2015
  • Kim CK, Lee SB, Son YJ. Large-Scale Refolding and Enzyme Reaction of Human Preproinsulin for Production of Human Insulin. J. Microbiol. Biotechnol. 2015
  • Yeon JT, Choi SW, Ryu BJ, Kim KJ, Lee JY, Byun BJ, Son YJ, Kim SH. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. J. Nat. Prod. 78(4):776-82. 2015
  • Park SJ, Lee SH, Kim KJ, Kim SG, Kim H, Choe H, Lee SY, Yun JM, Cho JY, Chun J, Choi KS, Son YJ. Soluble ex-pression and purification of receptor activator of nuclear factor-kappa B ligand using Escherichia coli. J. Microbiol. Biotechnol. 25(2):274-9. 2015
  • Yeon JT, Ryu BJ, Choi SW, Heo JC, Kim KJ, Son YJ, Kim SH. Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways. Amino Acids 46(11):2605-14. 2014
  • Kim H, Kim KJ, Yeon JT, Kim SH, Won DH, Choi H, Nam SJ, Son YJ, Kang H. Placotylene A, an inhibitor of the receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp. Mar. Drugs 12(4):2054-65. 2014
  • Yeon JT, Kim KJ, Choi SW, Moon SH, Park YS, Ryu BJ, Oh J, Kim MS, Erkhembaatar M, Son YJ, Kim SH. Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. PLoS One 9(2):e88974. 2014
  • Druz A, Son YJ, Betenbaugh M, Shiloach J. Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metab. Eng. 16:87-94. 2013
  • Min CK, Lee JW, Kim CK, Kim SH, Lee SY, Lee SM, Son YJ. Insulin related compounds and identification. J. Chromatogr. B 908:105-12. 2012
  • Son YJ, Phue JN, Trinh LB, Lee SJ, Shiloach J. The role of Cra in regulating acetate excretion and osmotic tolerance in E.coli K-12 and E.coli B at high density growth. Microbial Cell Factories. 10(52). 2011.
  • Min CK, Son YJ, Kim CK, Park SJ, Lee JW. Increased ex-pression, folding and enzyme reaction rate of recombinant human insulin by selecting appropriate leader peptide. Journal of Biotechnology. 151(4):350-356. 2011
  • Son YJ, Bae JY, Chong SH, Lee HS, Mo SH, Kim TY, Choe H. High cell density culture and purification of recombinant EC-SOD in Escherichia coli. Applied Biochemistry and Biotechnology. 162(6):1585-1598. 2010
  • Son YJ, Kim CK, Kim YB, Kweon DH, Park YC, Seo JH. Effects of citraconylation on enzymatic modification of human proinsulin using trypsin and carboxypeptidase B. Biotechnology Progress. 25(4):1064-1070. 2009
  • Lee HS, Son YJ, Chong SH, Bae JY, Leem CH, Jang YH, Choe H. Computational analysis of the quaternary structural changes induced by point mutations in human UDP-glucose dehydrogenase. Archives of Biochemistry and Biophysics. 486(1):35-43. 2009
  • Son YJ, Kim CK, Choi BT, Park YC, Seo JH. Effects of β-mercaptoethanol and hydrogen peroxide on enzymatic conversion of human proinsulin to insulin. Journal of Microbiology and Biotechnology. 18(5):983-989. 2008
  • Son YJ, Rha CS, Park YC, Shin SY, Lee YS, Seo JH. Production of cyclodextrins in ultrafiltration membrane reactor containing cyclodextrin glycosyl- transferase from Bacillus macerans. Journal of Microbiology and Biotechnology. 18(4):725-729. 2008
  • Son YJ, Park KH, Lee SY, Oh SJ, Kim CK, Choi BT, Park YC, Seo JH. Effects of temperature shift strategies on human preproinsulin production in the fed-batch fermentation of recombinant Escherichia coli. Biotechnology and Bioprocess Engineering. 12(5):556-561. 2007

Dongjo Chang

  • Name : Dongjo Chang
  • Major : Pharmaceutical Chemistry
  • Lectures : Pharmaceutical Chemistry, Radiopharmaceuticals
  • Tel : 061) 750-3765
  • EMAIL : djchang@scnu.ac.kr

Academic Backgrounds

  • B.S. : Dongguk University
  • M.S. : Dongguk University
  • Ph.D. : Seoul National University

Major Career Achievements

  • Senior Researcher, New Medicine R&D Lab, C-Tri
  • Senior Researcher, Medicine Research Laboratory, Seoul National University
  • Post-Doc.m NIH (NIDDK) Biotechnology Lab. , US

Papers

  • Kim, K.; Kim, S. J.; Han, Y. T.; Hong, S. J.; An, H.; Chang, D. J.; Ki, T.; Lim, B.; Lee, J.; Surh, Y. J.; Suh, Y. G. Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action. Bioorg. Med. Chem. Lett. 2015, In Press.
  • Lee, S.; An, H.; Chang, D. J.; Jang, J.; Kim, K.; Shim, J.; Lee, J.; Suh, Y. G. Total Synthesis of (-)-deguelin via iterative pyran-ring formation. Chem. Comm. 2015, 51, 9026.
  • Jo, D. H.; An, H.; Chang, D. J.; Baek, Y. Y.; Cho, C. S.; Jun, H. O.; Park, S. J.; Kim, J. H.; Lee, H. Y.; Kim, K. W.; Lee, J.; Park, H. J.; Kim, Y. M.; Suh, Y. G.; Kim, J. H. Hypoxia-Mediated Retinal Neovascularization and Vascular Leakage in Diabetic Retina is Suppressed by HIF-1α Destabilization by SH-1242 and SH-1280, Novel Hsp90 Inhibitor. J. Mol. Med. 2014, 92, 1083.
  • Chang, D. J.; Kim, W. J. Discovery of structurally simplified analogs of colchicine as an immunosuppressant. Bioorg. Med. Chem. Lett. 2014, 24, 3121.
  • Chang, D. J.; An, H.; Kim, K. S.; Park, J. W.; Kim, N. J.; Han, Y. T.; Yun, H.; Lee, S.; Lee, G.; Lee, S.; Cha, J. H.; Park, J. H.; Lee, S. C.; Kim, J. H.; Lee, H. Y; Kim, K. W.; Suh, Y. G. Design, Synthesis and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein (HSP) 90 Inhibitors Targeting Proliferation and Angiogenesis. J. Med. Chem. 2012, 55, 10863.
  • Chang, D. J.;Lee, S.; Jang, J.; Kim, S. O.; Kim, W. J.; Suh, Y. G. Part II. Development of Novel Colchicine-Derived Immunosuppressant with Improved Pharmacokinetic Properties.Bioorg. Med. Chem.Lett. 2012, 22, 6750.
  • Han, Y. T.; Choi, G. I.; Son, D.; Kim, N. J.; Yun, H.; Lee, S.; Chang, D. J.; Hong, H. S.; Kim, H.; Ha, H. J.; Kim, Y. H.; Park, H. J.; Lee, J.; Suh, Y. G. Ligand-Based Design, Synthesis, and Biological Evaluation of 2-Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors. J. Med. Chem. 2012, 55. 9120
  • Jang, J.; Jung, J. W.; Ahn, J; Shim, J,; Chang, D. J.; Kim, D. D.; Suh, Y. G. Asymmetric Formal Synthesis of Schulzeines A and C. Org. Biomol. Chem. 2012, 10, 5202.Yun, H.; Kim, J.; Shim, J.; Lee, S.; Han, Y. T.; Chang, D. J.; Kim, D. D.; Suh, Y. G. Asymmetric Syntheses of 1-Deoxy-6,8a-di-epi-castanospermine and 1-Deoxy-6-epi-castanospermine. J. Org. Chem. 2012, 77, 5389-5393.
  • Chang, D. J.; Jeong, M.Y.; Song, J.; Chang, Y. J.; Suh, Y. G.; Kim, H. J.; Min, K. H. Discovery of Small Molecules that Enhance Astrocyte Differentiation in Rat Fetal Neural Stem Cells. Bioorg. Med. Chem. Lett. 2011, 21, 7050.
  • Kim, N. J.; Moon, H.; Park, T.; Yun, H.; Jung, J. H.; Chang, D. J.; Kim, D. D.; Suh, Y. G. Concise and Enantioselective Total Synthesis of 15-Deoxy-Δ12,14-Prostaglandin J2. J. Org. Chem., 2010,75, 7458.
  • Lee, Y. S.; Jung, J. H.; Kim, S. H.; Jung, J. K.; Paek, S. M.; Kim, N. J; Chang, D. J.; Suh, Y. G. First Total Synthesis and Structural Confirmation of Fluvirucinine A2 via an Iterative Ring Expansion Strategy. Org. Lett. 2010, 12, 2040.
  • Paek, S. M.;Kim, N. J.; Shin, D.; Jung, J. K.; Jung, J. H.; Chang, D. J.; Suh, Y. G.A Concise Total Synthesis of (+)-Tetrabenazine and (+)-α-Dihydrotetrabenazine. Chem- Eur. J. 2010, 16, 4623.
  • Chang, D. J.; Yoon, E. Y.; Lee, G. B.; Kim, S. O.; Kim, W. J.; Kim, Y. M.; Jung, J. W.; An, H.; Suh, Y. G. Design, Synthesis and Identification of Novel Colchicine-Derived Immunosuppressant. Bioorg. Med. Chem. Lett. 2009, 19, 4416.
  • Li, F.; Kim, N. J.; Chang, D. J.; Jang, J.; Jang, H.; Jung, J. W.; Min, K. H.; Jeong, Y. S.; Kim, S. Y.; Park, Y. H.; Kim, H. D.; Park, H. G.; Suh, Y. G. Synthesis and Structural Optimization of Multiple H-Bonding Region of Diarylalkyl (thio)amides as Novel TRPV1 Antagonists. Bioorgan. Med. Chem. 2009, 17, 8149.
  • Paek, S. M.; Yun, H.; Kim, N. J.; Jung, J. H.; Chang, D. J.; Lee, S. J.; Yoo, J.; Park, H. J.; Suh, Y. G. Concise Syntheses of (+)-Macrosphelides A and B: Studies on the Macro-Ring Closure Strategy. J. Org. Chem. 2009, 74, 554.
  • Chang, D. J.; Kim, W. Y.; Hennessy, B.; Kang, H. J.; Yoo, J.; Han, S. H.; Kim, Y. S.; Park, H. J.; Seo, S. Y.; Mills, G.; Kim, K. W.; Hong, W. K.; Suh, Y. G.; Lee, H. Y. A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy. Cancer Prev. Res. 2008, 1, 577.
  • Suh, Y. G.; Kim, N. J.; Koo, B. W.; Lee, K. O.; Moon, S. H.; Shin, D. H.; Jung, J. H.; Paek, S. M.; Chang, D. J.; Li, F. Design, Synthesis, and Biological Evaluation of Novel Constrained meta-Substituted Phenyl Propanoic Acids as Peroxisome Proliferator-Activated Receptor α and γ Dual Agonists. J. Med. Chem. 2008, 51, 6318.

Kyung Hee Choi

  • Name : Kyung Hee Choi
  • Major : Clinical Pharmacy
  • Lectures : Pharmacotherapy, Prescription Pharmacy and Patients education, Pharmacy Practice
  • Tel : 061) 750-3763
  • EMAIL : khchoi@scnu.ac.kr

Academic Backgrounds

  • B.S. : Seoul National University
  • M.S. : Seoul National University

Major Career Achievements

  • Intern Pharmacist, Seoul National University Hospital
  • Resident Pharmacist, Seoul National University Hospital
  • Pharmacist, Clinical Pharmacy, Seoul National University Hospital
  • Preceptor, 6-year Preliminary Training Program, Seoul National University Hospital

Papers

  • Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting J Korean Med Sci.2010 Mar;25(3):337-41
  • Benefit of Pharmacists’ intervention on self medications and discharge orders in the cardiology ward, Journal of the Korean Society of Health-System Pharmacists (KSHP), 2009; Vol.25 No. 04
  • Dosage Adjustment before and after Warfarin - Rifampin Combination Therapy Korean J Thorac Cardiovasc Surg 2008 Jun; 41(03) 354-359
  • Evaluation of Warfarin Initiation Regimens in Korean with Deep Vein Thrombosis, Journal of the Korean Society of Health-System Pharmacists, 2005; Vol.21 No. 02
  • The Analysis of Factor on TPN-related Hyperbilirubinemia (2005)

HA, Hyung-Ho

  • Name : HA, Hyung-Ho
  • Major : Pharmaceutical Chemistry (Dean)
  • Lectures : Organic Chemistry, Pharmaceutical Synthetic Chemistry
  • Tel : 061) 750-3700(3754)
  • EMAIL : hhha@scnu.ac.kr

Academic Backgrounds

  • B.S. : Chemistry, College of Natural Science, Chonbuk National University
  • M.S. : Organic Synthesis, College of Natural Science, Chonbuk National University
  • Ph.D. : Pharmaceutical Chemistry, Chemistry Dept., College of Natural Science, Seoul National University

Major Career Achievements

  • Dean of College of Pharmacy, Sunchon National University
  • Director of Suncheon Natural Pharmaceutical Material R&D Center
  • Assistant Professor of Pharmacy Dept., College of Pharmacy, Sunchon National University
  • Dean of Pharmacy Dept. Sunchon National University
  • Executive Secretary, Suncheon Natural Pharmaceutical Material R&D Center
  • Director of Bio-pharmacy Research Lab, Sunchon National University
  • Assistant Professor of Pharmacy Dept., College of Pharmacy, Sunchon National University
  • Senior Researcher of Medicine Development, Life Science Research Laboratory, Singapore
  • Post-Doc, Chemistry Dept., Singapore (2009)
  • Leader of New Medicine Development Team, Central Research Laboratory, JW Pharmaceutical
  • Researcher of Chemical Genomics PNRI Research Lab, Seattle (2004)
  • Researcher of Molecular Medicine Lab, Roche Japan
  • Researcher of Central Research Laboratory, JW Pharmaceutical

Papers

  • ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes, Haaglim Cho et al. Scientific Reports, 2017, 7:44186
  • Development of background-free tame fluorescent probes for intracellular live cell imaging, Samira Husen Alamudi et al. NATURE COMMUNICATIONS, 2016
  • Inhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility, Yi Yang et al. PLOS one, 2016, 11(1):e0146575
  • Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility, Yi Yang et al , PLOS one, 2015
  • Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient, Satoshi Arai et al , Chem. Commun. 2015, 51, 8044-8047.
  • Diversity-Oriented Approach for Chemical Biology, Jun-Seok Lee et al, The Chemical Record. 2015, 15, 495-510
  • Chemical Targeting of GAPDH Moonlighting Function in Cancer Cells Reveals Its Role in Tubulin Regulation, Da-Woon Jung et al , Chemistry &Biology. 2014, 21, 1533-1545,
  • Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development, Yun, S. W. et al , Acc. Chem. Res. 2014, 47, 1277-1286.
  • Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene ex-pression analyses, Park, S. J. et al , Stem Cell Res. 2014, 12, 730-741.
  • A fluorescent probe for imaging symmetric and asymmetric cell division in neurospher formation, Yun, S. W. et al , Chem. Commun. 2014, 50, 7492-7494.
  • Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking, Haque, M. M. et al , Amyloid 2014, 21, 185-190.
  • Visualization and isolation of Langerhans islets by fluorescent probe PiY, Kang, N. Y. et al , Angew. Chem., Int. Ed. Engl. 2013, 52, 8557-8560
  • A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes, Jung, D. W. et al , ACS Chem. Biol. 2013, 8, 1271-1282.
  • Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production, Kim, J. Y. et al , ACS Comb. Sci. 2012, 14, 395-398.
  • A fluorescent screening platform for the rapid evaluation of chemicals in cellular reprogramming, Vendrell, M. et al , Stem Cell Res. 2012, 9, 185-191.
  • Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe, Ghosh, K. K.; Hyung-Ho Ha.; Kang, N. Y.; Chandran, Y.; Chang, Y. T. Chem. Commun. 2011, 47, 7488-7490.
  • Embryonic and induced pluripotent stem cell staining and sorting using live cell fluorescence imaging probe CDy1, Kang, N. Y.; Yun, S. W.; Hyung-Ho Ha.; Park, S. J.; Chang, Y. T. Nat. Protoc. 2011, 6, 1044-1052.
  • Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach, Kang, N. Y.; Hyung-Ho Ha.; Yun, S. W.; Yu, Y. H.; Chang, Y. T. Chem. Soc. Rev. 2011, 40, 3613-3626.
  • Fluorescent labeling of membrane proteins on the surface of living cells by a self-catalytic glutathione S-transferase omega 1 tag, Lee, J. J.; Son, J.; Hyung-Ho Ha.; Chang, Y. T. Mol. Biosyst. 2011, 7, 1270-1276.
  • The binding of fluorophores to proteins depends on the cellular environment, Kim, Y. K.; Lee, J. S.; Bi, X.; Hyung-Ho Ha; Ng, S. H.; Ahn, Y. H.; Lee, J. J.; Wagner, B. K.; Clemons, P. A.; Chang, Y. T. Angew. Chem., Int. Ed. Engl. 2011, 50, 2761-2763.
  • Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects, Jung, D. W.; Hyung-Ho Ha.; Zheng, X.; Chang, Y. T.; Williams, D. R. Mol. Biosyst. 2011, 7, 346-358.
  • A fluorescent rosamine compound selectively stains pluripotent stem cells, Im, C. N.; Kang, N. Y.; Hyung-Ho Ha.; Bi, X.; Lee, J. J.; Park, S. J.; Lee, S. Y.; Vendrell, M.; Kim, Y. K.; Lee, J. S.; Li, J.; Ahn, Y. H.; Feng, B.; Ng, H. H.; Yun, S. W.; Chang, Y. T. Angew. Chem., Int. Ed. Engl., 2010, 49, 7497-7500. (pdf) (SI) Highlighted at "Fluorescence method detects stem cells, C&En News 2010, 88(38), p25"
  • Control of Muscle Differentiation by a Mitochondria-Targeted Fluorophore. Yun Kyung Kim, Hyung-Ho Ha, Jun-Seok Lee, Xuezhi Bi, Young-Hoon Ahn, Siti Hajar, Jae-Jung Lee and Young-Tae Chang. J. Am. Chem. Soc. 2010, 132, 576.
  • Discovery of Novel Zebrafish Neural Tracers by Organism-based Screening of Rosamine Library. Jun Li, Hyung-Ho Ha, Lin Guo, David Coomber, and Young-Tae Chang. Chem. Commun. 2010, 46, 2932-2934.
  • Novel Heterocycle-substituted Pyrimidines as Inhibitors of NF-kB Transcription Regulation Related to TNF-a Cytokine Release. Hyung-Ho Ha, Jee Seon Kim and B. Moon Kim, Bioorg. Med. Chem. Lett. 2008, 18.653
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